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Science ’s 2022 Breakthrough of the Year: A telescope’s golden eye sees the universe anew
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Source: ScienceNOW - December 15, 2022 Category: Science Source Type: news

Maternal diet during pregnancy with allergic and respiratory profiles in children
Conclusion: In a large nationwide cohort, maternal diet quality during pregnancy was weakly related to allergic and respiratory multimorbidity profiles up to 5.5 years. These preliminary results should be further explored by studying more specific food groups or scores.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Delvert, R., Charles, M., Dumas, O., Leynaert, B., Nadif, R., Plancoulaine, S., Raherison, C., Sedki, M., Varraso, R., De Lauzon-Guillain, B., Bedard, A. Tags: 07.06 - Paediatric respiratory epidemiology Source Type: research

Foetal exposure to heavy metals and risk of asthma and allergic diseases in early childhood: a population-based birth-cohort study
Conclusions: Our results suggest that prenatal exposure to heavy metals may affect the development of asthma and allergic diseases in childhood.
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Pesce, G., Baiz, N., Huel, G., Annesi Maesano, I., On behalf of the EDEN consortium Tags: Occupational and environmental health Source Type: research

Penicillin Skin Testing, Challenge, and Desensitization in Pregnancy: A Systematic Review.
CONCLUSION: This review demonstrates that the known prevalence of true penicillin allergy extends to pregnant women. PST and desensitization can be safely applied during pregnancy and are tools that should be used more frequently. Further data on the safety of challenge during pregnancy are recommended. PMID: 32005632 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - February 2, 2020 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

The Human Upper Respiratory Tract Epithelium Is Susceptible to Flaviviruses
In this study, we exposed apically well-differentiated human NECs cultured at the ALI to the related flaviviruses ZIKV, JEV, WNV, and Usutu virus (USUV). We selected these viruses due to the recent increasing evidences of potential threat to humans (Cadar et al., 2017; Simonin et al., 2018). We show that NECs are particularly susceptible to JEV and WNV infection and to other flaviviruses included in this study. Infection with each virus led to shedding of infectious virus particles through the apical and basolateral surfaces and triggered host mechanisms at the level of inflammatory and antiviral mediators....
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research

ALCAM Mediates DC Migration Through Afferent Lymphatics and Promotes Allospecific Immune Reactions
In conclusion, our findings identify ALCAM as a novel therapeutic target for preventing corneal allograft rejection in high-risk patient populations. Moreover, given the documented contribution of ALCAM to (lymph)angiogenesis, DC migration, and T cell activation, ALCAM blockade might represent a therapeutic strategy for treating other immune-mediated inflammatory conditions, such as solid organ transplant rejection, allergy or autoimmune diseases. Experimental Procedures Cloning, Expression, and Purification of I/F8-Fc and KSF-Fc For cloning of I/F8-Fc and KSF-Fc the respective scFv sequence was amplified from previousl...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Phenotype-endotype in very severe preschool wheezers:The PtitAsthme cohort
Conclusion: Very severe preschool wheezing pneno-endotype is heterogeneous and can be attributed to 3 classes.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Fayon, M., Siao, V., Blanchon, S., Begueret, H., Benard, A., Berger, P. Tags: Paediatric asthma and allergy Source Type: research

Risk of postpartum depression among women with asthma
ConclusionOur findings suggest that women with asthma are more likely to suffer from postpartum depression. A close monitoring of signs of depression for pregnant women with asthma is indicated, allowing prompt and efficient interventions if needed.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 6, 2018 Category: Allergy & Immunology Source Type: research

In Utero Exposure to Select Phenols and Phthalates and Respiratory Health in Five-Year-Old Boys: A Prospective Study
Conclusion: Ethyl-paraben, bisphenol A, 2,5-dichlorophenol, and DIDP tended to be associated with altered respiratory health, with ethyl-paraben and bisphenol A exhibiting some consistency across respiratory outcomes. The trends between bisphenol A pregnancy level and increased asthma and bronchiolitis/bronchitis rates in childhood were consistent with a previous cohort study. https://doi.org/10.1289/EHP1015 Received: 25 August 2016 Revised: 12 January 2017 Accepted: 26 January 2017 Published: 08 September 2017 Address correspondence to C. Vernet, Institute for Advanced Biosciences (IAB), Centre de Recherche INSERMâ€...
Source: EHP Research - September 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Long-Acting β2-Agonists and Risk of Hypertensive Disorders of Pregnancy: A Cohort Study
Conclusions The results of this study provide evidence suggesting the safety of LABAs for the treatment of asthma in pregnancy, in terms of the risks of HDP and preeclampsia/eclampsia.
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 26, 2017 Category: Allergy & Immunology Source Type: research

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid
Conclusion: We propose that when CFA arrives at the airway, it rapidly adsorbs AMPs and creates negative complexes, thereby decreasing the functional amount of AMPs capable of killing pathogens. These results provide a novel translational insight into an early mechanism for how ambient PM increases the susceptibility of the airways to bacterial infection. https://doi.org/10.1289/EHP876 Received: 27 July 2016 Revised: 30 December 2016 Accepted: 19 January 2017 Published: 05 July 2017 Address correspondence to A. P. Comellas, 6312 Pappajohn Biomedical Discovery Building. Newton Road, Iowa City, Iowa, USA, 52242; Teleph...
Source: EHP Research - July 6, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research