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Specialty: Neurology
Condition: Overdose

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Total 16 results found since Jan 2013.

Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes
Conclusions: Our findings provide support for the practice of accurately weighing all acute ischemic stroke patients before thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2013 Category: Neurology Authors: Demetrios J. Sahlas, Linda Gould, Richard H. Swartz, Naufal Mohammed, Rhonda McNicoll-Whiteman, Fahd Naufal, Wieslaw Oczkowski Tags: Original Articles Source Type: research

Response to “Effect of Tissue Plasminogen Activator Dose and Interval on Stroke Severity”
We read with interest the comments on our recent study “Tissue Plasminogen Activator Overdose in Acute Ischemic Stroke Patients Linked to Poorer Functional Outcomes” by Nedelman and Glenn, and would like to address the points that were raised.
Source: Journal of Stroke and Cerebrovascular Diseases - December 2, 2013 Category: Neurology Authors: Demetrios J. Sahlas, Linda Gould, Richard Swartz, Naufal Mohammed, Rhonda McNicoll-Whiteman, Fahd Naufal, Wieslaw Oczkowski Tags: Letters to the Editor Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

Renal Function Estimates and Dosing of Direct Oral Anticoagulants in Stroke Patients with Atrial Fibrillation: An Observational Study.
CONCLUSION: Although substituting eGFR for CrCl carries potential risks of DOAC overdosing in patients with AF, the effect might be offset by clinicians' predilection for lower dosage in this stroke cohort. PMID: 31304571 [PubMed - in process]
Source: Acta Neurologica Taiwanica - July 17, 2019 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Ischemic stroke and dose adjustment of oral Factor Xa inhibitors in patients with atrial fibrillation
ConclusionOne in three patients with ischemic stroke during treatment with oral Xa inhibitors used inappropriate dose regimens. Underdosing was associated with lower functional plasma levels, higher clinical stroke severity and worse functional outcome.
Source: Journal of Neurology - March 22, 2020 Category: Neurology Source Type: research

New frontiers in anticoagulation: non vitamin-K oral anticoagulants in stroke prevention.
Authors: Arnao V, Riolo M, Tuttolomondo A, Pinto A, Fierro B, Aridon P Abstract INTRODUCTION: Non vitamin-K oral anticoagulants (NOACs) are direct and specific inhibitors of the coagulation factors IIa (dabigatran) and Xa (apixaban, rivaroxaban, edoxaban) which share many pharmacokinetic properties. However, indications are lacking regarding the use of NOACs during thrombolysis, surgery and bleeding events. Areas covered: In this paper, the authors retrospectively analyzed the relevant literature on the NOACs using the PubMed and Google Scholar databases. Expert Commentary: Although warfarin is effective in cardioembo...
Source: Expert Review of Neurotherapeutics - December 3, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Stroke due to Left Atrial Appendage Thrombus after Pulmonary Vein Isolation despite Novel Oral Anticoagulant: A Case Report
We report on a patient with atrial fibrillation undergoing catheter ablation and cardioversion suffering from ischemic stroke despite being under oral anticoagulation. It turned out that the drug activity of the NOACs used was repeatedly insufficient in spite of regular intake and adequate dosing. In sum, drug activity controls should be taken into consideration in patients with thrombotic events despite oral anticoagulation with NOACs.Case Rep Neurol 2021;13:225 –232
Source: Case Reports in Neurology - April 12, 2021 Category: Neurology Source Type: research

The Impact of Discrepancy between Measured versus Stated Weight on Hemorrhagic Transformation and Clinical Outcomes after Intravenous Alteplase Thrombolysis
Conclusion: More alteplase usage than actual weight led to higher hemorrhagic transformation. As one of the predictors for clinical deterioration, it is important to administrate alteplase based on an accurately measured weight.Cerebrovasc Dis 2017;44:241-247
Source: Cerebrovascular Diseases - August 25, 2017 Category: Neurology Source Type: research

The Effect of Mitochondrial Calcium Uniporter Opener Spermine on Diazoxide against Focal Cerebral Ischemia—Reperfusion Injury in Rats
Conclusions: Our results suggested that diazoxide, which improved neurological deficits and decreased infarct volume and oxidative stress against ischemia–reperfusion injury, is mediated by spermine.
Source: Journal of Stroke and Cerebrovascular Diseases - March 28, 2013 Category: Neurology Authors: Huanli Dong, Shilei Wang, Zongwang Zhang, Ailan Yu, Zhong Liu Tags: Original Articles Source Type: research

Akinetic Mutism And Parkinsonian Features Progressing To Coma Following A Hypoxic Event With Extended Lucid Interval: Manifestations Of Delayed Post-Hypoxic Leukoencephalopathy (P4.033)
CONCLUSIONS: Clinical anticipation and recognition of DPHL should lead to earlier diagnosis and higher-value care.Disclosure: Dr. Doerner Rinaldi has nothing to disclose. Dr. Miller has nothing to disclose. Dr. Czeisler has nothing to disclose. Dr. Willey has nothing to disclose. Dr. John has nothing to disclose. Dr. Claassen has nothing to disclose. Dr. Mayer has received personal compensation for activities with Actelion, Baxter, Biogen Idec, Codman/Johnson & Johnson Company, CSL Behring, Cornerstone Therapeutics, CR Bard, Novartis, Orsan Technologies, Pfizer Inc, Sage Therapeutics, and Stryker. Dr. Mayer has receive...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Doerner Rinaldi, A. P., Miller, E., Czeisler, B., Willey, J., John, C., Claassen, J., Mayer, S., Agarwal, S. Tags: General Neurology III Source Type: research

Re-evaluating Brain Death: The Potential for Treatment and Recovery after Brain Injury (P4.285)
Conclusions: Treatment-induced reversal of BD was evidenced by functional recovery across several domains. ACP neuromodulation optimizes cerebral functioning: electrical stimulation increases metabolic coupling; nutraceuticals promote healing, repair and neurotransmitter production while attenuating inflammatory cascades and free-radical damage. BD may not be definitively irreversible and deserves therapeutic consideration.Disclosure: Dr. Defina has nothing to disclose. Dr. Zakrzewski has nothing to disclose. Dr. Prestigiacomo has nothing to disclose. Dr. Machado has nothing to disclose. Dr. Bernad has nothing to disclose....
Source: Neurology - April 9, 2014 Category: Neurology Authors: Defina, P., Zakrzewski, C., Prestigiacomo, C., Machado, C., Bernad, P., Halper, J., Fellus, J. Tags: Practice, Policy, and Ethics: Stroke, Critical Care, and Other Source Type: research

Mitochondrial Calcium Uniporter Opener Spermine Attenuates the Cerebral Protection of Diazoxide through Apoptosis in Rats
Conclusions: Results in our study suggested that diazoxide improved neurologic deficits, decreased infarct volume in cortex but not in subcortex, and apoptosis in cortex against ischemia/reperfusion injury is mediated by spermine.
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Lei Zhang, Xiujuan Gao, Xin Yuan, Huanli Dong, Zongwang Zhang, Shilei Wang Tags: Original Articles Source Type: research

Predictors of Poor Outcome in Neuroleptic Malignant Syndrome: Retrospective Analysis of Nationwide Inpatient Sample (S32.006)
CONCLUSIONS: In patients admitted for neuroleptic malignant syndrome, every decade increment in age, acute kidney injury, seizures and respiratory failure were positive predictors of poor outcome. Every calendar year increase was a negative predictor of poor outcome. Study Supported by:Disclosure: Dr. Modi has nothing to disclose. Dr. Dharaiya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Modi, S., Dharaiya, D. Tags: Movement Disorders: Tremor, Ataxia, and More Platform Blitz Source Type: research

Neuro-Psychiatry Diseases Predisposing to Mental Status Changes in Patients with Community-Acquired Pneumonia (P1.313)
Conclusions: This study indicates that MSC is frequent in patients with CAP presenting to hospital emergency departments. The etiology of MSC is diverse, with approximately half of the cases due to neuro-psychiatric conditions. In patients presenting to the emergency department with MSC, a high index of suspicion should be maintained regarding the diagnosis of pneumonia.Disclosure: Dr. Kolikonda has nothing to disclose. Dr. Wiemken has nothing to disclose. Dr. Arnold has nothing to disclose. Dr. Nakamatsu has nothing to disclose. Dr. Raghuram has nothing to disclose. Dr. Ramirez has nothing to disclose. Dr. Peyrani has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kolikonda, M., Wiemken, T., Arnold, F., Nakamatsu, R., Raghuram, A., Ramirez, J., Peyrani, P. Tags: Other Bacterial Infections Source Type: research

Ischaemic Stroke Following Ergotamine Overdose
The use of ergotamine in the treatment of migraine has become disputed due to its significant side effects, such as arterial vasospasm particularly affecting peripheral arteries[1]. However, there is conflicting evidence about the effect of ergotamine on cerebral blood flow[2 –4]. Currently, ergotamine continues to be utilised, albeit off-licence, for the treatment of refractory migraine in paediatric patients[5]. Yet, there is a lack of evidence supporting ergotamine’s utility and safety in migraine treatment[5].
Source: Pediatric Neurology - August 5, 2019 Category: Neurology Authors: Nadja F. Bednarczuk, Ming Lim, Ata Siddiqui, Karine Lascelles Tags: Clinical Letter Source Type: research