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A case of refractary epilepsy and related pain due to dysmenorrhea solved with loading dose of lacosamide: clinical and neurophysiological correlates.
Abstract  In most cases, the etiology of epilepsy is unknown, although some individuals may develop epilepsy as a result of certain brain injuries, following a stroke, a brain tumor or because of drugs and alcohol. Even some rare genetic mutations may be related to the onset of the condition. Seizures are the result of excessive and abnormal activity of neurons in the cerebral cortex. In this case report we show a clinical case of refractory epilepsy due to pain related to uncontrolled dysmenorrhea. The patient, 43 yrs old, had a history of epilepsy of 20 years and ovarian cancer. She was treated with lamotrigine...
Source: Acta Bio-Medica : Atenei Parmensis - October 23, 2017 Category: General Medicine Authors: Marchitto N, Ceratti U, Dalmaso S, Raimondi G Tags: Acta Biomed Source Type: research

Safety of once- or twice-daily dosing of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with nonvalvular atrial fibrillation: A NOAC-TR study.
In this study, we investigated the adherence to once- or twice-daily dosing of NOACs and the risk of bleeding in nonvalvular atrial fibrillation (NVAF) patients. This multicenter cross-sectional study, conducted between 1 September 2015 and 28 February 2016, included 2214 patients receiving NOACs for at least 3 months, due to NVAF. Patients receiving once-daily or twice-daily NOAC doses were 1:1 propensity score matched for baseline demographic characteristics and the presence of other diseases. The medication adherence was assessed by the 8-item Morisky Medication Adherence Scale. Risk factors were investigated in relatio...
Source: Bosnian Journal of Basic Medical Sciences - October 3, 2017 Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research

Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study
Publication date: Available online 29 August 2017 Source:The Lancet Author(s): Victoria Miller, Andrew Mente, Mahshid Dehghan, Sumathy Rangarajan, Xiaohe Zhang, Sumathi Swaminathan, Gilles Dagenais, Rajeev Gupta, Viswanathan Mohan, Scott Lear, Shrikant I Bangdiwala, Aletta E Schutte, Edelweiss Wentzel-Viljoen, Alvaro Avezum, Yuksel Altuntas, Khalid Yusoff, Noorhassim Ismail, Nasheeta Peer, Jephat Chifamba, Rafael Diaz, Omar Rahman, Noushin Mohammadifard, Fernando Lana, Katarzyna Zatonska, Andreas Wielgosz, Afzalhussein Yusufali, Romaina Iqbal, Patricio Lopez-Jaramillo, Rasha Khatib, Annika Rosengren, V Raman Kutty, Wei Li...
Source: The Lancet - August 31, 2017 Category: General Medicine Source Type: research

Artery of Percheron infarction: a case report
ConclusionsArtery of Percheron infarcts are rare. The radiological diagnosis can initially often be judged as normal and in combination with variability in the neurological symptoms it is a rather difficult condition to diagnose. For these reasons few clinicians have much experience with this type of infarct, which may delay diagnosis and initiation of appropriate treatment.
Source: Journal of Medical Case Reports - August 12, 2017 Category: General Medicine Source Type: research

Smoking and blood pressure: A complex relationship.
Abstract Hypertension and tobacco smoking are two major modifiable risk factors for atheromatous disease and its cardiovascular complications. If systolic hypertension (SBP≥140mmHg and DBP<90mmHg) is the leading risk factor for stroke, smoking (nicotine) has a more powerful impact on coronary events, aortic aneurysms, and peripheral artery disease. Smoking can transiently modify the regulation of blood pressure (BP) by a swift effect on the autonomic nervous system. It also accelerates arterial aging, which plays a role in chronic hypertension. Chronic sympathetic activation induced by tobacco smoking also ha...
Source: Presse Medicale - July 28, 2017 Category: General Medicine Authors: Madika AL, Mounier-Vehier C Tags: Presse Med Source Type: research

Cirrhosis Could Raise Stroke Risk
MONDAY, June 5, 2017 -- Cirrhosis -- a stiffening of liver tissue that ' s often tied to excessive drinking of alcohol -- may also raise an older person ' s odds for a stroke, a new study suggests. " In a nationally representative sample of elderly...
Source: Drugs.com - Daily MedNews - June 5, 2017 Category: General Medicine Source Type: news

Utility of Hemoccult Testing Before Therapeutic Anticoagulation in Venous Thromboembolism.
CONCLUSIONS: Despite its beneficial negative predictive value, gFOBT before initiating therapeutic anticoagulation is unlikely to change the management of patients without evidence of overt GIB. PMID: 28464181 [PubMed - in process]
Source: Southern Medical Journal - May 4, 2017 Category: Journals (General) Tags: South Med J Source Type: research

Translating the WHO 25x25 goals into a UK context: the PROMISE modelling study
Conclusions The global premature mortality targets are a potentially achievable goal for countries such as the UK that can capitalise on many decades of effort in prevention and treatment. High morbidity diseases and diseases in later life are not addressed in the Global NCD Action Plan and targets, but must also be considered a priority for prevention in the UK where the population is ageing and the costs of health and social care are rising.
Source: BMJ Open - April 4, 2017 Category: Journals (General) Authors: Cobiac, L. J., Scarborough, P. Tags: Open access, Epidemiology, Health policy, Public health Research Source Type: research

Trends in population blood pressure and determinant factors for population blood pressure.
Authors: Andersen UO Abstract Strategies to reduce the burden of blood pressure attributable diseases require knowledge of secular trend in PBP and its determinants. The issues were investigated in the Copenhagen City Heart Study. The design of CCHS is a repeated measures study. Such designs are uniquely suited to studying changes of an outcome and what risk factors may be associated with that outcome. Repeated measures studies are very well suited for trend analysis by using mixed effect analyses. SBP decreased about 2 mmHg in 25 years. The risk factors age, gender and BMI were found valid as determinant factors f...
Source: Danish Medical Journal - March 8, 2017 Category: Journals (General) Tags: Dan Med J Source Type: research

2017 Taiwan lipid guidelines for high risk patients
Publication date: Available online 24 February 2017 Source:Journal of the Formosan Medical Association Author(s): Yi-Heng Li, Kwo-Chang Ueng, Jiann-Shing Jeng, Min-Ji Charng, Tsung-Hsien Lin, Kuo-Liong Chien, Chih-Yuan Wang, Ting-Hsing Chao, Ping-Yen Liu, Cheng-Huang Su, Shih-Chieh Chien, Chia-Wei Liou, Sung-Chun Tang, Chun-Chuan Lee, Tse-Ya Yu, Jaw-Wen Chen, Chau-Chung Wu, Hung-I Yeh In Taiwan, the prevalence of hyperlipidemia increased due to lifestyle and dietary habit changes. Low density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) are all significant predicting factors of ...
Source: Journal of the Formosan Medical Association - February 24, 2017 Category: Journals (General) Source Type: research

2017 Taiwan lipid guidelines for high risk patients.
Abstract In Taiwan, the prevalence of hyperlipidemia increased due to lifestyle and dietary habit changes. Low density lipoprotein cholesterol (LDL-C) and non-high density lipoprotein cholesterol (non-HDL-C) are all significant predicting factors of coronary artery disease in Taiwan. We recognized that lipid control is especially important in patients with existed atherosclerotic cardiovascular diseases (ASCVD), including coronary artery disease (CAD), ischemic stroke and peripheral arterial disease (PAD). Because the risk of ASCVD is high in patients with diabetes mellitus (DM), chronic kidney disease (CKD) and f...
Source: J Formos Med Assoc - February 23, 2017 Category: Journals (General) Authors: Li YH, Ueng KC, Jeng JS, Charng MJ, Lin TH, Chien KL, Wang CY, Chao TH, Liu PY, Su CH, Chien SC, Liou CW, Tang SC, Lee CC, Yu TY, Chen JW, Wu CC, Yeh HI, Writing Group of 2017 Taiwan Lipid Guidelines for High Risk Patients Tags: J Formos Med Assoc Source Type: research

Myocardial infarction in the Wisconsin Longitudinal Study: the interaction among environmental, health, social, behavioural and genetic factors
Conclusions Together these results indicate important differences in factors associated with MI between the sexes, that combinations of factors greatly influence the likelihood of MI, that MI-associated factors change and associations weaken after 65 years of age in both sexes, and that the limited genotypes assessed were secondary to environmental, health, social and behavioral factors.
Source: BMJ Open - January 22, 2017 Category: Journals (General) Authors: Gonzales, T. K., Yonker, J. A., Chang, V., Roan, C. L., Herd, P., Atwood, C. S. Tags: Open access, Cardiovascular medicine, Epidemiology, Public health Research Source Type: research

Pathophysiology of obstructive sleep apnea syndrome and its cardiometabolic consequences.
Abstract Obstructive sleep apnoea syndrome (OSAS) is characterized by recurrent partial or complete pharyngeal collapses during sleep. The pathophysiology of OSAS is complex and multifactorial. Factors influencing upper airway patency include a reduction in upper airway dimensions that can result from both anatomical and functional alterations (obesity, fluid shift or maxillo-facial structural changes), and increased pharyngeal collapsibility owing to reduced neuromuscular compensation and lack of the pharyngeal protective reflex during sleep. Severe OSAS is associated with a high cardiometabolic risk. Obstructive...
Source: Presse Medicale - January 22, 2017 Category: Journals (General) Authors: Destors M, Tamisier R, Galerneau LM, Lévy P, Pepin JL Tags: Presse Med Source Type: research

Comparison of self-perceived cardiovascular disease risk among smokers with Framingham and PROCAM scores: a cross-sectional analysis of baseline data from a randomised controlled trial
Conclusions Among smokers, misperception of their 10-year cardiovascular risk is common, with one-fifth underestimating it. These findings may help physicians target patients with such characteristics to help them change their health behaviour and adherence to risk-reduction therapy. Trial registration number NCT00548665; Post-results.
Source: BMJ Open - January 5, 2017 Category: Journals (General) Authors: Desgraz, B., Collet, T.-H., Rodondi, N., Cornuz, J., Clair, C. Tags: Open access, Cardiovascular medicine, Epidemiology, General practice / Family practice, Smoking and tobacco Research Source Type: research

Ideal cardiovascular health score and incident end-stage renal disease in a community-based longitudinal cohort study: the Kailuan Study
Conclusions A low CVH score significantly increased the risk of incident ESRD. Risk factors for cardiovascular events may also be associated with an increased risk for kidney failure.
Source: BMJ Open - November 28, 2016 Category: Journals (General) Authors: Han, Q. L., Wu, S. L., Liu, X. X., An, S. S., Wu, Y. T., Gao, J. S., Chen, S. H., Liu, X. K., Zhang, Q., Mao, R. Y., Shang, X. M., Jonas, J. B. Tags: Open access, Cardiovascular medicine, Epidemiology, Nutrition and metabolism, Occupational and environmental medicine, Renal medicine Research Source Type: research

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