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A clinical audit of oral anticoagulant therapy in aged care residents with atrial fibrillation
Conclusion Many residents with non-valvular AF and significant risk of stroke were not receiving oral anticoagulation despite a lack of documented reason for non-prescribing. Non-vitamin K antagonists were widely prescribed but dosing of these agents could still be improved. There remains a need to improve anticoagulant prescribing for aged care residents and optimise stroke prevention in this population.
Source: International Journal of Clinical Pharmacy - April 13, 2020 Category: Drugs & Pharmacology Source Type: research

Cerebrovascular Disease Profiles of Culturally and Linguistically Diverse Communities in South Western Sydney and New South Wales
Conclusion: Greater rates of TIA/stroke were observed in specific CALD communities, with increased rates of cerebrovascular risk factors. Culturally specific, targeted interventions may bridge health inequalities in cerebrovascular disease.Cerebrovasc Dis
Source: Cerebrovascular Diseases - May 12, 2022 Category: Neurology Source Type: research

Ten-Year Trends in the Use of Oral Anticoagulants in Australian General Practice Patients With Atrial Fibrillation
Conclusions: Over the 10 years, OAC prescribing in high stroke risk patients with AF increased by one-third. There was considerable variation in OAC prescribing between general practices.
Source: Frontiers in Pharmacology - March 23, 2021 Category: Drugs & Pharmacology Source Type: research

Real World Experience of Direct Oral Anticoagulants with Comparison of Safety Outcomes to the Warfarin Era of Venous Thromboembolism Treatment
Conclusion:This retrospective audit shows that our local safety outcomes are comparable to clinical trials. Low dose anticoagulation and high falls risk (a surrogate marker of frailty) were significant risk factors for both clinically significant bleeding and thrombotic stroke in the DOAC population. These patients are likely frailer with greater co-morbidities and have shared risk factors for bleeding and stroke, suggesting that for these high risk patients, low dose anticoagulation does not negate their risk of complications and careful prescribing and close monitoring remain essential.The sub-comparison between VTE pati...
Source: Blood - November 21, 2018 Category: Hematology Authors: Brook, R., Aswapanyawongse, N., Lim, H. Y., Ho, P. Tags: 331. Pathophysiology of Thrombosis: Poster II Source Type: research

Epidemiology of atrial fibrillation
ConclusionsAlthough the prevalence of AF worldwide is increasing steadily, large variation can be seen between studies and countries. Further epidemiological studies should be undertaken globally, especially in Asian and African countries so that a better and more accurate picture of the incidence and prevalence of AF can be captured, to enable stroke prevention strategies to be appropriately implemented to prevent or reduce the risk of stroke, the most severe consequence of AF.
Source: International Journal of Clinical Practice - March 1, 2018 Category: Internal Medicine Authors: Hanis Zulkifly, Gregory Y. H. Lip, Deirdre A. Lane Tags: PERSPECTIVE Source Type: research

Combining Watchman left atrial appendage closure and catheter ablation for atrial fibrillation: multicentre registry results of feasibility and safety during implant and 30 days follow-up
ConclusionThe outcomes from these international, multicentre registries support the feasibility and safety of performing combined procedures of ablation and Watchman LAAC for patients with non-valvular AF and high stroke risk. Further data are needed on long-term outcomes for the hybrid technique on all-cause stroke and mortality.
Source: Europace - July 3, 2017 Category: Cardiology Source Type: research

Underusage of Oral Anticoagulation in Atrial Fibrillation: Can We Prevent More Strokes?
Atrial fibrillation (AF) is the most common sustained arrhythmia in Australia, affecting 2% of the population, and 6% of those over the age of 55 years [1]. The greatest contributor to morbidity and mortality in AF is its association with ischaemic stroke [2]. AF increases the risk of cardioembolic stroke five-fold, with an annual incidence of up to 7% [3]. There have been several validated tools developed to help individualise stroke risk, such as the CHADS2 [4], CHA2DS2-VASc [5], and more recently the CHA2DS2-VA score [6], all of which require the input of several vascular risk factors.
Source: Heart, Lung and Circulation - June 2, 2021 Category: Cardiology Authors: Karan Rao, Ravinay Bhindi Tags: Editorial Source Type: research

NOACs Now Mainstream for the Use of Anticoagulation in Non-Valvular Atrial Fibrillation in Australia.
The management of stroke risk in patients with non-valvular atrial fibrillation has changed over the past few years. This change has occurred due to the introduction of novel oral anticoagulants (NOACs) such as apixaban, rivaroxaban and dabigatran for the management of non-valvular atrial fibrillation. These agents have shown comparable stroke risk reduction to warfarin in large international multicentre trials [1 –3]. This has changed the clinical practice of many treating physicians since their introduction from 2011 to 2013.
Source: Heart, Lung and Circulation - March 22, 2018 Category: Cardiology Authors: Derk Pol, Claire Curtis, Satish Ramukumar, Logan Bittinger Tags: Brief Communication Source Type: research

NOACs Now Mainstream for the Use of Anticoagulation in Non-Valvular Atrial Fibrillation in Australia
The management of stroke risk in patients with non-valvular atrial fibrillation has changed over the past few years. This change has occurred due to the introduction of novel oral anticoagulants (NOACs) such as apixaban, rivaroxaban and dabigatran for the management of non-valvular atrial fibrillation. These agents have shown comparable stroke risk reduction to warfarin in large international multicentre trials [1 –3]. This has changed the clinical practice of many treating physicians since their introduction from 2011 to 2013.
Source: Heart, Lung and Circulation - March 22, 2018 Category: Cardiology Authors: Derk Pol, Claire Curtis, Satish Ramukumar, Logan Bittinger Tags: Brief Communication Source Type: research

National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the diagnosis and management of atrial fibrillation 2018.
Authors: Brieger D, Amerena J, Attia JR, Bajorek B, Chan KH, Connell C, Freedman B, Ferguson C, Hall T, Haqqani HM, Hendriks J, Hespe CM, Hung J, Kalman JM, Sanders P, Worthington J, Yan T, Zwar NA Abstract INTRODUCTION: Atrial fibrillation (AF) is increasing in prevalence and is associated with significant morbidity and mortality. The optimal diagnostic and treatment strategies for AF are continually evolving and care for patients requires confidence in integrating these new developments into practice. These clinical practice guidelines will assist Australian practitioners in the diagnosis and management of adult ...
Source: Medical Journal of Australia - August 3, 2018 Category: General Medicine Tags: Med J Aust Source Type: research

Atrial Fibrillation and Indigenous Australians: A way Forward for Timely and Effective Screening and Treatment
Background: The leading cause of death for Indigenous Australians is cardiovascular disease, including stroke. Atrial Fibrillation (AF) increases stroke risk 5 –7 fold. Early detection and treatment of AF in Caucasians has proven feasible. Aim: To estimate AF prevalence in community settings and examine feasibility of using a handheld single-lead ECG device (iECG) for Indigenous Australians.
Source: Heart, Lung and Circulation - June 23, 2019 Category: Cardiology Authors: K. Gwynne, J. Gwynn, H. Finlayson, S. Hamilton, M. Lawrence, R. MacNiven, L. Neubeck, B. Rambaldini, R. Rodrigues, K. Taylor, S. Thompson, B. Freedman Tags: 514 Source Type: research

Should This Patient Be Screened for Atrial Fibrillation?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 Dec 03;171(11):828-836 Authors: Burns RB, Zimetbaum P, Lubitz SA, Smetana GW Abstract Atrial fibrillation (AFib) is the most common type of cardiac arrhythmia, affecting 2.7 million to 6.1 million persons in the United States. Although some persons with AFib have no symptoms, others do. For those without symptoms, AFib may be detected by 12-lead electrocardiogram (ECG), single-lead monitors (such as ambulatory blood pressure monitors and pulse oximeters), or consumer devices (such as wearable monitors and smartphones). Pulse pa...
Source: Annals of Internal Medicine - December 2, 2019 Category: Internal Medicine Authors: Burns RB, Zimetbaum P, Lubitz SA, Smetana GW Tags: Ann Intern Med Source Type: research

Predictors of Anticoagulation Use in Indigenous and Non-Indigenous Australians with Atrial Fibrillation
Prior studies have demonstrated that anticoagulation underutilisation for atrial fibrillation (AF) and elevated stroke risk is common. However, there is little data on factors associated with appropriate anticoagulation, particularly in Indigenous Australians who face a disproportionate burden of AF and stroke. We thus sought to determine factors associated with anticoagulation use in Australians with AF.
Source: Heart, Lung and Circulation - October 29, 2020 Category: Cardiology Authors: Simon Rocheleau, Celine Gallagher, Bradley M. Pitman, Samuel J. Tu, Nicole Hanna-Rivero, Nicholas Clarke, Dominik Linz, Jeroen M. Hendriks, Melissa E. Middeldorp, Rajiv Mahajan, Dennis H. Lau, Kurt C. Roberts-Thomson, Prashanthan Sanders, Christopher X. W Tags: Original Article Source Type: research

Utility estimations of health states of older Australian women with atrial fibrillation using SF-6D
ConclusionThis study presents health utility estimates for older women with AF. These estimates can be used in future clinical and economic research. The study also highlights better health utilities for women living in regional and remote areas, which requires further exploration.
Source: Quality of Life Research - February 7, 2021 Category: Health Management Source Type: research

Patient-Led Mass Screening for Atrial Fibrillation in the Older Population Using Handheld Electrocardiographic Devices Integrated With a Clinician-Coordinated Remote Central Monitoring System: Protocol for a Randomized Controlled Trial and Process Evaluation
CONCLUSIONS: By incorporating an integrated health care approach involving patient empowerment, centralized clinician-coordinated ECG monitoring, and facilitation of primary care and specialist services, it is possible to diagnose and treat AF early to reduce stroke risk. This study will provide new information on how to implement AF screening using digital health technology practicably and feasibly for older and frail populations residing in the community.TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry ACTRN12621000184875; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=380877.INTERNAT...
Source: Rural Remote Health - February 1, 2022 Category: Rural Health Authors: Kam Cheong Wong Tu N Nguyen Simone Marschner Samual Turnbull Mason Jenner Burns Jia Yi Anna Ne Vishal Gopal Anupama Balasuriya Indrawansa Steven A Trankle Tim Usherwood Saurabh Kumar Richard I Lindley Clara K Chow Source Type: research

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