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Substance P Reduces Infarct Size and Mortality After Ischemic Stroke, Possibly Through the M2 Polarization of Microglia/Macrophages and Neuroprotection in the Ischemic Rat Brain
Cell Mol Neurobiol. 2022 Sep 16. doi: 10.1007/s10571-022-01284-7. Online ahead of print.ABSTRACTSubstance-P (SP) is an 11 amino acid neuropeptide that is known to stimulate the peripheral mobilization of bone marrow mesenchymal stem cells and M2 polarization in monocytes/macrophages in a variety of acute and chronic tissue injuries. To examine the role of SP in protection and recovery from acute ischemic brain injury, experimental ischemic stroke was induced by transient middle cerebral artery occlusion (tMCAo) in rats for 1 h with subsequent reperfusion. Two injections of SP, immediately and one day post-tMCAo, resulted i...
Source: Cellular and Molecular Neurobiology - September 16, 2022 Category: Cytology Authors: Woosung Ahn Guangfan Chi Sumin Kim Youngsook Son Mingzi Zhang Source Type: research

Endovascular retrieval of bullet fragment from the basilar artery terminus
We present our technique and discuss endovascular options for management of intracranial arterial embolization of bullet fragments.
Source: Journal of NeuroInterventional Surgery - September 14, 2022 Category: Neurosurgery Authors: Ahmed, S. U., Kelly, M. E., Peeling, L. Tags: Ischemic stroke Source Type: research

Unraveling the potential of endothelial progenitor cells as a treatment following ischemic stroke
Ischemic stroke is becoming one of the most common causes of death and disability in developed countries. Since current therapeutic options are quite limited, focused on acute reperfusion therapies that are hampered by a very narrow therapeutic time window, it is essential to discover novel treatments that not only stop the progression of the ischemic cascade during the acute phase, but also improve the recovery of stroke patients during the sub-acute or chronic phase. In this regard, several studies have shown that endothelial progenitor cells (EPCs) can repair damaged vessels as well as generate new ones following cerebr...
Source: Frontiers in Neurology - September 8, 2022 Category: Neurology Source Type: research

Endogenous Neural Stem Cell-induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
Transl Stroke Res. 2022 Sep 3. doi: 10.1007/s12975-022-01078-5. Online ahead of print.ABSTRACTIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments i...
Source: Cell Research - September 3, 2022 Category: Cytology Authors: Hailiang Tang Yao Li Weijun Tang Jianhong Zhu Graham C Parker John H Zhang Source Type: research

Endogenous Neural Stem Cell –induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
AbstractIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments include transplantation of exogenous stem cells but also stimulating endogenous neural ...
Source: Translational Stroke Research - September 3, 2022 Category: Neurology Source Type: research

Outcomes of upper access with surgical exposure of the axillary artery in fenestrated and branched endovascular aneurysm repair
CONCLUSIONS: Upper access with surgical exposure of the axillary artery is a safe method for antegrade catheterization of fenestrations and branches in complex endovascular aneurysm repair.PMID:35963515 | DOI:10.1016/j.ejvs.2022.07.052
Source: PubMed: Eur J Vasc Endovasc ... - August 13, 2022 Category: Surgery Authors: Pablo Marques de Marino Maike Hagen Athanasios Katsargyris Balazs Botos Eric L Verhoeven Source Type: research

Renal cyst mimicking hydronephrosis after uterine artery ligation for postpartum haemorrhage
Conclusion: Renal cyst is a differential diagnosis of hydronephrosis. Delayed availability of the final result of medical investigations jeopardises patients ’ safety. A preliminary imaging report is prone to error and its use to determine the indication for an invasive procedure should be limited to emergencies.Keywords: Uterine artery ligation; preliminary imaging report; ureteric injury.
Source: African Health Sciences - August 1, 2022 Category: African Health Authors: Nnabuike Chibuoke Ngene Source Type: research

E-124 Timing surgery and hemorrhagic complications in endocarditis with concomitant cerebral complications
ConclusionsPatients with radiographic evidence of ischemic stroke from septic emboli can safely undergo valvular surgery for IE without increased risk of symptomatic hemorrhage. We advocate for baseline CTA screening to evaluate for IIA in patients who present with a primary diagnosis of IE and propose a management algorithm.Disclosures B. Lucke-Wold: None.
Source: Journal of NeuroInterventional Surgery - July 23, 2022 Category: Neurosurgery Authors: Lucke-Wold, B. Tags: SNIS 19th annual meeting electronic poster abstracts Source Type: research

Zinc improves neurological recovery by promoting angiogenesis via the astrocyte-mediated HIF-1 α/VEGF signaling pathway in experimental stroke
CONCLUSIONS: Zinc significantly improves neurological function recovery during the cerebral ischemia repair stage, providing new evidence supporting zinc as a potential therapeutic target for ischemic stroke by promoting astrocyte induced angiogenesis.PMID:35855611 | DOI:10.1111/cns.13918
Source: CNS Neuroscience and Therapeutics - July 20, 2022 Category: Neuroscience Authors: Yang Li Tingting Ma Xiaoyu Zhu Mingqi Zhang Liang Zhao Peng Wang Jia Liang Source Type: research

An Update on the Potential Application of Herbal Medicine in Promoting Angiogenesis
Angiogenesis, the formation of new capillaries from pre-existing vascular networks, plays an important role in many physiological and pathological processes. The use of pro-angiogenic agents has been proposed as an attractive approach for promoting wound healing and treating vascular insufficiency-related problems, such as ischemic heart disease and stroke, which are the leading causes of death worldwide. Traditional herbal medicine has a long history; however, there is still a need for more in-depth studies and evidence-based confirmation from controlled and validated trials. Many in vitro and in vivo studies have reporte...
Source: Frontiers in Pharmacology - July 19, 2022 Category: Drugs & Pharmacology Source Type: research

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