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Condition: Ischemic Stroke
Procedure: Perfusion

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Total 2383 results found since Jan 2013.

Machine learning-based approach reveals essential features for simplified TSPO PET quantification in ischemic stroke patients
CONCLUSION: Reliable TSPO PET quantification is achievable by using a single late PET frame divided by a late blood sample activity concentration.PMID:36682921 | DOI:10.1016/j.zemedi.2022.11.008
Source: Zeitschrift fur Medizinische Physik - January 22, 2023 Category: Radiology Authors: Artem Zatcepin Anna Kopczak Adrien Holzgreve Sandra Hein Andreas Schindler Marco Duering Lena Kaiser Simon Lindner Martin Schidlowski Peter Bartenstein Nathalie Albert Matthias Brendel Sibylle I Ziegler Source Type: research

Implications of Post-recanalization Perfusion Deficit After Acute Ischemic Stroke: a Scoping Review of Clinical and Preclinical Imaging Studies
AbstractThe goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood flow through recanalization of the occluded vessel. Unfortunately, successful recanalization does not always result in favorable clinical outcome. Post-recanalization perfusion deficits (PRPDs), constituted by cerebral hypo- or hyperperfusion, may contribute to lagging patient recovery rates, but its clinical significance remains unclear. This scoping review provides an overview of clinical and preclinical findings on post-ischemic reperfusion, aiming to elucidate the pattern and consequences of PRPD from a translational pe...
Source: Translational Stroke Research - January 19, 2023 Category: Neurology Source Type: research

Extended Multimodal Flat Detector CT Imaging in Acute Ischemic Stroke: A Pilot Study
AbstractBy using Flat detector computed tomography (FD-CT), a one-stop-shop approach in the diagnostic workup of acute ischemic stroke (AIS) might be achieved. Although information on upstream vessels is warranted, dedicated FD-CT protocols which include the imaging of the cervical vasculature are still lacking. We aimed to prospectively evaluate the implementation of a new multimodal FD-CT protocol including cervical vessel imaging in AIS patients. In total, 16 patients were included in this study. Eight patients with AIS due to large vessel occlusion (LVO) prospectively received a fully multimodal FD-CT imaging, includin...
Source: Journal of Digital Imaging - January 17, 2023 Category: Radiology Source Type: research

Sex differences in endovascular thrombectomy outcomes in large vessel occlusion: a propensity-matched analysis from the SELECT study
Conclusion In a propensity-matched cohort from the SELECT study, women had similar discharge outcomes as men following EVT, but the improvement from discharge to 90 days was significantly worse in women, suggesting the influence of post-discharge factors. Further exploration of this phenomenon to identify target interventions is warranted. Trial registration number NCT02446587.
Source: Journal of NeuroInterventional Surgery - January 11, 2023 Category: Neurosurgery Authors: Fifi, J. T., Nguyen, T. N., Song, S., Sharrief, A., Pujara, D. K., Shaker, F., Fournier, L. E., Jones, E. M., Lechtenberg, C. G., Slavin, S. J., Ifejika, N. L., Diaz, M. V., Martin-Schild, S., Schaafsma, J., Tsai, J. P., Alexandrov, A. W., Tjoumakaris, S. Tags: Editor''s choice, Ischemic stroke Source Type: research

Falsely normal CT perfusion ischemic core readings are common and often associated with deep infarcts
Conclusions CTP may completely fail to detect ischemic core in as many as 25% of cases, especially in isolated deep MCA strokes. Technical refinements of the post-processing algorithms are therefore warranted. TMC infarcts may have a lower risk of reperfusion hemorrhage, potentially due to greater preservation of the neurovascular unit structure in face of delayed recovery of cerebral blood flow.
Source: Journal of NeuroInterventional Surgery - January 11, 2023 Category: Neurosurgery Authors: Bouslama, M., Ravindran, K., Rodrigues, G. M., Pisani, L., Haussen, D. C., Frankel, M. R., Nogueira, R. G. Tags: Neuroimaging Source Type: research

Association of baseline core volume and early midline shift in acute stroke patients with a large ischaemic core
ConclusionIn patients with an acute LIC following EVT, a pretreatment infarct core volume > 40 ml based on an rCBF < 15% showed good predictive value for early MLS occurrence.
Source: Frontiers in Neurology - January 9, 2023 Category: Neurology Source Type: research

Large mismatch profile predicts rapidly progressing brain edema in acute anterior circulation large vessel occlusion patients undergoing endovascular thrombectomy
ConclusionIn patients with anterior circulation LVO stroke undergoing successful EVT, a large mismatch ratio at baseline is a protective factor for RPBE, which is associated with poor outcomes.
Source: Frontiers in Neurology - January 4, 2023 Category: Neurology Source Type: research

Invasive Neuromonitoring in the Stroke Patient
With advances in technology, the options to manage patients with neurologic injuries are often complex. Critical care management of neurologic injury has historically focused on the prevention of secondary ischemic injury through aggressive management of intracranial pressure (ICP) and maintenance of adequate cerebral perfusion pressure (CPP). However, ICP monitoring alone does not identify ischemic changes that herald patient deterioration. Advocates of multimodality monitoring cite the value of early detection of changes in brain oxygenation levels and brain metabolism as advantageous in optimizing stroke outcomes. ICP m...
Source: Critical Care Nursing Clinics of North America - January 2, 2023 Category: Nursing Authors: Carey Heck Source Type: research

CT vascular territory mapping: a novel method to identify large vessel occlusion collateral
ConclusionIn the presence of occlusion, VTM demonstrated a  reciprocal increase in collateral vessel territories.
Source: Neuroradiology - January 1, 2023 Category: Radiology Source Type: research

Visual suppression of vestibulo-ocular reflex in patients treated with carotid artery revascularization: A potential biomarker for cerebral perfusion
Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are common treatments for ischemic stroke prevention in patients with carotid artery stenosis. However, the beneficial effects of CEA/CAS for cerebral hypoperfusion due to carotid artery stenosis have yet to be fully established. As dizziness is a common symptom in patients with carotid artery stenosis, we aimed to evaluate the effects of CEA/CAS on cerebral function in patients with carotid artery stenosis, using equilibrium function tests.
Source: Journal of the Neurological Sciences - December 25, 2022 Category: Neurology Authors: Shigeta Miyake, Koji Takahashi, Yasunobu Nakai, Yu Amano, Ryoo Yamamoto, Kazumitsu Amari, Hiroya Hara, Ken Johkura Source Type: research

Modelling the Long-Term Health Outcome and Costs of Thrombectomy in Treating Stroke Patients with Large Ischaemic Core: Comparison between Clinical Trials and Real-World Data
Conclusions: Our results highlight the potential gaps when implementing an effective intervention in the real world and the importance of the rigorous selection of large infarct core patients for EVT.Cerebrovasc Dis
Source: Cerebrovascular Diseases - December 14, 2022 Category: Neurology Source Type: research

Circadian rhythm of ischaemic core progression in human stroke
Discussion These results suggest that human infarct progression varies across the 24-hour cycle with potential implications for the design and interpretation of neuroprotection trials.
Source: Journal of Neurology, Neurosurgery and Psychiatry - December 14, 2022 Category: Neurosurgery Authors: Reidler, P., Brehm, A., Sporns, P. B., Burbano, V. G., Stueckelschweiger, L., Broocks, G., Liebig, T., Psychogios, M.-N., Ricke, J., Dimitriadis, K., Dichgans, M., Kunz, W. G., Tiedt, S. Tags: Editor's choice Cerebrovascular disease Source Type: research

Economic evaluation of intravenous alteplase for stroke with the time of onset between 4.5 and 9 hours
Conclusion For patients with AIS with a time of onset between 4.5 and 9 hours, perfusion imaging-guided intravenous alteplase was likely to be cost-effective in China and was cost-effective in the US when compared with placebo.
Source: Journal of NeuroInterventional Surgery - December 14, 2022 Category: Neurosurgery Authors: Chen, J., Liang, X., Tong, X., Han, M., Ji, L., Zhao, S., Hu, Z., Liu, A. Tags: Open access, Socioeconomics Source Type: research

Agreement between estimated computed tomography perfusion ischemic core and follow-up infarct on diffusion-weighted imaging
ConclusionsIn patients with successful reperfusion after EVT, CTP-estimated ischemic core showed moderate volumetric and spatial agreement with the follow-up infarct lesion on DWI, similar to the most used commercially available CTP software packages. Severe ischemic core overestimation was relatively uncommon.
Source: Insights into Imaging - December 13, 2022 Category: Radiology Source Type: research

Imaging mismatch between Alberta Stroke Program Early CT Score and perfusion imaging may be a good variable for endovascular treatment
ConclusionsPatients with imaging mismatch treated within 24 h could benefit from EVT and without increasing the risk of sICH.Key Points•Patients with imaging mismatch between ASPECTS and ischemic core could achieve good outcomes after endovascular treatment.•Compared with large ischemic core, patients with imaging mismatch presented lower risk of symptomatic hemorrhage within 6 h and higher proportion of good outcomes within 6 –24 h.•Baseline NIHSS score, ASPECTS, ischemic core, and symptomatic intracranial hemorrhage were associated with good outcomes.
Source: European Radiology - December 11, 2022 Category: Radiology Source Type: research