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Specialty: Cytology
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Total 135 results found since Jan 2013.

PI3K –AKT Pathway Protects Cardiomyocytes Against Hypoxia-Induced Apoptosis by MitoKATP-Mediated Mitochondrial Translocation of pAKT
Conclusion: These findings suggest that the anti-apoptotic effect of the PI3K-AKT pathway through pAKT translocation to mitochondrial via mitoKATP may be conducted through modification of CcO activity.Cell Physiol Biochem 2018;49:717 –727
Source: Cellular Physiology and Biochemistry - September 2, 2018 Category: Cytology Source Type: research

Calcineurin/NFAT Signaling Modulates Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Apoptosis in Monocrotaline-Induced Pulmonary Arterial Hypertension Rats
Conclusion: Our results demonstrate that CaN/NFAT signaling is activated and involved in the modulation of PASMC proliferation, migration and apoptosis in MCT-induced PAH.Cell Physiol Biochem 2018;49:172 –189
Source: Cellular Physiology and Biochemistry - August 22, 2018 Category: Cytology Source Type: research

RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes.
Abstract Cardiac ischemia/reperfusion, loss of blood flow and its subsequent restoration, causes damage to the heart. Oxidative stress from ischemia/reperfusion leads to dysfunction and death of cardiomyocytes, increasing the risk of progression to heart failure. Alterations in mitochondrial dynamics, in particular mitochondrial fission, have been suggested to play a role in cardioprotection from oxidative stress. We tested the hypothesis that activation of RhoA regulates mitochondrial fission in cardiomyocytes. Our studies show that expression of constitutively active RhoA in cardiomyocytes increases phosphorylat...
Source: Cellular Signalling - June 25, 2018 Category: Cytology Authors: Brand CS, Tan VP, Brown JH, Miyamoto S Tags: Cell Signal Source Type: research

A2BAR activation attenuates acute lung injury by inhibiting alveolar epithelial cell apoptosis both in vivo and in vitro.
In conclusion, A2BAR activation effectively attenuated OA-induced ALI by inhibiting AEC apoptosis and mitigated H2O2-induced AEC injury by suppressing the p38 and ERK1/2-mediated mitochondrial apoptosis pathway. PMID: 29898376 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - June 13, 2018 Category: Cytology Authors: Xu X, Zhu Q, Niu F, Zhang R, Wang Y, Wang W, Sun D, Wang X, Wang A Tags: Am J Physiol Cell Physiol Source Type: research

β-catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3-L1 adipocytes.
Abstract GLUT4 is unique among specialized glucose transporters in being exclusively expressed in muscle and adipocytes. In the absence of insulin the distribution of GLUT4 is preferentially intracellular and insulin stimulation results in the movement of GLUT4 containing vesicles to the plasma membrane. This process is responsible for the insulin stimulation of glucose uptake in muscle and fat. While signaling pathways triggering the translocation of GLUT4 are well understood, the mechanisms regulating the intracellular retention of GLUT4 are less well understood. Here we report a role for β-catenin in this proc...
Source: Experimental Cell Research - March 11, 2018 Category: Cytology Authors: Dissanayake WC, Sorrenson B, Cognard E, Hughes WE, Shepherd PR Tags: Exp Cell Res Source Type: research

Targeting of cathepsin C induces autophagic dysregulation that directs ER stress mediated cellular cytotoxicity in colorectal cancer cells.
Abstract As Autophagy is a pivotal mechanism of cancer cell survival and the development of chemotherapeutic resistance; therefore, new approaches are warranted for its targeting which may be fulfilled by cathepsins regulation. Amongst cathepsins, cathepsin C (CTSC) is highly expressed in various cancers and possesses significant therapeutic potential in autoimmune disorders; however, its role in colorectal cancer has not been explored. Herein, we aimed to investigate the role of CTSC in autophagy regulation mediated colorectal carcinoma cell proliferation. Cathepsin C targeting through inhibitors/siRNA leads to t...
Source: Cellular Signalling - March 1, 2018 Category: Cytology Authors: Khaket TP, Singh MP, Khan I, Bhardwaj M, Kang SC Tags: Cell Signal Source Type: research

Mdia1 is Crucial for Advanced Glycation End Product-Induced Endothelial Hyperpermeability
Conclusion: Our study revealed that mDia1 plays a critical role in AGE-induced microvascular hyperpermeability through binding to RAGE.Cell Physiol Biochem 2018;45:1717 –1730
Source: Cellular Physiology and Biochemistry - February 28, 2018 Category: Cytology Source Type: research

Mechano-growth factor protects against mechanical overload induced damage and promotes migration of growth plate chondrocytes through RhoA/YAP pathway.
In conclusion, MGF is an autocrine growth factor which is regulated by mechanical stimuli. MGF could not only protect growth plate chondrocytes against damage by mechanical overload, but also promote migration through activation of RhoA/YAP signaling axis. Most importantly, our findings indicate that MGF promote cell migration through YAP mediated FA formation to determine the FA-cytoskeleton remodeling. PMID: 29470961 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - February 19, 2018 Category: Cytology Authors: Jing X, Ye Y, Bao Y, Zhang J, Huang J, Wang R, Guo J, Guo F Tags: Exp Cell Res Source Type: research

YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways
Conclusion: Collectively, our results demonstrate that Hippo-Yap can serve as a tumor promoter in human rectal cancer and acts by restricting JNK/Drp1/mitochondrial fission/ HtrA2/Omi, with potential implications for new approaches to human rectal cancer therapy.Cell Physiol Biochem 2017;44:2073 –2089
Source: Cellular Physiology and Biochemistry - December 14, 2017 Category: Cytology Source Type: research

FGF ‐2 promotes osteocyte differentiation through increased E11/podoplanin expression
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 7, 2017 Category: Cytology Authors: Ekele Ikpegbu, Lena Basta, Dylan N. Clements, Robert Fleming, Tonia L. Vincent, David J. Buttle, Andrew A. Pitsillides, Katherine A. Staines, Colin Farquharson Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

Knockdown of CAVEOLIN-1 Sensitizes Human Basal-Like Triple-Negative Breast Cancer Cells to Radiation
Conclusion: Our results support the hypothesis that CAV-1 knockdown by siRNA causes increased radiosensitivity in basal-like TNBC cells. The mechanisms associated with this effect are reduced DNA repair through delayed CAV-1-associated EGFR nuclear accumulation and induction ofG2/M arrest and apoptosis through the combined effects of CAV-1 siRNA and radiation.Cell Physiol Biochem 2017;44:778 –791
Source: Cellular Physiology and Biochemistry - November 23, 2017 Category: Cytology Source Type: research

Caspase-Independent Pathway is Related to Nilotinib Cytotoxicity in Cultured Cardiomyocytes
Conclusion: Our findings demonstrate that nilotinib increases autophagy and cathepsin B activity, leading to mitochondrial AIF release and nuclear translocation, which is responsible for p53 and apoptosis induction in H9C2 cells.Cell Physiol Biochem 2017;42:2182 –2193
Source: Cellular Physiology and Biochemistry - August 16, 2017 Category: Cytology Source Type: research

Statin Regulated ERK5 Stimulates Tight Junction Formation and Reduces Permeability in Human Cardiac Endothelial Cells
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - June 22, 2017 Category: Cytology Authors: Emma L. Wilkinson, James E. Sidaway, Michael J. Cross Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

1,25-Dihydroxyvitamin D < sub > 3 < /sub > Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4
Conclusion: 1,25D3 causes ectodomain shedding of TLR4 and thereby decreases the responsiveness of cells to LPS. ADAM10, activated by extracellular Ca2+ influx, was implicated in the ectodomain cleavage of TLR4.Cell Physiol Biochem 2017;41:2104 –2116
Source: Cellular Physiology and Biochemistry - April 20, 2017 Category: Cytology Source Type: research

TET1 promotes cisplatin-resistance via demethylating the vimentin promoter in ovarian cancer.
Abstract The development of chemo-resistance impairs the outcome of the first line platinum-based chemotherapies for ovarian cancer. Deregulation of DNA methylation/demethylation provides a critical mechanism for the occurrence of chemo-resistance. The ten-eleven translocation (TET) family of dioxygenases including TET1/2/3 plays an important part in DNA demethylation, but their roles in cisplatin resistance have not been elucidated. Using cisplatin-sensitive and cisplatin-resistant ovarian cancer cell models, we found that TET1 was significantly upregulated in cisplatin-resistant CP70 cells compared with that in ...
Source: Cell Biology International - February 1, 2017 Category: Cytology Authors: Han X, Zhou Y, You Y, Lu J, Wang L, Hou H, Li J, Chen W, Zhao L, Li X Tags: Cell Biol Int Source Type: research