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Specialty: Neuroscience
Condition: Thrombosis

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Total 164 results found since Jan 2013.

Impact of Carotid Atherosclerosis Combined with Hypercholesterolemia on Cerebral Microvessels and Brain Parenchyma in a New Complex Rat Model.
The objective of this study was to develop a new model of hypercholesterolemia plus carotid injury and to investigate the impact of carotid atherosclerosis combined with hypercholesterolemia in the rat brain. The complex rat model was developed by carotid injury induced by an air-drying endothelial denudation method after high cholesterol diet for 2 weeks. Plasma cholesterol, carotid pathomorphology, oxidative stress and inflammation in cerebral microvessels and brain parenchyma were measured at 7, 14 and 28 days after carotid surgery. The results showed that plasma concentrations of total cholesterol and low density lip...
Source: Neurochemical Research - January 29, 2014 Category: Neuroscience Authors: Zhang L, Ya B, Yang P, Sun F, Zhang L, Li Y, Li L Tags: Neurochem Res Source Type: research

Cerebral Thrombosis and Myeloproliferative Neoplasms
Abstract Myeloproliferative neoplasms (MPN) are acquired clonal disorders characterized by the proliferation of bone marrow myeloid cells. Different somatic mutations have been recently associated with MPN, the most common being JAK-2 V617F. Among MPN, polycythemia vera and essential thrombocythemia are particularly associated with an increased risk to develop thrombotic complications, either arterial or venous. Cerebrovascular events (stroke and transient ischemic attacks) are prevalent, accounting for approximately two-thirds of all events. Also cerebral vein thrombosis can complicate MPN and can be the first m...
Source: Current Neurology and Neuroscience Reports - September 14, 2014 Category: Neuroscience Source Type: research

ID 366 – Cerebral venous thrombosis (CVT) in a female patient with severe obstructive sleep apnea (OSAS): Case presentation
Obstructive sleep apnea syndrome is reported to be a risk factor for arterial ischemic stroke, however, relationship between OSAS and cerebral venous thrombosis (CVT) remains uncertain.
Source: Clinical Neurophysiology - February 11, 2016 Category: Neuroscience Authors: H. Rashed, A. Marei, M. Tork, A. Abdelnasser Source Type: research

tPA promotes cortical neuron survival via mTOR-dependent mechanisms
We report here that tPA treatment results in a time-dependent neuroprotective effect on postnatal cortical neurons that relies predominantly on Janus kinase (JAK) and mammalian target of rapamycin (mTOR) signaling mechanisms. Taken together, these data suggest that tPA promotes neuroprotection in a temporally-regulated manner and that both JAK and mTOR signaling effectors are critical mediators of this neuroprotective effect. The results suggest the possibility of targeting these defined mechanisms to potentially expand the therapeutic window for tPA.
Source: Molecular and Cellular Neuroscience - March 18, 2016 Category: Neuroscience Source Type: research

Neurological complications of acute multifocal placoid pigment epitheliopathy
The objective of this patient series is to describe the neurological complications of AMPPE. We retrospectively identified patients with neurological complications of AMPPE seen at Auckland Hospital between 2008 and 2013 and summarised cases in the literature between 1976 and 2013. We identified five patients with neurological complications of AMPPE at Auckland Hospital and 47 reported patients. These patients demonstrated a spectrum of neurological involvement including isolated headache, stroke or transient ischaemic attack, seizures, venous sinus thrombosis, optic neuritis, sensorineural hearing loss and peripheral vest...
Source: Journal of Clinical Neuroscience - May 11, 2016 Category: Neuroscience Source Type: research

New mechanical thrombectomy model in the rabbit: A feasibility study
Conclusions The novel small animal model for mechanical thrombectomy in rabbit is technically feasible and cheap. It offers comparable vessel diameters to cranial arteries and closely mimics human coagulation system.
Source: Journal of Neuroscience Methods - July 28, 2016 Category: Neuroscience Source Type: research

Oxidative stress and glutamate excitotoxicity contribute to apoptosis in cerebral venous sinus thrombosis
Publication date: November 2016 Source:Neurochemistry International, Volume 100 Author(s): Hari Shanker Tiwari, Usha Kant Misra, Jayantee Kalita, Akanksha Mishra, Shubha Shukla Cerebral venous sinus thrombosis (CVST) is an important cause of stroke in young especially in the developing countries. There is paucity of studies on the mechanism of cell damage in CVST. Aim of this study is to explore the role of glutamate excitotoxicity, oxidative stress; and apoptosis in an experimental model of CVST. Cerebral venous sinus thrombosis was induced by putting a strip of filter paper soaked in 40% ferric chloride on superior sagi...
Source: Neurochemistry International - September 20, 2016 Category: Neuroscience Source Type: research

Acute bithalamic infarct manifesting as sleep-like coma: A diagnostic challenge
Publication date: December 2016 Source:Journal of Clinical Neuroscience, Volume 34 Author(s): Asaf Honig, Ruth Eliahou, Roni Eichel, Ari Aharon Shemesh, Tamir Ben-Hur, Eitan Auriel Bilateral thalamic infarction (BTI) typically presents as a sleep-like coma (SLC) without localizing signs, posing a diagnostic challenge that may lead the treating physician to search for toxic or metabolic causes and delay treatment. We review our experience with BTI of different etiologies, and emphasize the critical role of timely imaging, diagnosis, and management in a series of 12 patients with a presentation of SLC and acute BTI who were...
Source: Journal of Clinical Neuroscience - November 10, 2016 Category: Neuroscience Source Type: research

Facial palsy in cerebral venous thrombosis: An atypical case in a young girl
Ayse KartalJournal of Pediatric Neurosciences 2017 12(2):160-161Cerebral venous thrombosis (CVT) is a rare and potentially life-threating cause of stroke. A number of etiologies and risk factors for CVT have been identified so far. These include head trauma, local and systemic infectious diseases, malignancies, autoimmune diseases, and oral contraceptive use. The most common clinical symptoms are headache and changes in consciousness. Cranial nerve palsy in CVT is uncommon, and there are very few reports of facial nerve palsy. This case report highlights an atypical manifestation in a CVT patient, who presented with periph...
Source: Journal of Pediatric Neurosciences - August 10, 2017 Category: Neuroscience Authors: Ayse Kartal Source Type: research

Down syndrome with moyamoya disease: A case series
Pawan Kumar, Inusha Panigrahi, Naveen Sankhyan, Chirag Ahuja, Prasoon K GoyadiJournal of Pediatric Neurosciences 2018 13(2):201-204 Down syndrome (DS), resulting from trisomy 21, is a common cause of mental retardation. Around 20,000 babies with DS are born every year in India. There is an increased risk of cerebral infarction in children with DS, the common causes being thromboembolism secondary to atrioventricular canal defects, right-to-left shunting, myocardial dysmotility, or cardiac valvular abnormalities. Stroke due to other causes can also occur in patients with DS, and one of these is moyamoya disease. This can b...
Source: Journal of Pediatric Neurosciences - July 5, 2018 Category: Neuroscience Authors: Pawan Kumar Inusha Panigrahi Naveen Sankhyan Chirag Ahuja Prasoon K Goyadi Source Type: research

Intracranial hypertension related to cerebral venous thrombosis; and acute ischemic stroke with micro-infarcts associated with IgG4-related disease
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Source: International Journal of Neuroscience - April 13, 2018 Category: Neuroscience Authors: Esme Ekizoglu Oguzhan Coban Cagri Ulukan Duygu Gezen Ak Erdin ç Dursun Erdem Tuzun Betul Baykan Source Type: research

Impact of venous thromboembolism during admission for meningioma surgery on hospital charges and postoperative complications
Publication date: Available online 9 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Eleonora F. Spinazzi, Darshan Shastri, Milap Raikundalia, Nicole A. Silva, Jean Anderson Eloy, James K. LiuAbstractSurgical resection of meningiomas has been associated with high rates of venous thromboembolic events (VTE) as compared with all other intracranial tumors. There is a paucity of data regarding the clinical complications and comorbidities associated with this cohort yet the underlying pathophysiological mechanism for this tumor-specific finding remains unclear. Our goal was to determine the various impacts of VTE...
Source: Journal of Clinical Neuroscience - October 9, 2018 Category: Neuroscience Source Type: research

Tissue Plasminogen Activator Causes Brain Microvascular Endothelial Cell Injury After Oxygen Glucose Deprivation by Inhibiting Sonic Hedgehog Signaling.
Abstract The thrombolytic activity of tissue plasminogen activator (tPA) has undisputed benefits. However, the documented neurotoxicity of tPA raises important issues. Currently, common treatments for stroke might not be optimum if exogenous tPA can pass through the blood-brain barrier and enter the brain, thus adding to the deleterious effects of tPA within the cerebral parenchyma. Here, we determined whether tPA could damage brain microvascular endothelial cells (BMECs) during cerebral ischemia. We showed that treatment of BMECs with tPA decreased trans-endothelial electrical resistance and cell proliferation, a...
Source: Neurochemical Research - December 14, 2018 Category: Neuroscience Authors: Gong P, Li M, Zou C, Tian Q, Xu Z Tags: Neurochem Res Source Type: research

Neurologic Complications of Sickle Cell Disease
AbstractPurpose of ReviewSickle cell anemia is a multiorgan disease with acute and chronic complications. Involvement of the central nervous system (CNS) is associated with increased mortality and morbidity. This review highlights the broad spectrum of neurological complications seen in patients with sickle cell disease.Recent FindingsIncreasing recognition of neurological complications has led to improved diagnostic and treatment options throughout the years. Neurologic complications in sickle cell disease include silent cerebral ischemia, ischemic/hemorrhagic stroke, moyamoya syndrome, posterior reversible encephalopathy...
Source: Current Neurology and Neuroscience Reports - February 28, 2019 Category: Neuroscience Source Type: research