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Condition: Multiple Sclerosis
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Total 888 results found since Jan 2013.

Reliability and validity of Six-Spot Step Test (SSST) in stroke survivors
CONCLUSIONS: The SSST was a reliable test and showed a significant correlation with FMA-LE scores, BBS scores, and TUG test times in stroke survivors.CLINICAL REHABILITATION IMPACT: The SSST can be used to assess the advanced balance control of stroke survivors.PMID:34128605 | DOI:10.23736/S1973-9087.21.06799-X
Source: European Journal of Physical and Rehabilitation Medicine - June 15, 2021 Category: Rehabilitation Authors: Tai Wa Liu Shamay S Ng Ka-Yuen Cheung Ming-Yeung Cheung Ryan N Hung Man-Fai Lam Adrian T Wong Cynthia Y Lai Mimi M Tse Source Type: research

Natalizumab: a new therapy for acute ischemic stroke?
This article reviews the main experimental studies on the blockage of CD49d and identifies the potential underlying causes for their inconclusive results. Despite these divergences and the difficulties in translation of experimental studies, a phase II clinical trial has recently been conducted to evaluate the efficacy of Natalizumab in stroke patients (ACTION trial). Preliminary results of the trial are also discussed here, together with a general overview of the emerged importance of the neuroprotective strategies based on the mitigation of post-stroke neuroinflammation. Expert commentary: Despite Natalizumab showing pos...
Source: Expert Review of Neurotherapeutics - August 2, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Dextromethorphan/Quinidine for Pseudobulbar Affect Following Stroke: Safety and Effectiveness in the PRISM II Trial
ConclusionsDM/Q effectively treated PBA and was associated with global and functional improvement; adverse events were consistent with the known safety profile of DM/Q.
Source: PMandR - July 5, 2018 Category: Rehabilitation Source Type: research

Affective Disorder and Functional Status as well as Selected Sociodemographic Characteristics in Patients with Multiple Sclerosis, Parkinson's Disease and History of Stroke.
Conclusions: Although depression and anxiety are highly prevalent in patients with neurological conditions, the disorder has a very individual nature and is not associated with the patient's age, duration of a condition or concomitant diseases. Screening for depression and anxiety as a part of comprehensive approach may increase treatment efficacy in neurological patients. PMID: 32156038 [PubMed - in process]
Source: Medicina (Kaunas) - March 6, 2020 Category: Universities & Medical Training Authors: Knapik A, Krzystanek E, Szefler-Derela J, Siuda J, Rottermund J, Plinta R, Brzęk A Tags: Medicina (Kaunas) Source Type: research

Translation into Brazilian Portuguese, cross-cultural adaptation, reliability and validation of the Functional Ambulation Classification for the categorization of ambulation following a stroke in a clinical setting.
CONCLUSION: The translation, cross-cultural adaptation and measurement properties demonstrated that the FAC is a valid, reliable clinical measure for the categorization of ambulation in the Brazilian population of stroke survivors in a clinical setting. PMID: 32390129 [PubMed - in process]
Source: Revista de Neurologia - May 13, 2020 Category: Neurology Authors: Elord C, Corrêa FI, Pereira GS, Silva SM, Corrêa JC Tags: Rev Neurol Source Type: research

Do gait parameters improve after botulinum toxin injections in post stroke patients? A prospective study
In conclusion the use of botulinum toxin injections is beneficial in post stroke patients as this is depicted in gait parameters change which accompanies the spasticity reduction.PMID:34384786 | DOI:10.1016/j.toxicon.2021.08.001
Source: Toxicon - August 13, 2021 Category: Toxicology Authors: Dimitrios N Varvarousis Dimitris Dimopoulos George I Vasileiadis Ioannis Manolis Avraam Ploumis Source Type: research

Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion
AbstractRepulsive guidance molecule A (RGMa) is an inhibitor of neuronal growth and survival which is upregulated in the damaged central nervous system following acute spinal cord injury (SCI), traumatic brain injury, acute ischemic stroke (AIS), and other neuropathological conditions. Neutralization of RGMa is neuroprotective and promotes neuroplasticity in several preclinical models of neurodegeneration and injury including multiple sclerosis, AIS, and SCI. Given the limitations of current treatments for AIS due to narrow time windows to intervention (TTI), and restrictive patient selection criteria, there is significant...
Source: Translational Stroke Research - June 16, 2023 Category: Neurology Source Type: research

Glatiramer acetate does not protect from acute ischemic stroke in mice
Conclusions: Glatiramer acetate failed to protect from acute ischemic stroke in our hands. Further studies are needed to assess the true therapeutic potential of glatiramer acetate and related immunomodulators in brain ischemia.
Source: BioMed Central - February 27, 2014 Category: Journals (General) Authors: Peter KraftKerstin GöbelSven G MeuthChristoph Kleinschnitz Source Type: research

Efficacy of exercise intervention programs on cognition in people suffering from multiple sclerosis, stroke and Parkinson's disease: A systematic review and meta-analysis of current evidence.
CONCLUSION: Due to lack of commonality between measures of cognition, training sequences and intervention period, it remains unclear as to whether exercise training can be effective in improving the cognitive functions of neurological patients. PMID: 26484519 [PubMed - in process]
Source: NeuroRehabilitation - January 25, 2016 Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research

Assessing and treating pain associated with stroke, multiple sclerosis, cerebral palsy, spinal cord injury and spasticity. Evidence and recommendations from the Italian Consensus conference on Pain in Neurorehabilitation.
ian Consensus Conference on Pain in Neurorehabilitation (ICCPN) Abstract Pain is a common and disabling symptom in patients with stroke, multiple sclerosis (MS), cerebral palsy (CP), spinal cord injury (SCI) and other conditions associated with spasticity, but data on its prevalence, and natural history, as well as guidelines on its assessment and treatment in the field of neurorehabilitation, are largely lacking. The Italian Consensus Conference on Pain in Neurorehabilitation (ICCPN) searched and evaluated current evidence on the frequency, evolution, predictors, assessment, and pharmacological and non-pharmacolo...
Source: European Journal of Physical and Rehabilitation Medicine - August 30, 2016 Category: Rehabilitation Authors: Paolucci S, Martinuzzi A, Scivoletto G, Smania N, Solaro C, Aprile I, Armando M, Bergamaschi R, Berra E, Berto G, Carraro E, Cella M, Gandolfi M, Masciullo M, Molinari M, Pagliano E, Pecchioli C, Roncari L, Torre M, Trabucco E, Vallies G, Zerbinati P, Ita Tags: Eur J Phys Rehabil Med Source Type: research

Improvement During Inpatient Rehabilitation Among Older Adults With Guillain-Barré Syndrome, Multiple Sclerosis, Parkinson Disease, and Stroke
Conclusions Patients with Guillain-Barré syndrome, multiple sclerosis, Parkinson disease, and stroke should improve during inpatient rehabilitation but anticipated outcomes for patients with Guillain-Barré syndrome should be even higher.
Source: American Journal of Physical Medicine and Rehabilitation - November 17, 2018 Category: Rehabilitation Tags: Original Research Articles Source Type: research

Mobility Disorders in Stroke, Parkinson Disease, and Multiple Sclerosis: A Multicenter Cross-Sectional Study
Objective The aims of the study were to compare mobility in multiple sclerosis, Parkinson disease, and stroke, and to quantify the relationship between mobility and participation restrictions. Design This is a multicenter cross-sectional study. Included were compliant subjects with Parkinson disease, multiple sclerosis, and stroke seen for rehabilitation, with no comorbidities interfering with mobility. Functional scales were applied to each subject to investigate gait speed (10-meter walking test), balance while maintaining body position (Berg Balance Scale), dynamic balance and mobility (Timed Up and Go and Dynamic ...
Source: American Journal of Physical Medicine and Rehabilitation - December 19, 2019 Category: Rehabilitation Tags: Original Research Articles Source Type: research