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Condition: Arteriosclerosis

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Total 577 results found since Jan 2013.

Vascular Regeneration in Peripheral Artery Disease.
Abstract Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only mod...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 20, 2020 Category: Cardiology Authors: Cooke JP, Meng S Tags: Arterioscler Thromb Vasc Biol Source Type: research

Paraoxonase-1 and other factors related to oxidative stress in psoriasis.
Conclusions: Psoriasis promotes arteriosclerosis development by decreasing the levels of antiatherogenic and increasing the levels of proatherogenic agents. Adverse changes in psoriatic patients involve activity of paraoxonase-1, levels of α-tocopherol, uric acid, homocysteine as compared to healthy individuals selected by their age, BMI and abdominal circumference value. PMID: 32467691 [PubMed]
Source: Advances in Dermatology and Allergology - May 31, 2020 Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research

Cardiorenal Protection With the Newer Antidiabetic Agents in Patients With Diabetes and Chronic Kidney Disease: A Scientific Statement From the American Heart Association.
lar Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Lifestyle and Cardiometabolic Health Abstract Chronic kidney disease (CKD) with type 2 diabetes (T2D) is a major public health problem, resulting in significant cardiovascular and kidney adverse outcomes worldwide. Despite the widespread use of standard-of-care therapies for CKD with T2D over the past few decades, rates of progression to end-stage kidney disease remain high with no beneficial impact on its accompanying burden of cardiovascular disease. The advent of the newer classes of antihyperglycemic agent...
Source: Circulation - September 27, 2020 Category: Cardiology Authors: Rangaswami J, Bhalla V, de Boer IH, Staruschenko A, Sharp JA, Singh RR, Lo KB, Tuttle K, Vaduganathan M, Ventura H, McCullough PA, American Heart Association Council on the Kidney in Cardiovascular Disease; Council on Arteriosclerosis, Thrombosis and Vasc Tags: Circulation Source Type: research

Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity.
CONCLUSIONS: CD8+ TSCM cells are increased in humans with high CVD. As these TSCM cells promote atherosclerosis, targeting them may attenuate atherosclerotic plaque progression. PMID: 33054398 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - October 15, 2020 Category: Cardiology Authors: Padgett LE, Dinh HQ, Wu R, Gaddis DE, Araujo DJ, Winkels H, Nguyen A, McNamara CA, Hedrick CC Tags: Arterioscler Thromb Vasc Biol Source Type: research

Arterial Thrombotic Complications of Tyrosine Kinase Inhibitors.
Abstract Abnormal expression or function of several classes of kinases contribute to the development of many types of solid and hematologic malignancies. TKs (tyrosine kinases) in particular play a role in tumor growth, metastasis, neovascularization, suppression of immune surveillance, and drug resistance. TKIs (tyrosine kinase inhibitors) targeted to TKs such as BCR-ABL1, VEGF receptors, PDGF receptors, have transformed therapy of certain forms of cancer by providing excellent efficacy with relatively low adverse event rates. Yet some of these agents have been associated with high rates of vascular events, presu...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 4, 2020 Category: Cardiology Authors: Wu MD, Moslehi JJ, Lindner JR Tags: Arterioscler Thromb Vasc Biol Source Type: research

Susceptibility Vessel Sign in Deep Perforating Arteries in Patients with Recent Small Subcortical Infarcts
Recent small subcortical infarcts (RSSI) are the neuroimaging evidence of an acute infarction resulting from the occlusion of deep perforating arteries of the brain. RSSIs are considered one of the main radiological features of cerebral small vessel disease on magnetic resonance imaging (MRI), along with other chronic markers such as white matter hyperintensities (WMH), lacunae, cerebral microbleeds, enlarged perivascular spaces, and brain atrophy.1 The pathophysiology of cerebral small vessel disease is still unknown, but many mechanisms seem to be implied, such as arteriosclerosis, hypoperfusion, blood-brain barrier leak...
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2020 Category: Neurology Authors: Salvatore Rudilosso, Marta Olivera, Diana Esteller, Carlos Laredo, Sergio Amaro, Laura Llull, Arturo Ren ú, Víctor Obach, Víctor Vera, Alejandro Rodríguez, Jordi Blasco, Antonio López-Rueda, Xabier Urra, Ángel Chamorro Source Type: research

Ambient Air Pollution and Atherosclerosis: Insights Into Dose, Time, and Mechanisms.
Abstract Ambient air pollution due to particulate matter <2.5 μ is the leading environmental risk factor contributing to global mortality, with a preponderant majority of these deaths attributable to atherosclerotic cardiovascular disease (ASCVD) causes such as stroke and myocardial infarction. Epidemiological studies in humans have provided refined estimates of exposure risk with evidence suggesting that risk association with particulate matter <2.5 levels and ASCVD continues at levels well below air quality guidelines in North America and Europe. Mechanistic studies in animals and humans have provided a f...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 17, 2020 Category: Cardiology Authors: Bevan GH, Al-Kindi S, Brook RD, Münzel T, Rajagopalan S Tags: Arterioscler Thromb Vasc Biol Source Type: research

COMP (Cartilage Oligomeric Matrix Protein) Neoepitope: A Novel Biomarker to Identify Symptomatic Carotid Stenosis.
CONCLUSIONS: Degradation of COMP may be associated with atherosclerosis progression and generation of a specific COMP fragment-COMPneo. This may represent a novel biomarker that together with COMPtotal and other risk-markers could be used to identify symptomatic carotid stenosis. PMID: 33472398 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - January 21, 2021 Category: Cardiology Authors: Sandstedt J, Vargmar K, Björkman K, Ruetschi U, Bergström G, Hultén LM, Skiöldebrand E Tags: Arterioscler Thromb Vasc Biol Source Type: research

Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association.
ouncil on Cardiovascular and Stroke Nursing; and Council on Lifestyle and Cardiometabolic Health Abstract As clinicians delivering health care, we are very good at treating disease but often not as good at treating the person. The focus of our attention has been on the specific physical condition rather than the patient as a whole. Less attention has been given to psychological health and how that can contribute to physical health and disease. However, there is now an increasing appreciation of how psychological health can contribute not only in a negative way to cardiovascular disease (CVD) but also in a positive...
Source: Circulation - January 25, 2021 Category: Cardiology Authors: Levine GN, Cohen BE, Commodore-Mensah Y, Fleury J, Huffman JC, Khalid U, Labarthe DR, Lavretsky H, Michos ED, Spatz ES, Kubzansky LD, American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Tags: Circulation Source Type: research

Genetic predisposition and bioinformatics analysis of ATP-sensitive potassium channels polymorphisms with the risks of elevated apolipoprotein B serum levels and its related arteriosclerosis cardiovascular disease
Aging (Albany NY). 2021 Mar 3;13. doi: 10.18632/aging.202628. Online ahead of print.ABSTRACTSerum concentration of apolipoprotein B (Apo B) is causally associated with arteriosclerosis cardiovascular disease (ASCVD) risk. Whether ATP-sensitive potassium channels (KATP) variants predict the risk of increased Apo B concentration (≥ 80 mg/dL) and related ASCVD remain less clear. We recruited 522 subjects with elevated Apo B concentration (≥ 80 mg/dL) and 522 counterpart subjects (< 80 mg/dL) from South China to assess the associations of KATP variants (rs11046182, rs78148713, rs145456027 and rs147265929) with the risks...
Source: Aging - March 9, 2021 Category: Biomedical Science Authors: Cheng Liu Tianwang Guan Yanxian Lai Junfang Zhan Yan Shen Source Type: research

Adverse Pregnancy Outcomes and Cardiovascular Disease Risk: Unique Opportunities for Cardiovascular Disease Prevention in Women: A Scientific Statement From the American Heart Association
Circulation. 2021 Mar 29:CIR0000000000000961. doi: 10.1161/CIR.0000000000000961. Online ahead of print.ABSTRACTThis statement summarizes evidence that adverse pregnancy outcomes (APOs) such as hypertensive disorders of pregnancy, preterm delivery, gestational diabetes, small-for-gestational-age delivery, placental abruption, and pregnancy loss increase a woman's risk of developing cardiovascular disease (CVD) risk factors and of developing subsequent CVD (including fatal and nonfatal coronary heart disease, stroke, peripheral vascular disease, and heart failure). This statement highlights the importance of recognizing APOs...
Source: Circulation - March 29, 2021 Category: Cardiology Authors: Nisha I Parikh Juan M Gonzalez Cheryl A M Anderson Suzanne E Judd Kathryn M Rexrode Mark A Hlatky Erica P Gunderson Jennifer J Stuart Dhananjay Vaidya American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombos Source Type: research

Relationship Between Central Artery Stiffness, Brain Arterial Dilation, and White Matter Hyperintensities in Older Adults: The ARIC Study
CONCLUSIONS: In this examination of older adults from the general population, larger, plaque-free arterial diameters in the middle cerebral circulation were associated with greater WMH volume, particularly among participants with elevated central artery stiffness. Strategies to reduce central artery stiffness may mitigate the association between cerebrovascular outward remodeling and microvascular damage.PMID:33882687 | DOI:10.1161/ATVBAHA.120.315692
Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 22, 2021 Category: Cardiology Authors: Melissa C Caughey Ye Qiao Michelle L Meyer Priya Palta Kunihiro Matsushita Hirofumi Tanaka Bruce A Wasserman Gerardo Heiss Source Type: research