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Condition: Hemorrhagic Stroke
Procedure: Transplants

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Total 200 results found since Jan 2013.

Impact of Stroke Onset Severity on 2-Year Survival in Destination Therapy Patients Supported by Centrifugal Flow versus Axial Flow Ventricular Assist Devices
The ENDURANCE Supplemental Trial (DT2) was designed to prospectively study whether improved blood pressure management would reduce the incidence of strokes in destination therapy patients receiving an HVAD. The trial not only demonstrated a significant reduction in hemorrhagic strokes, but also some reductions in stroke-related severity. This analysis seeks to study further the impact of stroke severity on 2-year survival in both the HVAD and control cohorts of DT2.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: P. Shah, C. Mahr, J. Rogers, M. Kiernan, S. Boyce, N.A. Mokadam, F. Pagani, T. Vassiliades, J. Teuteberg Tags: 145 Source Type: research

Understanding Risk Factors for Stroke Subtypes in the ENDURANCE Trials
Stroke is one of the most devastating morbidities associated with left ventricular assist device (LVAD) support. Improved blood pressure management in LVAD patients has been shown to significantly reduce strokes, in particular hemorrhagic strokes. However, little is known regarding clinical risk factors for stroke subtypes.
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: S. Cho, R. Starling, J. Teuteberg, J. Rogers, F. Pagani, P. Shah, K. Uchino, T. Vassiliades Tags: 142 Source Type: research

Risk factors of diffuse alveolar hemorrhage after acute ischemic stroke treated with tissue-type plasminogen activator. The effectiveness of activated recombinant factor VII treatment.
Conclusion: The inclusion/exclusion criteria of tPA were based on the AHA/ASA Guidelines for the early management of patients with AIS.These patients had no evidence of infections, bronchoscopy, autoimmune diseases, HIV, and transplantations. Our study suggests that systemic administration of rFVIIa for DAH is effective. Emphysema may be a risk factor for the development of DAH following tPA. When we use tPA for emphysema patients, we must be careful about DAH enough. PMID: 32547816 [PubMed]
Source: Surgical Neurology International - June 19, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage Basic Sciences
Conclusions— Intraventricular transplantation of umbilical cord blood-derived mesenchymal stem cells significantly attenuated the posthemorrhagic hydrocephalus and brain injury after IVH. This neuroprotective mechanism appears to be mediated by the anti-inflammatory effects of these cells.
Source: Stroke - January 18, 2013 Category: Neurology Authors: Ahn, S. Y., Chang, Y. S., Sung, D. K., Sung, S. I., Yoo, H. S., Lee, J. H., Oh, W. I., Park, W. S. Tags: Animal models of human disease, Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Basic Sciences Source Type: research

Endoglin Deficiency in Bone Marrow is Sufficient to Cause Cerebrovascular Dysplasia in the Adult Mouse After Vascular Endothelial Growth Factor Stimulation Brief Reports
Conclusions— Endoglin-deficient BMDCs are sufficient for VEGF to induce vascular dysplasia in the adult mouse brain. Our data support a previously unrecognized role of BM in the development of cerebrovascular malformations.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Choi, E.-J., Walker, E. J., Degos, V., Jun, K., Kuo, R., Pile-Spellman, J., Su, H., Young, W. L. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Genetically altered mice, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Aneurysm, AVM, hematoma Brief Reports Source Type: research

Mechanical embolectomy for ischemic stroke in a pediatric ventricular assist device patient
We describe a nine‐yr‐old patient on BiVAD support who experienced threatened AIS on two separate occasions. He was treated successfully via mechanical embolectomy on both occasions and survived to transplantation with minimal neurologic deficits.
Source: Pediatric Transplantation - March 20, 2014 Category: Transplant Surgery Authors: Eileen Rhee, Robert Hurst, Bryan Pukenas, Rebecca Ichord, Anne Marie Cahill, Joseph Rossano, Stephanie Fuller, Kimberly Lin Tags: Case Report Source Type: research

CHA2DS2-Vasc and HAS-BLED Scores as Predictors of Ischemic and Hemorrhagic Stroke Risk After Left Ventricular Assist Device Implantation
CHA2DS2-VASc score predicts thromboembolic event risk and HAS-BLED score predicts major bleeding risk in patients on anticoagulation with atrial fibrillation. We aimed to evaluate if these scoring systems would be predictive of ischemic stroke and intracranial bleeding complications following continuous-flow left ventricular assist device (CF-LVAD) implantation.
Source: The Journal of Heart and Lung Transplantation - April 1, 2015 Category: Transplant Surgery Authors: H.S. Kemal, S. Ertugay, S. Nalbantgil, M. Zoghi, C. Engin, T. Yagdi, M. Ozbaran Source Type: research

Risk Factors, Mortality and Timing of Ischemic and Hemorrhagic Stroke with Left Ventricular Assist Devices
Stroke is a major cause of mortality following left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Risk factors, mortality, and timing of ischemic and hemorrhagic stroke with left ventricular assist devices
Stroke is a major cause of mortality after left ventricular assist device (LVAD) placement.
Source: The Journal of Heart and Lung Transplantation - December 22, 2016 Category: Transplant Surgery Authors: Jennifer A. Frontera, Randall Starling, Sung-Min Cho, Amy S. Nowacki, Ken Uchino, M. Shazam Hussain, Maria Mountis, Nader Moazami Tags: Original Clinical Science Source Type: research

Ischemic Stroke and Intracranial Hemorrhages During Impella Cardiac Support
Impella is a percutaneously placed, ventricular assist device for short-term cardiac support. We aimed to study acute neurologic complications during short-term cardiac support with Impella. We reviewed prospectively collected data of 79 consecutive persons implanted with Impella at a single tertiary center. Acute neurologic events (ANE) were defined as ischemic strokes or intracranial hemorrhages. Among those with ANE, specific causes of ischemic and hemorrhagic events were collected and discussed. Of 79 persons with Impella with median 8 days of support (range 1–33 days), six (7.5%) developed ANE at a median of 5 days ...
Source: ASAIO Journal - July 30, 2020 Category: Medical Devices Tags: Case Report Source Type: research

Computed tomography perfusion in patients of stroke with left ventricular assist device
AbstractLeft ventricular assist devices (LVAD) are widely applied for patients with severe heart failure as a bridge to heart transplantation as well as destination therapy. Patients with implanted LVAD have an increased risk of cerebral thrombosis and computed tomographic perfusion (CTP) has the potential to be performed for early diagnosis and treatment of acute ischemic stroke (AIS), including interventional thrombectomy. Here, we report our series of CTP examination in patients having suspected AIS after LVAD implantation. We retrospectively investigated 33 contrast-enhanced CTPs from January 2017 to December 2018 whic...
Source: Heart and Vessels - August 9, 2020 Category: Cardiology Source Type: research

Association of Gut Microbiome with Early Brain Injury After Subarachnoid Hemorrhage: an Experimental Study
AbstractThe occurrence of early brain injury (EBI) following subarachnoid hemorrhage (SAH) is crucial in the prognosis of SAH; however, no effective treatment for EBI has been developed. Gut microbiome (GM) composition influences the outcome of various diseases, including ischemic stroke. Here, we evaluated whether prior GM alteration could prevent EBI following SAH. We altered the GM of 7-week-old male rats by administering antibiotic-containing water for 2  weeks and performing fecal microbiome transplantation after antibiotic induction. Composition of the GM was profiled using 16S rRNA. We induced SAH by injecting bloo...
Source: Translational Stroke Research - December 9, 2022 Category: Neurology Source Type: research

The NG2-glia is a potential target to maintain the integrity of neurovascular unit after acute ischemic stroke
Neurobiol Dis. 2023 Mar 13:106076. doi: 10.1016/j.nbd.2023.106076. Online ahead of print.ABSTRACTThe neurovascular unit (NVU) plays a critical role in health and disease. In the current review, we discuss the critical role of a class of neural/glial antigen 2 (NG2)-expressing glial cells (NG2-glia) in regulating NVU after acute ischemic stroke (AIS). We first introduce the role of NG2-glia in the formation of NVU during development as well as aging-induced damage to NVU and accompanying NG2-glia change. We then discuss the reciprocal interactions between NG2-glia and the other component cells of NVU, emphasizing the factor...
Source: Neurobiology of Disease - March 15, 2023 Category: Neurology Authors: Xiaoyan Hu Panpan Geng Xiaoyun Zhao Qian Wang Changqing Liu Chun Guo Wen Dong Xinchun Jin Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research