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Specialty: Neuroscience
Condition: Pain

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Total 180 results found since Jan 2013.

Late-onset thermal hypersensitivity after focal ischemic thalamic infarcts as a model for central post-stroke pain in rats
; Cenk Ayata
Source: Journal of Cerebral Blood Flow and Metabolism - June 30, 2015 Category: Neuroscience Authors: Francesco BlasiFanny HerissonShuxing WangJianren MaoCenk Ayata Tags: central post-stroke pain endothelin-1 hyperalgesia thalamus Source Type: research

Modafinil for the Improvement of Patient Outcomes Following Traumatic Brain Injury
Conclusion. Modafinil is a central nervous system stimulant with well-established effectiveness in the treatment of narcolepsy and shift-work sleep disorder. There is conflicting evidence about the benefits of modafinil in the treatment of fatigue and EDS secondary to TBI. One randomized, controlled study states that modafinil does not significantly improve patient wakefulness, while another concludes that modafinil corrects EDS but not fatigue. An observational study provides evidence that modafinil increases alertness in fatigued patients with past medical history of brainstem diencephalic stroke or multiple sclerosis. ...
Source: Innovations in Clinical Neuroscience - April 1, 2018 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Review excessive daytime sleep fatigue head injury modafinil stroke TBI traumatic brain injury Source Type: research

P 219. Navigated repeated transcranial magnetic stimulation in stroke rehabilitation (randomized blind sham-controlled study), Preliminary results: safety and tolerability
Conclusion: Repeated nTMS is safe and effective add-method in motor post-stroke rehabilitation, but continuous study and forming protocols are necessary to validate this method.ClinicalTrials.gov Identifier: NCT01652677.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: M. Piradov, L. Chernikova, M. Tanashyan, A. Kadykov, A. Chervyakov, M. Nazarova, V. Gnezditsky, R. Konovalov, N. Savitskaya, P. Fedin, A. Suslin, M. Glebov, L. Dobrynina Tags: Society Proceedings Source Type: research

Neurosteroids: a novel promise for the treatment of stroke and post ‐stroke complications
AbstractStroke is the primary reason for death and disability worldwide, with few treatment strategies to date. Neurosteroids, which are natural molecules in the brain, have aroused great interest in the field of stroke. Neurosteroids are a kind of steroid that acts on the nervous system, and are synthesized in the mitochondria of neurons or glial cells using cholesterol or other steroidal precursors. Neurosteroids mainly include estrogen, progesterone (PROG), allopregnanolone, dehydroepiandrosterone (DHEA), and vitamin D (VD). Most of the preclinical studies have confirmed that neurosteroids can decrease the risk of strok...
Source: Journal of Neurochemistry - September 5, 2021 Category: Neuroscience Authors: Jiawei Xu, Yunxiang Zhou, Caochong Yan, Xiaoyu Wang, Jianyao Lou, Yi Luo, Shiqi Gao, Junjie Wang, Liang Wu, Xiangfu Gao, Anwen Shao Tags: REVIEW ARTICLE Source Type: research

White Matter Injury in Ischemic Stroke
Publication date: Available online 14 April 2016 Source:Progress in Neurobiology Author(s): Yuan Wang, Gang Liu, Dandan Hong, Fenghua Chen, Xunming Ji, Guodong Cao Stroke is one of the major causes of disability and mortality worldwide. It is well known that ischemic stroke can cause gray matter injury. However, stroke also elicits profound white matter injury, a risk factor for higher stroke incidence and poor neurological outcomes. The majority of damage caused by stroke is located in subcortical regions and, remarkably, white matter occupies nearly half of the average infarct volume. Indeed, white matter is exqu...
Source: Progress in Neurobiology - April 13, 2016 Category: Neuroscience Source Type: research

Muscle haematoma due to antithrombotic treatment for ischaemic stroke
Publication date: July 2015 Source:Journal of Clinical Neuroscience, Volume 22, Issue 7 Author(s): Akiyuki Hiraga , Yoko Nakagawa , Ikuo Kamitsukasa , Takeshi Suzuki , Satoshi Kuwabara The purpose of this study was to evaluate the incidence and clinical features of muscle haematoma in ischaemic stroke patients. Muscle haematomas are rare complications that occur during antithrombotic treatment for acute ischaemic stroke. Clinical and laboratory records of ischaemic stroke patients with muscle haematomas in the last 3.5years were retrospectively reviewed. Muscular haematoma developed in three of 694 (0.4%) consecutive pat...
Source: Journal of Clinical Neuroscience - May 31, 2015 Category: Neuroscience Source Type: research

Effect of mirror therapy on recovery of stroke survivors: A systematic review and network meta-analysis
Publication date: Available online 5 July 2018Source: NeuroscienceAuthor(s): Yue Yang, Qingchun Zhao, Yingshi Zhang, Qiong Wu, Xiaowen Jiang, Gang ChengAbstractMirror therapy (MT) as a relatively new rehabilitation technique has been widely applied in stroke patients. A number of randomized controlled trials (RCTs) have investigated the effects of MT for stroke survivors. The main purpose of this network meta-analysis was to investigate the effects of MT on motor function, activities of daily living (ADL), and pain perception in stroke survivors. Several databases were searched to identify RCTs evaluating the effects of MT...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research

Updates in the Treatment of Post-Stroke Pain
AbstractPurpose of ReviewTo provide an overview of the current treatment strategies for common subtypes of post-stroke pain.Recent FindingsThere is growing research interest in non-pharmacological treatment approaches for chronic pain, including neurostimulation as well as lifestyle and psychosocial interventions. Newer pharmacotherapy research includes cannabinoids and NMDA-receptor antagonists as well as bee venom. Persistent post-stroke headache is an increasingly appreciated entity, though the role of novel chronic migraine treatments for post-stroke headache is not known.SummaryOverall, most treatment approaches to po...
Source: Current Neurology and Neuroscience Reports - November 12, 2019 Category: Neuroscience Source Type: research

Successful deep brain stimulation for central post-stroke pain and dystonia in a single operation
Conclusions Deep brain stimulation targeting multiple brain networks in one operation is feasible and safe. Deep brain stimulation may be considered in some refractory cases of central post-stroke pain; however, it requires meticulous programming.
Source: Journal of Clinical Neuroscience - March 16, 2018 Category: Neuroscience Source Type: research

S1-1. Spinal cord stimulation for post-stroke pain
Spinal cord stimulation (SCS) is used to treat for several types of intractable pain syndromes, but it is not commonly used for treating post-stroke pain. Therefore, in this study, we analyzed the effects of SCS in patients with post-stroke pain. Neurological imaging and pharmacological analysis using thiopental, ketamine and morphine tests were conducted for 30 patients with post-stroke pain. For all patients, percutaneous electrodes were inserted under local anesthesia, and trial stimulation was performed for 5–7days. If the patient experienced pain relief during the trial stimulation, a pulse generator was implanted. ...
Source: Clinical Neurophysiology - July 16, 2013 Category: Neuroscience Authors: Toshiki Obuchi, Mitsuru Watanabe, Koichiro Sumi, Toshikazu Kano, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Atsuo Yoshino, Takamitsu Yamamoto, Yoichi Katayama Tags: Society Proceedings Source Type: research

The Relationship Between Herpes Zoster and Stroke
Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1–2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large ep...
Source: Current Neurology and Neuroscience Reports - February 25, 2015 Category: Neuroscience Source Type: research

P 168. TMS neurophysiology and interventional rTMS in children with perinatal stroke: Safety and tolerability in the PLASTIC CHAMPS trial
Introduction/Question: Perinatal stroke causes hemiplegic cerebral palsy and lifelong disability. TMS can define neurophysiology and central therapeutic targets while rTMS carries therapeutic potential in adult stroke but have not been applied to the more plastic developing brain. Ipsilateral projections from the unlesioned hemisphere to the affected hand are prominent in this population and the effects of non-lesioned inhibitory rTMS are unknown.Methods: PLASTIC CHAMPS is a randomized, blinded, factorial clinical trial of rTMS and constraint therapy (CIMT) to enhance upper extremity function in children (6–18years) with...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: T. Rajapakse, O. Kirton, J. Roe, A. Kirton Tags: Society Proceedings Source Type: research