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Condition: Stroke
Therapy: Stem Cell Therapy

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Total 2351 results found since Jan 2013.

Post-stroke Impairment of the Blood –Brain Barrier and Perifocal Vasogenic Edema Is Alleviated by Endovascular Mesenchymal Stem Cell Administration: Modulation of the PKCδ/MMP9/AQP4-Mediated Pathway
AbstractPost-stroke edema and upregulation of aquaporin 4 (AQP4) water transport channels play a significant role in the progression of stroke pathology and deteriorating stroke outcomes. Prior studies from our lab have demonstrated the safety and efficacy of intra-arterial (IA) 1  × 105 mesenchymal stem cells (MSCs) administration post-stroke towards functional restoration and neuroprotection. Protein kinases have been reported to be involved in the signaling cascade of edema, with evidence supporting both its upregulation and downregulation at 24  h post-stroke. Among different protein kinase C (PKC) isoforms, the ...
Source: Molecular Neurobiology - February 21, 2022 Category: Neurology Source Type: research

A comparative study of different doses of bone marrow-derived mesenchymal stem cells improve post-stroke neurological outcomes via intravenous transplantation
CONCLUSIONS: Treatment with MSC restored the sensory and motor function of cerebral ischemia rats, indicating it may be an effective therapy for ischemic stroke.PMID:36379315 | DOI:10.1016/j.brainres.2022.148161
Source: Brain Research - November 15, 2022 Category: Neurology Authors: Yuan Chen Dingguo Peng Jingyi Li Lingling Zhang Jiacheng Chen Lin Wang Yansong Gao Source Type: research

Identification of key biomarkers in ischemic stroke: single-cell sequencing and weighted co-expression network analysis
CONCLUSIONS: Our study provides a reference for the study of pathogenesis and key targets of ischemic stroke.PMID:37418282 | DOI:10.18632/aging.204855
Source: Aging - July 7, 2023 Category: Biomedical Science Authors: Jiali Tao Xiaochen Xie Man Luo Qingsong Sun Source Type: research

A Randomized Control Trial of Granulocyte Colony Stimulating Factor (G-CSF) Intervention in Acute Ischemic Stroke to Improve Functional Outcome (P1.139)
Conclusions: Endogenous mobilization of bonemarrow hematopoietic stem cells by GCSF administration perhaps leads to better functional outcome. This study provides preliminary evidence of potential safety, feasibility, and tolerability of G-CSF therapy in patients with acute ischaemic stroke. The safety and modest efficacy demonstrated in this study augurs for further studies with a larger sample sizes and longer follow ups.Disclosure: Dr. Gorthi has nothing to disclose. Dr. Nauwhar has nothing to disclose. Dr. Gupta has nothing to disclose. Dr. Hassan has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gorthi, S., Nauwhar, D., Gupta, P., Hassan, K. Tags: Cerebrovascular Disease and Interventional Neurology: Rehabilitation and Recovery Source Type: research

Stroke serum priming modulates characteristics of mesenchymal stromal cells by controlling the expression miRNA-20a.
Abstract Transplantation of mesenchymal stem cells (MSCs), expanded with fetal bovine serum (FBS), has some limitations, including a long culture period required to obtain sufficient stem cells. Priming of MSCs with serum from patients with ischemic stroke (stroke serum) increased the proliferation rate and the neurorestorative capacity of MSCs. We hypothesized that this novel priming method increases the proliferation rate of MSCs via the regulation of microRNAs (miRs). Thus, we investigated miR profiling in stroke serum primed MSCs and tested whether the regulation of certain miRs may affect the proliferation ra...
Source: Cell Transplantation - January 13, 2016 Category: Cytology Authors: Kim EH, Kim DH, Kim HR, Kim SY, Kim HH, Bang OY Tags: Cell Transplant Source Type: research

Therapeutic effect of ligustilide-stimulated adipose-derived stem cells in a mouse thromboembolic stroke model.
Abstract Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have potential for use in rescue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide isolated from the herb Angelica sinensis exhibits a n...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Chi K, Fu RH, Huang YC, Chen SY, Lin SZ, Huang PC, Lin PC, Chang FK, Liu SP Tags: Cell Transplant Source Type: research

Breaking the blood brain barrier to aid stem cell therapeutics in the chronic stroke brain.
Abstract Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate peripherally delivered stem cells to exert the therapeutic benefits on the stroke brain. Although this BBB permeation-aided stem cell therapy has been demonstrated in the acute stage of stroke, such BBB permeation in the chronic stage of the disease remains to be examined. Adult Sprague-Dawley rats initially received sham surgery or experimental stroke via the one-hour middle cerebral artery occlusion (MCAo) model. At one month after the MCAo surgery, stroke animals were randomly assigned to receive human umbilical cord stem cells ...
Source: Cell Transplantation - February 15, 2016 Category: Cytology Authors: Tajiri N, Lee JY, Acosta S, Sanberg PR, Borlongan CV Tags: Cell Transplant Source Type: research

Cell Therapy for Stroke: Review of Previous Clinical Trials and Introduction of Our New Trials.
In this study, we introduce the preparation of a new clinical trial, the Research on Advanced Intervention using Novel Bone marrow stem cell (RAINBOW) study. The trial will start in 2016, and we hope that it will not only be helpful for treating patients but also for clarifying the therapeutic mechanisms. Moreover, we review stem cell therapeutics as an emerging paradigm in stroke (STEPS) and the guidelines for the development of cell therapy for stroke in the United States as well as introduce the development of new guidelines in Japan. These guidelines are expected to encourage the development of cell therapy for stroke ...
Source: Neurologia Medico-Chirurgica - June 17, 2016 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery
Publication date: Available online 22 November 2017 Source:Stem Cell Reports Author(s): Ayden Gouveia, Matthew Seegobin, Timal S. Kannangara, Ling He, Fredric Wondisford, Cesar H. Comin, Luciano da F. Costa, Jean-Claude Béïque, Diane C. Lagace, Baptiste Lacoste, Jing Wang Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity. Since stroke-related brain damage releases micro-environmental cues, we examined the role of a signaling-induced epigenetic pathway, an atypical protein kinase C (aPKC)-mediated phosphorylation of CREB-bindi...
Source: Stem Cell Reports - December 1, 2017 Category: Stem Cells Source Type: research

CD271+, CXCR7+, CXCR4+, and CD133+ Stem/Progenitor Cells and Clinical Characteristics of Acute Ischemic Stroke Patients
This study discovers possible activity of the CD45–CD34 + CD271+ progenitor/stem cells during the first 7 days after ischemic stroke, suggests associations of the CD45–CD34 + CD133+ cells with the neurological status of stroke patients, and some activity of the CD45–CD34 + CD133+, the CD45–CD34 + CXCR4+, and the CD45– CD34 + CXCR7+ progenitor/stem cells in the process of arterial remodeling.
Source: NeuroMolecular Medicine - May 9, 2018 Category: Neurology Source Type: research

Repetitive transcranial magnetic stimulation promotes functional recovery and differentiation of human neural stem cells in rats after ischemic stroke.
Abstract Stem cells hold great promise as a regenerative therapy for ischemic stroke by improving functional outcomes in animal models. However, there are some limitations regarding the cell transplantation, including low rate of survival and differentiation. Repetitive transcranial magnetic stimulation (rTMS) has been widely used in clinical trials as post-stroke rehabilitation in ischemic stroke and has shown to alleviate functional deficits following stroke. The present study was designed to evaluate the therapeutic effects and mechanisms of combined human neural stem cells (hNSCs) with rTMS in a middle cerebra...
Source: Experimental Neurology - December 4, 2018 Category: Neurology Authors: Peng JJ, Sha R, Li MX, Chen LT, Han XH, Guo F, Chen H, Huang XL Tags: Exp Neurol Source Type: research

Human placenta mesenchymal stem cell protection in ischemic stroke is Angiotensin converting enzyme ‐2 (ACE‐2) and masR receptor dependent
In this study we demonstrated that hPMSC-derived ACE2 is required to protect against progressive loss of cerebral blood perfusion following ischemic stroke. This effect is also mediated through vascular endothelial Mas receptor but not AT2 receptor. Consequently, the results of our experimental stroke studies with human derived stem cells describes new paracrine function of hPMSC in which ACE2 and Mas receptor are critical, therefore, providing a novel therapeutic strategy for stroke in near future.
Source: Stem Cells - June 15, 2021 Category: Stem Cells Authors: Mansoureh Barzegar, Shantel Vital, Karen Y. Stokes, Yuping Wang, J. Winny Yun, Luke A. White, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander Tags: Regenerative Medicine Source Type: research