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Total 20 results found since Jan 2013.

Why Allergy Seasons Are Getting Worse
If you’ve been itchy, congested, and sneezy for months, you’re not alone. This year’s spring allergy season started early, broke pollen-count records in some parts of the country, and is still going strong in many areas. Unfortunately, this year is unlikely to be a fluke. While pollen counts vary from year to year, recent trends suggest allergy seasons are, in general, getting longer and worse, says Dr. Kristine Vanijcharoenkarn, an assistant professor at Emory University School of Medicine who specializes in allergies and immunology. Patients started filling her office early this year, around the beginni...
Source: TIME: Health - May 9, 2023 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Environment healthscienceclimate Source Type: news

Is it time to set the alarmins as potential targets in food allergy?
Food allergies affect an estimated 8% of children, and up to 10% of adults in the United States, and prevalence is increasing over time. 1,2 While primary prevention through early exposure is of utmost importance, there is a substantial need for disease-modifying therapies. Food allergy treatment is an active area of research, particularly in the last several years, leading to the FDA-approval of the first product for this purpose, Palforzia (Aimmune Therapeutics, Brisbane, CA), for peanut oral immunotherapy (OIT) in 2020.
Source: Annals of Allergy, Asthma and Immunology - March 9, 2023 Category: Allergy & Immunology Authors: Amber N. Pepper, Thomas B. Casale Source Type: research

The Economic Burden of Food Allergy: What We Know and What We Need to Learn
AbstractPurpose of ReviewFood allergy management and treatment require dietary modification, are associated with significant burdens, and affect food choices and behaviours. Emerging therapies, such as oral immunotherapy (OIT), provide a glimmer of hope for those living with the condition. Some burdens have received substantial focus, whereas many knowledge gaps on the significance of other impacts, including economic burden, remain.Recent FindingsEvidence from many countries, but disproportionately from the United States, supports that food allergy carries significant healthcare and societal costs. Early introduction for ...
Source: Current Treatment Options in Allergy - April 28, 2022 Category: Allergy & Immunology Source Type: research

Health Disparities in Pediatric Food Allergy
CONCLUSION: Racial, ethnic, and socioeconomic disparities in food allergy among children in the United States are evident and negatively affect the outcomes of children with food allergies. Active efforts to decrease racial and socioeconomic disparities through education, research, and advocacy will be important to help improve health outcomes in food allergy for all children, regardless of their race, ethnicity, or socioeconomic status.PMID:35476967 | DOI:10.1016/j.anai.2022.04.022
Source: Annals of Allergy, Asthma and Immunology - April 27, 2022 Category: Allergy & Immunology Authors: Elizabeth Tepler Katelyn H Wong Gary K Soffer Source Type: research

To mix or not to mix in allergy immunotherapy vaccines
Purpose of review European and US allergists generally do not agree on the approach to subcutaneous allergy immunotherapy in patients with multiple allergies. The North American approach is to treat with a mixture that contains all the allergen extracts to which the patient has evident clinical sensitivity, whereas the European approach is to select for treatment the one or at the most two allergens that are clinically most important for the patient. Recent findings Recent society guidelines continue to recommend these differing practices of treating the polyallergic patient and reviews of prescribing practices ...
Source: Current Opinion in Allergy and Clinical Immunology - November 8, 2021 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Mountain Cedar Allergy: A Review of Current Available Literature
CONCLUSION: Mountain cedar remains a major cause of allergic rhinoconjunctivitis in the south central United States during the winter months. Key treatment strategies involve a combination of allergen avoidance, pharmacologic therapy, and subcutaneous immunotherapy. Allergists can help affected patients in their management of "cedar fever".PMID:34582944 | DOI:10.1016/j.anai.2021.09.019
Source: Annals of Allergy, Asthma and Immunology - September 28, 2021 Category: Allergy & Immunology Authors: Jun Mendoza James Quinn Source Type: research

Evolution of Immune Responses in Food Immunotherapy
Food allergies are a growing public health concern affecting approximately 8% of children and 10% of adults in the United States. Several immunotherapy approaches are under active investigation, including oral immunotherapy, epicutaneous immunotherapy, and sublingual immunotherapy. Each of these approaches uses a similar strategy of administering small, increasing amounts of allergen to the allergic subject. Immunologic studies have described changes in the T-cell compartment, serum and salivary immunoglobulin profile, and mast cell and basophil degranulation status in response to allergens. This review highlights the immu...
Source: Immunology and Allergy Clinics of North America - November 5, 2019 Category: Allergy & Immunology Authors: Johanna M. Smeekens, Michael D. Kulis Source Type: research

Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE
Peanut allergy is one of the most common and severe food allergies, affecting about 2% of school-aged children in the United Kingdom and United States. Current management of peanut allergy consists of strict allergen avoidance and carrying emergency medication to treat acute allergic reactions that can develop after accidental exposure.
Source: Journal of Allergy and Clinical Immunology - October 28, 2019 Category: Allergy & Immunology Authors: Alexandra F. Santos, Louisa K. James, Matthew Kwok, Richard T. McKendry, Katherine Anagnostou, Andrew T. Clark, Gideon Lack Tags: Letter to the editor Source Type: research

Why Parents Are Turning to a Controversial Treatment for Food Allergies
This article was originally published on Undark. Read the original article.
Source: TIME: Health - August 15, 2019 Category: Consumer Health News Authors: Esther Landhuis / Undark Tags: Uncategorized allergies health onetime syndication Source Type: news

Coadministration of Sublingual Immunotherapy Tablets and Management of Potential Adverse Effects: Austrian, German, and Swiss Expert Recommendations.
Abstract Sublingual immunotherapy (SLIT) is currently available as liquid drops and tablets for treatment of allergic patients. Because several allergens are available and many patients are polyallergic, it is possible to treat patients with multiple clinically relevant allergies by >1 SLIT product. Austrian, German, and Swiss medical experts discussed the available data on allergen uptake at the oral mucosa and recently published data on coadministration of a grass and a ragweed tablet. The experts agreed on a schedule considering data from a North American trial on sequential administration of 2 SLIT-tablets ...
Source: Clinical Therapeutics - July 24, 2019 Category: Drugs & Pharmacology Authors: Sturm GJ, Vogelberg C, Marchon M, Horn A, Vitzthum HG, Memar-Baschi MP, Kleine-Tebbe J Tags: Clin Ther Source Type: research

Human Gut-Associated Natural Killer Cells in Health and Disease
Alessandro Poggi1*, Roberto Benelli2, Roberta Venè1, Delfina Costa1, Nicoletta Ferrari1, Francesca Tosetti1 and Maria Raffaella Zocchi3 1Molecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 2Immunology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy 3Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy It is well established that natural killer (NK) cells are involved in both innate and adaptive immunity. Indeed, they can recognize molecules induced at the cell surface by stress signals...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4* 1Department of Biomedical Informatics, Columbia University, New York, NY, United States 2Department of Systems Biology, Columbia University, New York, NY, United States 3Department of Medicine, Columbia University, New York, NY, United States 4Data Science Institute, Columbia University, New York, NY, United States The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research