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Condition: Ischemic Stroke
Therapy: Hyperbaric Oxygen Therapy

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Total 146 results found since Jan 2013.

Improvement of memory impairments in poststroke patients by hyperbaric oxygen therapy.
Objective: Several recent studies have shown that hyperbaric oxygen (HBO₂) therapy carry cognitive and motor therapeutic effects for patients with acquired brain injuries. The goal of this study was to address the specific effects of HBO₂ on memory impairments after stroke at late chronic stages. Method: A retrospective analysis was conducted on data of 91 stroke patients 18 years or older (mean age ∼60 years) who had either ischemic or hemorrhagic stroke 3–180 months before HBO₂ therapy (M = 30–35 months). The HBO₂ protocol included 40 to 60 daily sessions, 5 days per week, 90 min each, 100% oxygen at 2ATA, ...
Source: Neuropsychology - November 10, 2014 Category: Neurology Authors: Boussi-Gross, Rahav; Golan, Haim; Volkov, Olga; Bechor, Yair; Hoofien, Dan; Schnaider Beeri, Michal; Ben-Jacob, Eshel; Efrati, Shai Source Type: research

Hyperbaric Oxygen Therapy in Acute Ischemic Stroke: A Review
Stroke, also known as cerebrovascular disease, is a common and serious neurological disease, which is also the fourth leading cause of death in the United States so far. Hyperbaric medicine, as an emerging interdisciplinary subject, has been applied in the treatment of cerebral vascular diseases since the 1960s. Now it is widely used to treat a variety of clinical disorders, especially hypoxia-induced disorders. However, owing to the complex mechanisms of hyperbaric oxygen (HBO) treatment, the therapeutic time window and the undefined dose as well as some common clinical side effects (such as middle ear barotrauma), the wi...
Source: Interventional Neurology - November 7, 2014 Category: Neurology Source Type: research

Hyperbaric oxygen for neurologic indications. Action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy and status migrainosus
Publication date: September–October 2012 Source:Pediatria Polska, Volume 87, Issue 5 Author(s): Harry T. Whelan , Ann K. Helms Introduction: There is great interest in using hyperbaric oxygen (HBO) to treat neurological disease. The exquisite sensitivity of neural tissue to hypoxia makes increased oxygenation attractive as a therapy for disease processes that induce ischemia, edema, and, more recently, apoptosis. Four things specifically exist as targets for future projects and clinical trials: (1) stroke (2) traumatic brain injury (3) radiation induced necrosis and (4) status migrainosus. Methods: Specific aims: Strok...
Source: Pediatria Polska - November 6, 2014 Category: Pediatrics Source Type: research

Combination of HBO and Memantine in Focal Cerebral Ischemia: Is There a Synergistic Effect?
In this study, we investigated whether or not MEM could prolong the narrow therapeutic window of HBO treatment. Transient focal cerebral ischemia was induced in male Sprague–Dawley rats by middle cerebral artery occlusion (MCAO) for 120 min. MCAO produced neurobehavioral deficits, increased infarction volume, increased Evans blue (EB) content and levels of pro-inflammatory factors, as well as depleted glutathione (GSH), and reduced catalase (CAT) and superoxide dismutase (SOD) activity in the ischemic ipsilateral hemisphere. The combination of 5 mg/kg MEM treatment 15 min after the onset of ischemic event and HBO ther...
Source: Molecular Neurobiology - October 30, 2014 Category: Neurology Source Type: research

Hyperbaric oxygen treatment in the experimental spinal cord injury model
Spinal cord trauma is a major cause of mortality and morbidity. Although no known treatment for spinal cord injury exists, a limited number of effective treatment modalities and procedures are available that improve secondary injury. Hyperbaric oxygen (HBO) treatment has been used to assist in neurologic recovery after cranial injury or ischemic stroke.
Source: The Spine Journal - February 13, 2014 Category: Orthopaedics Authors: Onur Yaman, Banu Yaman, Figen Aydın, Ahmet Var, Cüneyt Temiz Source Type: research

Proton therapy for reirradiation of progressive or recurrent chordoma.
CONCLUSIONS: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional toxicities may develop with longer follow-up times. PMID: 24267972 [PubMed - in process]
Source: Health Physics - November 28, 2013 Category: Physics Authors: McDonald MW, Linton OR, Shah MV Tags: Int J Radiat Oncol Biol Phys Source Type: research

Proton Therapy for Reirradiation of Progressive or Recurrent Chordoma
Conclusions: Full-dose proton reirradiation provided encouraging initial disease control and overall survival for patients with recurrent or progressive chordoma, although additional toxicities may develop with longer follow-up times.
Source: International Journal of Radiation Oncology * Biology * Physics - November 23, 2013 Category: Radiology Authors: Mark W. McDonald, Okechuckwu R. Linton, Mitesh V. Shah Tags: Central Nervous System Tumors Source Type: research

The medical use of oxygen: a time for critical reappraisal
Abstract Oxygen treatment has been a cornerstone of acute medical care for numerous pathological states. Initially, this was supported by the assumed need to avoid hypoxaemia and tissue hypoxia. Most acute treatment algorithms, therefore, recommended the liberal use of a high fraction of inspired oxygen, often without first confirming the presence of a hypoxic insult. However, recent physiological research has underlined the vasoconstrictor effects of hyperoxia on normal vasculature and, consequently, the risk of significant blood flow reduction to the at‐risk tissue. Positive effects may be claimed simply by relief of a...
Source: Journal of Internal Medicine - November 11, 2013 Category: Internal Medicine Authors: F. Sjöberg, M. Singer Tags: Review Source Type: research

Medical management of critical limb ischaemia: where do we stand today?
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - June 26, 2013 Category: Internal Medicine Authors: Matthew A. Lambert, Jill J. F. Belch Tags: Review Source Type: research

Brain perfusion SPECT provides new insight on neurobiological effects of hyperbaric hyperoxia
This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - June 25, 2013 Category: Physiology Authors: Silvia Morbelli, Dario Arnaldi Tags: Editorial Source Type: research

Hyperbaric oxygen preconditioning attenuates hyperglycemia-enhanced hemorrhagic transformation by inhibiting matrix metalloproteinases in focal cerebral ischemia in rats.
Abstract Hyperglycemia dramatically aggravates brain infarct and hemorrhagic transformation (HT) after ischemic stroke. Oxidative stress and matrix metalloproteinases (MMPs) play an important role in the pathophysiology of HT. Hyperbaric oxygen preconditioning (HBO-PC) has been proved to decrease oxidative stress and has been demonstrated to be neuroprotective in experimental stroke models. The present study determined whether HBO-PC would ameliorate HT by a pre-ischemic increase of reactive oxygen species (ROS) generation, and a suppression of MMP-2 and MMP-9 in hyperglycemic middle cerebral artery occlusion (MCA...
Source: Experimental Neurology - March 26, 2013 Category: Neurology Authors: Soejima Y, Hu Q, Krafft PR, Fujii M, Tang J, Zhang JH Tags: Exp Neurol Source Type: research