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Beneficial Effect of Edoxaban on Preventing Atrial Fibrillation and Coagulation by Reducing Inflammation via HBG1/HBD Biomarkers
Conclusion: Edoxaban could prevent atrial fibrillation and coagulation by reducing inflammation, lipids, and fibrosis via HBG1/HBD biomarkers effectively, and the effect was superior to that of rivaroxaban.
Source: Frontiers in Pharmacology - June 3, 2022 Category: Drugs & Pharmacology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

LIM kinase 1 acts as a profibrotic mediator in permanent atrial fibrillation patients with valvular heart disease.
Abstract Atrial fibrillation (AF) is the most frequently diagnosed cardiac arrhythmia worldwide. Patients with permanent atrial fibrillation are at an increased risk of developing valvular heart disease. Atrial fibrosis occurs in this pathophysiological setting. LIM kinase 1 (LIMK1) is a serine/threonine kinase that regulates microtubule stability and actin polymerization in fibroblasts. LIMK1 has been implicated in the pathogenesis of atrial fibrillation. Clinical data and biopsies of the right atrial appendage were collected from 50 patients with valvular heart disease who underwent heart valve replacement surge...
Source: Journal of Biosciences - February 28, 2019 Category: Biomedical Science Authors: Chen Q, Gimple RC, Li G, Chen J, Wu H, Li R, Xie J, Xu B Tags: J Biosci Source Type: research

Downregulation of Long Non-Coding RNA Kcnq1ot1: An Important Mechanism of Arsenic Trioxide-Induced Long QT Syndrome
Conclusions: To our knowledge, this report is the first to demonstrate that lncRNAKcnq1ot1 downregulation is responsible for QT interval prolongation induced by ATO at least partially by repressingKcnq1 expression. lncRNAKcnq1ot1 has important pathophysiological functions in the heart and could become a novel antiarrhythmic target.Cell Physiol Biochem 2018;45:192 –202
Source: Cellular Physiology and Biochemistry - January 16, 2018 Category: Cytology Source Type: research

Current state of the art for cardiac arrhythmia gene therapy
Publication date: Available online 19 June 2017 Source:Pharmacology & Therapeutics Author(s): J. Kevin Donahue Cardiac arrhythmias are a leading cause of morbidity and mortality. Currently available therapeutic options lack sufficient efficacy and safety. Gene therapy has been proposed for treatment of cardiac arrhythmias. This review will discuss the current state of development for arrhythmia gene therapy. So far, all published studies are short-term, proof-of-concept animal studies. Potential replacement of cardiac pacemakers has been shown for combination gene therapy using the HCN2 gene and either the gene fo...
Source: Pharmacology and Therapeutics - June 20, 2017 Category: Drugs & Pharmacology Source Type: research

Deletion of Kvβ1.1 subunit leads to electrical and hemodynamic changes causing cardiac hypertrophy in female murine hearts
This article is protected by copyright. All rights reserved
Source: Experimental Physiology - January 1, 2016 Category: Physiology Authors: Jared Tur, Kalyan C. Chapalamadugu, Timothy Padawer, Sachin L. Badole, Peter J. Kilfoil II, Aruni Bhatnagar, Srinivas M. Tipparaju Tags: Research Paper Source Type: research

NOS1AP modulates intracellular Ca(2+) in cardiac myocytes and is up-regulated in dystrophic cardiomyopathy.
Authors: Treuer AV, Gonzalez DR Abstract NOS1AP gene (nitric oxide synthase 1-adaptor protein) is strongly associated with abnormalities in the QT interval of the electrocardiogram and with sudden cardiac death. To determine the role of NOS1AP in the physiology of the cardiac myocyte, we assessed the impact of silencing NOS1AP, using siRNA, on [Ca(2+)]i transients in neonatal cardiomyocytes. In addition, we examined the co-localization of NOS1AP with cardiac ion channels, and finally, evaluated the expression of NOS1AP in a mouse model of dystrophic cardiomyopathy. Using siRNA, NOS1AP levels were reduced to ~30% of...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - November 16, 2014 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor
The objective of this study was to investigate the major determinant for the cell death induced by matrine in human hepatocellular carcinoma. We use human hepatocellular carcinoma cell line HepG2 and human hepatocellular carcinoma xenograft in nude mice as models to study the action of matrine in hepatocellular cancers. We found that caspase-dependent and -independent Program Cell Death (PCD) occurred in matrine-treated HepG2 cells, accompanied by the decreasing of mitochondrial transmembrane potential and the increasing ROS production. Further studies showed that AIF released from the mitochondria to the nucleus, and sile...
Source: Molecular Cancer - March 16, 2014 Category: Cancer & Oncology Authors: Huan ZhouMinying XuYa GaoZhigang DengHanwei CaoWenqing ZhangQiao WangBing ZhangGang SongYanyan ZhanTianhui Hu Source Type: research