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Higher admission fasting plasma glucose levels are associated with a poorer short-term neurologic outcome in acute ischemic stroke patients with good collateral circulation
ConclusionHigher admission FPG levels are associated with significantly higher rates of unfavorable neurologic outcome of acute ischemic stroke patients with good collateral circulation. FPG and rFTD may serve as useful predictors of short-term patient outcome and could be used for risk stratification in clinical decision making.
Source: Acta Diabetologica - April 12, 2018 Category: Endocrinology Source Type: research

Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart.
In conclusion, this is the first report showing that in teleosts, Nesfatin-1 potentiates mechanical cardiac performance, strongly supporting the evolutionary importance of the peptide in the control of the cardiac function of vertebrates. PMID: 26248227 [PubMed - as supplied by publisher]
Source: General and Comparative Endocrinology - August 4, 2015 Category: Endocrinology Authors: Mazza R, Gattuso A, Filice M, Cantafio P, Cerra MC, Angelone T, Imbrogno S Tags: Gen Comp Endocrinol Source Type: research

Electrocardiographic and scintigraphic evaluation of patients with subclinical hyperthyroidism during workout
Abstract Subclinical hyperthyroidism (sHT) was found to be associated with elevated heart rate, blood pressure and increased risk of extrasystoles. However, the full clinical relevance of morphological and functional implications of sHT on the cardiovascular system is still a matter of debate. The aim of the study was to prospectively assess the influence of endogenous sHT on exercise capacity and cardiac function during workout with the use of exercise electrocardiography (ExECG) and perfusion scintigraphy. The studied group consisted of 44 consecutively recruited patients diagnosed with sHT. In all patients, ExE...
Source: Endocrine - February 9, 2016 Category: Endocrinology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

A novel potential therapy for vascular diseases: blood‐derived stem/progenitor cells specifically activated by dendritic cells
ConclusionsThese observations provide preliminary evidence that alternatively‐activated DCs can promote the generation of EPC‐enriched SPCs within a one‐day culture. The resulting product BGC101 has the potential for treatment of various vascular conditions such as coronary heart disease, stroke and peripheral ischemia. This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - March 18, 2014 Category: Endocrinology Authors: Yael Porat, Efrat Assa‐Kunik, Michael Belkin, Michael Krakovsky, Itschak Lamensdorf, Revital Duvdevani, Galit Sivak, Mark J. Niven, Shlomo Bulvik Tags: Research Article Source Type: research

Assessing endothelial dysfunction in adolescents and young adults with type 1 diabetes mellitus using a non‐invasive heat stimulus
ConclusionsAdolescents and young adults with T1D have evidence of microvascular dysfunction that can be detected using heat, a non‐invasive physiologic stimulus. HbA1c appears to play an independent role in determining microvascular perfusion suggesting tight glycemic control is probably important for the development of vascular disease.
Source: Pediatric Diabetes - August 1, 2014 Category: Endocrinology Authors: Amy S. Shah, Zhiqian Gao, Lawrence M. Dolan, Dana Dabelea, Ralph B. D'Agostino, Elaine M. Urbina Tags: Original Article Source Type: research

Assessment of myocardial metabolic flexibility and work efficiency in human Type 2 diabetes using 16-18F-fluoro-4-thiapalmitate, a novel PET fatty acid tracer.
Abstract Altered myocardial fuel selection likely underlies cardiac disease risk in diabetes, affecting oxygen demand and myocardial metabolic flexibility. We investigated myocardial fuel selection and metabolic flexibility in human Type 2 Diabetes (T2DM), using positron emission tomography to measure rates of myocardial fatty acid oxidation (16-(18)F-fluoro-4-thia-palmitate, FTP), and myocardial perfusion and total oxidation ((11)C-acetate). Participants underwent paired studies under fasting conditions, comparing 3-hour insulin+glucose euglycemic clamp conditions (120 mU/m(2)/min) to 3-hour saline infusion. Lean...
Source: Am J Physiol Endocri... - January 5, 2016 Category: Endocrinology Authors: Mather KJ, Hutchins GD, Perry K, Territo W, Chisholm R, Acton A, Glick-Wilsom B, Considine RV, Moberly S, DeGrado TR Tags: Am J Physiol Endocrinol Metab Source Type: research

Assessment of myocardial metabolic flexibility and work efficiency in human type 2 diabetes using 16-18Ffluoro-4-thiapalmitate, a novel PET fatty acid tracer
Altered myocardial fuel selection likely underlies cardiac disease risk in diabetes, affecting oxygen demand and myocardial metabolic flexibility. We investigated myocardial fuel selection and metabolic flexibility in human type 2 diabetes mellitus (T2DM), using positron emission tomography to measure rates of myocardial fatty acid oxidation {16-[18F]fluoro-4-thia-palmitate (FTP)} and myocardial perfusion and total oxidation ([11C]acetate). Participants underwent paired studies under fasting conditions, comparing 3-h insulin + glucose euglycemic clamp conditions (120 mU·m–2·min–1) to 3-h saline in...
Source: AJP: Endocrinology and Metabolism - March 15, 2016 Category: Endocrinology Authors: Mather, K. J., Hutchins, G. D., Perry, K., Territo, W., Chisholm, R., Acton, A., Glick-Wilson, B., Considine, R. V., Moberly, S., DeGrado, T. R. Tags: Articles Source Type: research

Characterisation of myocardial structure and function in adult-onset growth hormone deficiency using cardiac magnetic resonance
AbstractGrowth hormone (GH) can profoundly influence cardiac function. While GH excess causes well-defined cardiac pathology, fewer data are available regarding the more subtle cardiac changes seen in GH deficiency (GHD). This preliminary study uses cardiac magnetic resonance imaging (CMR) to assess myocardial structure and function in GHD. Ten adult-onset GHD patients underwent CMR, before and after 6 and 12 months of GH replacement. They were compared to 10 age-matched healthy controls and sex-matched healthy controls. Left ventricular (LV) mass index (LVMi) increased with 1 year of GH replacement (53.8 vs. 57.0 vs. 57.3...
Source: Endocrine - August 16, 2016 Category: Endocrinology Source Type: research

Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes
CONCLUSIONS Pioglitazone improves whole-body and myocardial insulin sensitivity, LV diastolic function, and systolic function in T2D. Improved myocardial insulin sensitivity and diastolic function are strongly correlated.
Source: Diabetes Care - October 23, 2017 Category: Endocrinology Authors: Clarke, G. D.; Solis-Herrera, C.; Molina-Wilkins, M.; Martinez, S.; Merovci, A.; Cersosimo, E.; Chilton, R. J.; Iozzo, P.; Gastaldelli, A.; Abdul-Ghani, M.; DeFronzo, R. A. Tags: Epidemiology-Diabetes Complications Pathophysiology/Complications Source Type: research

Thyroid status and brain circulation: The Rotterdam Study
CONCLUSIONS: These results suggest that thyroid dysfunction could lead to brain diseases such as stroke or dementia through a suboptimal brain circulation that is potentially modifiable.PMID:34634119 | DOI:10.1210/clinem/dgab744
Source: The Journal of Clinical Endocrinology and Metabolism - October 11, 2021 Category: Endocrinology Authors: Lana Fani Oscar Roa Due ñas Daniel Bos Meike W Vernooij Caroline C W Klaver M Kamran Ikram Robin Peeters M Arfan Ikram Layal Chaker Source Type: research