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Condition: Pain
Drug: Gabapentin

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Total 24 results found since Jan 2013.

Pharmacological Management of Central Post-Stroke Pain: A Practical Guide
Abstract Pain is one of the most troublesome sequelae of stroke. Some of this post-stroke pain is caused by the brain lesion itself; this is called central post-stroke pain (CPSP). Although the prevalence of CPSP is low (1–8 %), persistent, often treatment-resistant, painful sensations are a major problem for stroke patients. The pathogenesis of CPSP remains unknown, but suggested underlying causes include hyperexcitation in the damaged sensory pathways, damage to the central inhibitory pathways, or a combination of the two. For pharmacological treatment, amitriptyline, an adrenergic antidepressant, is current...
Source: CNS Drugs - September 1, 2014 Category: Neurology Source Type: research

Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin
In this study, we first determined the relationship between the lesion site and changes in mechanical or thermal pain sensitivity in a rat CPSP model with experimental thalamic hemorrhage produced by unilateral intra-thalamic collagenase IV (ITC) injection. Then, we evaluated the efficacy of gabapentin (GBP), an anticonvulsant that binds the voltage-gated Ca2+ channel α2δ and a commonly used anti-neuropathic pain medication. Histological case-by-case analysis showed that only lesions confined to the medial lemniscus and the ventroposterior lateral/medial nuclei of the thalamus and/or the posterior thalamic nucleus result...
Source: Neuroscience Bulletin - November 5, 2014 Category: Neuroscience Source Type: research

A Medication Combination for the Treatment of Central Post-Stroke Pain (CPSP) via the Adjuvant use of Prednisone with Gabapentin: A Case Report
Publication date: Available online 25 September 2015 Source:PM&R Author(s): Luis Batlle, Ryan Mattie, Robert Irwin Case Description CPSP is a neuropathic pain syndrome that can occur from pathology of the brain. The case presented is of a female with multiple comorbidities and who was found to have an acute infarct in the left middle and anterior cerebral artery territories. She began to complain of worsening diffuse right upper and lower extremity pain, and central post-stroke pain was diagnosed. First-line agents were contraindicated due to medical comorbidities, and chronic kidney disease only permitted the...
Source: PMandR - September 26, 2015 Category: Rehabilitation Source Type: research

CO85 Association of Gabapentin Use with Functional Limitations Among Stroke Survivors: A Multi-Institutional Electronic Health Records Database Analysis
This study determines the effect of gabapentin on functional recovery measures such as mobility and GAIT abnormality among stroke survivors.
Source: Value in Health - June 1, 2023 Category: International Medicine & Public Health Authors: M. Pathak, R. Neba, B. Zhou, R. Rasu, U. Sambamoorthi Source Type: research

Although pharmacological treatment may have beneficial effects in central post-stroke pain, it does not abolish the symptoms
Abstract The management of central post-stroke pain is challenging. Amitriptyline is considered the first-line pharmacological choice, with lamotrigine, gabapentin and pregabalin used as alternative therapies. If the therapeutic response with monotherapy is insufficient, combination therapy (e.g. an adrenergic antidepressant plus an antiepileptic) may be considered.
Source: Drugs and Therapy Perspectives - February 4, 2015 Category: Drugs & Pharmacology Source Type: research

A Medication Combination for the Treatment of Central Post-Stroke Pain (CPSP) via the Adjuvant use of Prednisone with Gabapentin: A Case Report
CPSP is a neuropathic pain syndrome that can occur from pathology of the brain. The case presented is of a female with multiple comorbidities and who was found to have an acute infarct in the left middle and anterior cerebral artery territories. She began to complain of worsening diffuse right upper and lower extremity pain, and central post-stroke pain was diagnosed. First-line agents were contraindicated due to medical comorbidities, and chronic kidney disease only permitted the use of low dose gabapentin.
Source: PM and R - September 23, 2015 Category: Rehabilitation Authors: Luis Batlle, Ryan Mattie, Robert Irwin Source Type: research

Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of the α 2 δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity
Abstract The α2δ-1 subunit of the voltage-gated Ca2+ channel (VGCC) is a molecular target of gabapentin (GBP), which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive effects by disrupting trafficking of the α2δ-1 subunit to the presynaptic membrane, resulting in decreased neurotransmitter release. We previously showed that GBP has an anti-allodynic effect in the first two weeks; but this is followed by insensitivity in the later stage after repeated administration in a rat model of central post-stroke pain (CPSP) hypersensitivity induced by intra-thalamic h...
Source: Neuroscience Bulletin - January 19, 2016 Category: Neuroscience Source Type: research

Restless Limbs Syndrome (RLS) Presenting as Hemisyndrome: A Case of Dejerine-Roussy Syndrome Responsive to Dopamine Agonists (P5.266)
CONCLUSION: Recognition of RLS as a hemisyndrome may offer new treatments for patients with chronic dysesthetic pain, paresthesia, and insomnia as illustrated in this case of DRS. RLS affects 10% of the population and DRS is seen in 10% after thalamic stroke. Pain associated with RLS may be contributing to chronic, persistent pain in patients with certain CNS lesions and may be treatable with Dopamine Agonists.Disclosure: Dr. Dickoff has received personal compensation for activities with UCB Pharma and Teva pharmaceuticals as a speaker.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dickoff, D. Tags: Movement Disorders: Sleep and Movement Disorders and Miscellaneous Diagnoses Source Type: research

A Rare Case of Painful Trigeminal Neuropathy Secondary to Lateral Medullary Infarct: Neuroimaging and Electrophysiological Studies.
CONCLUSION: Painful trigeminal neuropathy attributed to lateral medullary infarct is a unique disease entity. Ophthalmic branch involvement, coexisting sensory deficits, absence of triggers, and rapid evolvement and remission are its characteristics. Our neuroimaging study delineated ischemic stroke pathology within descending tract and spinal nucleus of trigeminal nerve. Serial electrophysiological studies provide evidences supporting ephaptic transmission as the main pathogenesis concordant with dynamics of neuropathic pain and therapeutic implications. PMID: 26179839 [PubMed - in process]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research

Effects of Adjuvant Analgesics on Cerebral Ischemia-Induced Mechanical Allodynia.
Abstract Central post-stroke pain (CPSP), a potential sequela of stroke, is classified as neuropathic pain. Although we recently established a CPSP-like model in mice, the effects of adjuvant analgesics as therapeutic drugs for neuropathic pain in this model are unknown. Hence, the aim of the present study was to assess the usefulness of our model by evaluating the effects of adjuvant analgesics used for treating neuropathic pain in this mouse model of CPSP. Male ddY mice were subjected to 30 min of bilateral carotid artery occlusion (BCAO). The development of hind paw mechanical allodynia was measured after BCA...
Source: Biological and Pharmaceutical Bulletin - May 8, 2016 Category: Drugs & Pharmacology Authors: Matsuura W, Harada S, Tokuyama S Tags: Biol Pharm Bull Source Type: research

The neurology of itch
Research over the past 15 years has helped to clarify the anatomy and physiology of itch, the clinical features of neuropathic itch syndromes and the scientific underpinning of effective treatments. Two itch-sensitive pathways exist: a histamine-stimulated pathway that uses mechanically insensitive C-fibres, and a cowhage-stimulated pathway primarily involving polymodal C-fibres. Interactions with pain continue to be central to explaining various aspects of itch. Certain spinal interneurons (Bhlhb5) inhibit itch pathways within the dorsal horn; they may represent mediators between noxious and pruritic pathways, and allow s...
Source: Brain - February 5, 2014 Category: Neurology Authors: Dhand, A., Aminoff, M. J. Tags: Review Article Source Type: research

Multimodal analgesia versus traditional opiate based analgesia after cardiac surgery, a randomized controlled trial
Background: To evaluate if an opiate sparing multimodal regimen of dexamethasone, gabapentin, ibuprofen and paracetamol had better analgesic effect, less side effects and was safe compared to a traditional morphine and paracetamol regimen after cardiac surgery. Methods: Open-label, prospective randomized controlled trial. 180 patients undergoing cardiac procedures through median sternotomy, were included in the period march 2007- August 2009. 151 patients were available for analysis. Pain was assessed with the 11-numeric rating scale (11-NRS). Results: Patients in the multimodal group demonstrated significantly lower avera...
Source: Journal of Cardiothoracic Surgery - March 20, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Sulman RafiqDaniel SteinbrüchelMichael WanscherLars AndersenAlbert NavneNikolaj LilleoerPeter Olsen Source Type: research

Top medicine articles for April 2014
A collection of some interesting medical articles published recently:A Big Bet on Gluten-Free: 11% of households reporting purchases of gluten-free foods in 2013 (doubled in 3 yrs). 30% of the public says it would like to cut back on the amount of gluten it’s eating. "There is a growing population of people who have somehow heard that gluten-free is healthier or think of it as fashionable, and when they remove gluten from their diet, they’re inadvertently taking out a lot of processed foods and are really feeling the benefits of eating healthier foods.” http://buff.ly/1mt9phmNew nomenclature and classifications are p...
Source: Clinical Cases and Images - April 23, 2014 Category: Journals (General) Tags: Health News of the Day Source Type: news

Demographics, Comorbidities and Clinical Features in Hospitalized Patients with Myoclonus (P3.022)
CONCLUSIONS: Myoclonus was particularly associated with renal impairment in the presence of a toxic exposure, most commonly opioids or anticonvulsants, and unlike patients with anoxia or hepatic impairment, more often featured a negative semiology.Disclosure: Dr. Ehrlich has nothing to disclose. Dr. Swan has nothing to disclose. Dr. Robbins has received personal compensation for activities with MedLink and Prova Education. Dr. Robbins has received personal compensation in an editorial capacity for Current Pain and Headache Reports. Dr. Herskovitz has nothing to disclose. Dr. Milstein has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Ehrlich, D., Swan, M., Robbins, M., Herskovitz, S., Milstein, M. Tags: Movement Disorders: Myoclonus, Paroxysmal Dyskinesias, and Parkinson ' s Disease Source Type: research

Ice Pick Headache
Abstract Ice pick headache, also called idiopathic or primary stabbing headache, is a unique headache type associated with ultra-brief stabs of pain, most commonly in the frontal or temporal area. It occurs predominantly in women and is estimated to affect 2–35 % of the population. Unlike other headache types of short duration, such as short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT), ice pick headache is not associated with any cranial autonomic symptoms but has been known to occur with nausea, vomiting, photophobia, and dizziness. It exists in two forms: primary ...
Source: Current Pain and Headache Reports - April 1, 2016 Category: Neurology Source Type: research