Caspase-Independent Pathway is Related to Nilotinib Cytotoxicity in Cultured Cardiomyocytes

Conclusion: Our findings demonstrate that nilotinib increases autophagy and cathepsin B activity, leading to mitochondrial AIF release and nuclear translocation, which is responsible for p53 and apoptosis induction in H9C2 cells.Cell Physiol Biochem 2017;42:2182 –2193
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research