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Cardiac Magnetic Resonance Imaging Findings Predict Major Adverse Events in Apical Hypertrophic Cardiomyopathy
Conclusions:Within our population of apical HCM patients, the extent of LGE and the presence of an apical aneurysm identified by cardiac MRI were both significant predictors of major adverse clinical events.
Source: Journal of Thoracic Imaging - October 24, 2014 Category: Radiology Tags: Original Articles Source Type: research

Advantages of susceptibility‐weighted magnetic resonance sequences in the visualization of intravascular thrombi in acute ischemic stroke
ConclusionsSWAN was more sensitive than T2* in the visualization of SVS in the intracranial arteries during the acute phase of ischemic stroke. Our study shows that the low number of SVS visualized using T2* in previous studies is probably related to a lack of sensitivity of the sequence, rather than to the nature or age of the thrombus. The greater sensitivity of SWAN seems to be linked to the visualization of SVS in cases of small thrombi.
Source: International Journal of Stroke - October 1, 2014 Category: Neurology Authors: R. Allibert, C. Billon Grand, F. Vuillier, F. Cattin, E. Muzard, A. Biondi, T. Moulin, E. Medeiros Tags: Short Report Source Type: research

Cervical Arterial Dissections and Association With Cervical Manipulative Therapy: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Conclusions— CD is an important cause of ischemic stroke in young and middle-aged patients. CD is most prevalent in the upper cervical spine and can involve the internal carotid artery or vertebral artery. Although current biomechanical evidence is insufficient to establish the claim that CMT causes CD, clinical reports suggest that mechanical forces play a role in a considerable number of CDs and most population controlled studies have found an association between CMT and VAD stroke in young patients. Although the incidence of CMT-associated CD in patients who have previously received CMT is not well established, an...
Source: Stroke - September 22, 2014 Category: Neurology Authors: Biller, J., Sacco, R. L., Albuquerque, F. C., Demaerschalk, B. M., Fayad, P., Long, P. H., Noorollah, L. D., Panagos, P. D., Schievink, W. I., Schwartz, N. E., Shuaib, A., Thaler, D. E., Tirschwell, D. L., on behalf of the American Heart Association Strok Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research

Thrombolysis in Ischemic Stroke Without Arterial Occlusion at Presentation Clinical Sciences
Conclusions— This study provides crucial data that patients with ischemic stroke who do not have visible arterial occlusion at presentation may benefit from thrombolysis.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Lahoti, S., Gokhale, S., Caplan, L., Michel, P., Samson, Y., Rosso, C., Limaye, K., Hinduja, A., Singhal, A., Ali, S., Pettigrew, L. C., Kryscio, R., Dedhia, N., Hastak, S., Liebeskind, D. S. Tags: Cerebral Lacunes, Embolic stroke, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Thrombolysis Clinical Sciences Source Type: research

Vessel Wall Magnetic Resonance Imaging in Acute Ischemic Stroke: Effects of Embolism and Mechanical Thrombectomy on the Arterial Wall Clinical Sciences
Conclusions— Mechanical thrombectomy results in intracranial arterial wall thickening and enhancement, potentially mimicking the VW-MRI appearance of primary arteritis. This arterial wall abnormality is less common in patients with arterial occlusion who have been treated with medical therapy alone.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Power, S., Matouk, C., Casaubon, L. K., Silver, F. L., Krings, T., Mikulis, D. J., Mandell, D. M. Tags: Embolic stroke, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Primary and Secondary Stroke Prevention Clinical Sciences Source Type: research

Finding atrial fibrillation in stroke patients: Randomized evaluation of enhanced and prolonged Holter monitoring—Find-AFRANDOMISED —rationale and design
Background: Detecting paroxysmal atrial fibrillation (AF) in patients with ischemic strokes presenting in sinus rhythm is challenging because episodes are often short, occur randomly, and are frequently asymptomatic. If AF is detected, recurrent thromboembolism can be prevented efficiently by oral anticoagulation. Numerous uncontrolled studies using various electrocardiogram (ECG) devices have established that prolonged ECG monitoring increases the yield of AF detection, but most established procedures are time-consuming and costly. The few randomized trials are mostly limited to cryptogenic strokes. The optimal method, du...
Source: American Heart Journal - July 7, 2014 Category: Cardiology Authors: Mark Weber-Krüger, Götz Gelbrich, Raoul Stahrenberg, Jan Liman, Pawel Kermer, Gerhard F. Hamann, Joachim Seegers, Klaus Gröschel, Rolf Wachter, Find-AFRANDOMISED investigators Tags: Trial Designs Source Type: research

Can a 'microwave helmet' really detect strokes?
Conclusion This study has shown that haemorrhagic strokes could potentially be distinguished from ischaemic strokes by analysing microwave scattering measurements. While the two types of stroke can already be accurately diagnosed by CT or MRI scans in hospital, the “microwave helmet” development is important because it could potentially be used before someone arrives in hospital. This would avoid any time delay and allow people with ischaemic stroke to receive the anti-clotting medication that they need as soon as possible, potentially reducing the extent of damage the stroke causes. The technique isn’t perfect ye...
Source: NHS News Feed - June 17, 2014 Category: Consumer Health News Tags: Heart/lungs Medical practice Source Type: news

Patent foramen ovale and stroke in intermediate-risk pulmonary embolism.
CONCLUSIONS: PFO and related ischemic strokes are frequent in intermediate-risk pulmonary embolism. TEE is much more efficient than TTE for PFO diagnostic. Considering the high risk of intra-cranial bleeding with thrombolysis in PE, which in part may be due to haemorrhagic transformation of sub-clinical strokes, screening PFO with TEE should be considered in intermediate risk PE when a thrombolytic treatment is discussed. PMID: 24874409 [PubMed - as supplied by publisher]
Source: Chest - May 29, 2014 Category: Respiratory Medicine Authors: Doyen D, Castellani M, Moceri P, Chiche O, Lazdunski R, Bertora D, Cerboni P, Chaussade C, Ferrari E Tags: Chest Source Type: research

In Vitro and In Vivo Evaluation of a Magnetic Resonance Imaging–guided Focused Ultrasound System for Dissolving Clots in Combination with Thrombolytic Drugs
Conclusions: The MRgFUS technique was proven successful in dissolving clots in vitro and in vivo. It was found that the volume of dissolved clot increases with acoustic intensity and beam size and decreases with frequency. With this system, it was possible to push ultrasound through a plastic phantom skull using a .5 MHz transducer. The beam of ultrasound through the phantom skull was monitored using the MRI technique of fast spoiled gradient. Finally, the thrombus in the in vivo model (ear artery) was successfully destroyed with the therapeutic protocols investigated in the in vitro models. This study shows that FUS ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 1, 2014 Category: Neurology Authors: Christakis Damianou, Venediktos Hadjisavvas, Kleanthis Ioannides Tags: Original Articles Source Type: research

RNase A in (Xeno)Transplantation
ConclusionsRNase A significantly improved graft survival. On the basis of these sweeping results, however, we suppose that RNase A could be an important adjuvant drug not only in allotransplantation but even in xenotransplantation. References[1] Fischer S, Gerriets T, Wessels C, et al. Extracellular RNA mediates endothelial‐cell permeability via vascular endothelial growth factor. Blood 2007; 110(7): 2457–2465.[2] Kannemeier C, Shibamiya A, Nakazawa F, et al. Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation. Proc Natl Acad Sci U S A 2007; 104(15): 6388–6393.[3] Fischer S, Grantzow T,...
Source: Xenotransplantation - April 19, 2014 Category: Transplant Surgery Authors: Eike Kleinert, Bruno Reichart, Tanja Mayr, Jan‐Michael Abicht, Paolo Brenner, Christian Hagl, Martin Langenmayer, Ruediger Wanke, Elisabeth Deindl, Sonja Guethoff Tags: Program and Abstracts Source Type: research

Intracranial Venous Sinus Thrombosis: Report of Three Cases (P6.255)
CONCLUSIONS: Recently, the diagnosis of Intracranial Sinus Thrombosis has increased due to rising clinical awareness especially in patients with some risk factors. Initial anticoagulation with heparin is reasonable, regardless of the presence of intracranial hemorrhage. MRI and MRV have become in important diagnostic tools.Study Supported by: No oneDisclosure: Dr. Reyes Garay has nothing to disclose. Dr. Sueldo Feijoo has nothing to disclose. Dr. Gavidia Chucan has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Reyes Garay, H., Sueldo Feijoo, C., Gavidia Chucan, J. M. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Susceptibility weighted magnetic resonance imaging of brain: A multifaceted powerful sequence that adds to understanding of acute stroke
Conclusions: SWI has been previously shown to be sensitive in detecting hemorrhage; however is not routinely used in stroke evaluation. Our study shows that SWI, by virtue of identifying unsuspected hemorrhage, central occluded vessel, and venous congestion is additive in value to the routine MR exam and should be part of a routine MR brain in patients suspected of having an acute infarct.
Source: Annals of Indian Academy of Neurology - March 12, 2014 Category: Neurology Authors: Deepti NaikSanjaya ViswamitraAshok A KumarMG Srinath Source Type: research

Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats
Our objective is to develop a new therapy for the treatment of stroke. Currently, the only effective therapy for acute ischemic stroke is the thrombolytic agent recombinant tissue plasminogen activator. α1-Antitrypsin (AAT), a serine proteinase inhibitor with potent anti-inflammatory, anti-apoptotic, antimicrobial, and cytoprotective activities, could be beneficial in stroke. The goal of this study is to test whether AAT can improve ischemic stroke outcome in an established rat model. Middle cerebral artery occlusion was induced in male rats via intracranial (i.c.) microinjection of endothelin-1. Five to 10 minutes after...
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2014 Category: Neurology Authors: Huong L. Moldthan, Aaron C. Hirko, Jeffrey S. Thinschmidt, Maria B. Grant, Zhimin Li, Joanna Peris, Yuanqing Lu, Ahmed S. Elshikha, Michael A. King, Jeffrey A. Hughes, Sihong Song Tags: Original Articles Source Type: research

Recurrent Ischemic Stroke in a Patient with the Trousseau Syndrome Treated with Dabigatran
A 70-year-old man with multiple ischemic strokes was diagnosed with cardiac embolism and treated with dabigatran. Three months later, he suddenly developed vertigo and vomiting. Magnetic resonance imaging, showed recurrent lesions and blood tests revealed hypercoagulability, hypoproteinemia, and elevated cytokeratin 19 fragments that serve as a tumor marker of lung cancer. Chest computed tomography showed there were small nodules in bilateral lungs and swollen mediastinal lymph nodes. A conclusive diagnosis was impossible because the patient declined invasive procedures. We suspected primary lung cancer and diagnosed conco...
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2014 Category: Neurology Authors: Kosuke Yoshida, Takashi Kimura, Yoko Aburakawa, Yasuhiro Suzuki, Kenji Kuroda, Osamu Yahara Tags: Case Reports Source Type: research

Cerebral Venous Thrombosis: Clinical Features, Risk Factors, and Long-term Outcome in a Tunisian Cohort
Conclusions: Our Tunisian population presented distinct risk factors profile with high frequency of thrombophilia, infections, and postpartum state. Oral contraceptive use is not a major risk factor in our population. The overall prognosis was good.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2014 Category: Neurology Authors: Youssef Sidhom, Malek Mansour, Mariem Messelmani, Hajer Derbali, Nejiba Fekih-Mrissa, Jamel Zaouali, Ridha Mrissa Tags: Original Articles Source Type: research

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