1,25-Dihydroxyvitamin D < sub > 3 < /sub > Attenuates the Effects of Lipopolysaccharide by Causing ADAM10-Dependent Ectodomain Shedding of Toll-Like Receptor 4

Conclusion: 1,25D3 causes ectodomain shedding of TLR4 and thereby decreases the responsiveness of cells to LPS. ADAM10, activated by extracellular Ca2+ influx, was implicated in the ectodomain cleavage of TLR4.Cell Physiol Biochem 2017;41:2104 –2116
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research