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Condition: Hypertension
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Countries: Japan Health
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Total 171 results found since Jan 2013.
Vascular endothelial growth factor receptor 1 gene ( < em > FLT1 < /em > ) longevity variant increases lifespan by reducing mortality risk posed by hypertension
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues.PMID:37178326 | DOI:10.18632/aging.204722
Source: Aging - May 13, 2023 Category: Biomedical Science Authors: Brian J Morris Randi Chen Timothy A Donlon Kalpana J Kallianpur Kamal H Masaki Bradley J Willcox Source Type: research
Roche and Alnylam report positive topline results from Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi therapeutic in development to treat hypertension in patients at high risk of cardiovascular disease
Zilebesiran met primary endpoint demonstrating greater than 15 mmHg reduction of systolic blood pressure at three months of treatment compared to placeboStudy met key secondary endpoints showing consistent and sustained reductions of systolic blood pressure at six monthsZilebesiran demonstrated an encouraging safety and tolerability profile in adult patients with mild-to-moderate hypertensionFull study results to be presented at an upcoming scientific conferenceBasel, 7 September 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) and Alnylam announced today that the Phase 2 study KARDIA-1 of zilebesiran, an investigational RNAi the...
Source: Roche Media News - September 7, 2023 Category: Pharmaceuticals Source Type: news
Dietary acid load and mortality among Japanese men and women: the Japan Public Health Center-based Prospective Study.
Conclusion: A high dietary acid load score was associated with a higher risk of total mortality and mortality from CVD, particularly from IHD, in Japanese adults.
PMID: 28539378 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 24, 2017 Category: Nutrition Authors: Akter S, Nanri A, Mizoue T, Noda M, Sawada N, Sasazuki S, Tsugane S, Japan Public Health Center–based Prospective Study Group Tags: Am J Clin Nutr Source Type: research
Dietary intake habits and prevalence of nocturia in Japanese patients with type 2 diabetes mellitus
ConclusionsWe found the inverse association between vegetable intake habit and nocturia in Japanese patients with type 2 diabetes mellitus.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - May 1, 2017 Category: Endocrinology Authors: Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake Tags: Original Article Source Type: research
Dietary acid load and mortality among Japanese men and women: the Japan Public Health Center-based Prospective Study Nutritional epidemiology and public health
Conclusion: A high dietary acid load score was associated with a higher risk of total mortality and mortality from CVD, particularly from IHD, in Japanese adults.
Source: American Journal of Clinical Nutrition - July 3, 2017 Category: Nutrition Authors: Akter, S., Nanri, A., Mizoue, T., Noda, M., Sawada, N., Sasazuki, S., Tsugane, S., the Japan Public Health Center-based Prospective Study Group Tags: Diabetes Nutritional epidemiology and public health Source Type: research
Dietary intake habits and the prevalence of nocturia in Japanese patients with type 2 diabetes mellitus
ConclusionsWe found an inverse association between vegetable intake habit and nocturia in Japanese patients with type 2 diabetes mellitus.
No data regarding the association between dietary intake and nocturia is available among patients with type 2 diabetes mellitus. This study is the first to show a significant inverse association between dietary vegetable intake and nocturia and severe nocturia among Japanese patients with type 2 diabetes mellitus.
Source: Journal of Diabetes Investigation - August 14, 2017 Category: Endocrinology Authors: Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Hiroaki Miyaoka, Teruki Miyake, Shin Yamamoto, Koutatsu Maruyama, Keiko Tanaka, Teruhisa Ueda, Hidenori Senba, Masamoto Torisu, Hisaka Minami, Takeshi Tanigawa, Bunzo Matsuura, Yoichi Hiasa, Yoshihiro Miyake Tags: Original Article Source Type: research
Heterogeneity in 14-year Dementia Incidence Between Asian American Subgroups
Conclusions: Future studies are needed to understand how immigration history, social, environmental, and genetic factors contribute to dementia risk in the growing and diverse Asian American population.
Source: Alzheimer Disease and Associated Disorders - July 1, 2017 Category: Geriatrics Tags: Original Articles Source Type: research
Medtronic readies pivotal trial in renal denervation
Medtronic (NYSE:MDT) said today that it’s ready for a run at FDA approval for renal denervation in treating high blood pressure, more than three years after the failure of a high-profile clinical trial.
Back in January 2014, Fridley, Minn.-based Medtronic shocked medtech when it announced that the highly anticipated Symplicity HTN-3 trial, examining ablation of the around the renal arteries in treating hypertension, failed to meet its efficacy endpoint. The company suspended enrollment in its other Symplicity trials around the world and later took a $200 million write-down on its renal denervation assets. News of th...
Source: Mass Device - August 28, 2017 Category: Medical Devices Authors: Brad Perriello Tags: Cardiovascular Clinical Trials Wall Street Beat Medtronic Renal Source Type: news
Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions:
We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527
Received: 17 May 2016
Revised: 04 May 2017
Accepted: 09 May 2017
Published: 18 September 2017
Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research
Abstract P146: Uric Acid is an Independent Risk Factor for Developing Hypertension From Prehypertension: A 5-year Japanese Cohort Study Session Title: Onsite Poster Competition I With Reception
This study is conducted to clarify the risks.Methods: We conducted a retrospective 5-year cohort study using the data from 3,584 prehypertensive Japanese adults (52.1±11.0 years, 2,081 men) in 2004 and reevaluated it 5 years later. We calculated the cumulative incidences of hypertension over 5 years, then, we detected the risk factors and calculated odds ratios (ORs) for developing hypertension by crude analysis and after adjustments for age, sex, body mass index, smoking and drinking habits, baseline systolic and diastolic blood pressure, pulse rate, diabetes mellitus, dyslipidemia, chronic kidney disease, and serum uric...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Masanari Kuwabara, Shigeko Hara, Koichiro Niwa, Minoru Ohno, Ichiro Hisatome Tags: Poster Abstract Presentations Source Type: research
Uric Acid Is a Strong Risk Marker for Developing Hypertension From PrehypertensionNovelty and Significance Hyperuricemia and Prehypertension
Prehypertension frequently progresses to hypertension, a condition associated with high morbidity and mortality from cardiovascular diseases and stroke. However, the risk factors for developing hypertension from prehypertension remain poorly understood. We conducted a retrospective cohort study using the data from 3584 prehypertensive Japanese adults (52.1±11.0 years, 2081 men) found to be prehypertensive in 2004 and reexamined in 2009. We calculated the cumulative incidences of hypertension over 5 years, examined risk factors, and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, bo...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Masanari Kuwabara, Ichiro Hisatome, Koichiro Niwa, Shigeko Hara, Carlos A. Roncal-Jimenez, Petter Bjornstad, Takahiko Nakagawa, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Gabriela Garcia, Bernardo Rodriguez-Iturbe, Minoru Ohno, Miguel A. Lanaspa, Rich Tags: Cardiovascular Disease, Epidemiology, Risk Factors, High Blood Pressure, Hypertension Original Articles Source Type: research
Day-by-Day Variability of Home Blood Pressure and Incident Cardiovascular Disease in Clinical PracticeNovelty and Significance Blood Pressure Variability
We assessed the relationship between day-by-day home blood pressure (BP) variability and incident cardiovascular disease (CVD) in clinical practice. J-HOP study (Japan Morning Surge-Home Blood Pressure) participants underwent home BP monitoring in the morning and evening for a 14-day period, and their BP levels and BP variability independent of the mean (VIM) were assessed. Incident CVD events included coronary heart disease and stroke. Cox models were fitted to assess the home BP variability–CVD risk association. Among 4231 participants (mean±SD age, 64.9±10.9 years; 53.3% women; 79.1% taking antihypertensive medicati...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Satoshi Hoshide, Yuichiro Yano, Hiroyuki Mizuno, Hiroshi Kanegae, Kazuomi Kario Tags: Hypertension Original Articles Source Type: research
Carotid atherosclerosis and the association between nocturnal blood pressure dipping and cardiovascular events
The impact of a nondipping blood pressure (BP) pattern, defined as (awake systolic BP – sleep systolic BP)/awake systolic BP < 0.1, on cardiovascular events in populations with different degrees of carotid atherosclerosis is uncertain. The authors hypothesized that a nondipping BP pattern would show differential predictive power for cardiovascular events, including total cardiovascular death, sudden death, nonfatal cardiovascular events, and nonfatal stroke, between populations with and without carotid atherosclerosis. To test this hypothesis, the authors analyzed 493 patients (mean age 67.9 years, 47.5% men) from ...
Source: The Journal of Clinical Hypertension - February 16, 2018 Category: Cardiology Authors: Praew Kotruchin, Satoshi Hoshide, Kazuomi Kario Tags: ORIGINAL PAPER Source Type: research
Vegetable Protein Intake was Inversely Associated with Cardiovascular Mortality in A 15-Year Follow-Up Study of A General Japanese Population.
CONCLUSIONS: Vegetable protein intake may prevent future CVD, particularly in nonhypertensive subjects in the Japanese population. However, further studies are necessary to examine the biological mechanisms of this effect.
PMID: 30089755 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - August 10, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
