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Weight loss: indication of brain damage and effect of combined normobaric oxygen and ethanol therapy after stroke.
DISCUSSION: Degree of weight loss after stroke is largely associated with severity of infarction as well as damage reduction after treatment administration. PMID: 25819503 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Long- and Short-term Weight Change and Incident Coronary Heart Disease and Ischemic Stroke: The Atherosclerosis Risk in Communities Study
Weight gain increases the prevalence of obesity, a risk factor for cardiovascular disease. Nevertheless, unintentional weight loss can be a harbinger of health problems. The Atherosclerosis Risk in Communities Study (1987–2009) included 15,792 US adults aged 45–64 years at baseline and was used to compare associations of long-term (30 years) and short-term (3 years) weight change with the risks of coronary heart disease (CHD) and ischemic stroke. Age-, gender-, and race-standardized incidence rates were 4.9 (95% confidence interval (CI): 4.6, 5.2) per 1,000 person-years for CHD and 2.5 (95% CI: 2.3, 2.8) per 1,...
Source: American Journal of Epidemiology - July 16, 2013 Category: Epidemiology Authors: Stevens, J., Erber, E., Truesdale, K. P., Wang, C.-H., Cai, J. Tags: RESEARCH-ARTICLE Source Type: research

Decline of microtubule-associated protein tau after experimental stroke in differently aged wild-type and 3xTg mice with Alzheimer-like alterations
In conclusion, microtubule-associated protein tau was robustly identified as a highly sensitive cytoskeletal constitute under ischemic conditions, suggesting a pivotal role during the transition process toward long-lasting tissue damage. Consequently, cytoskeletal elements appear as promising targets for novel therapeutic approaches with the objective to impede ischemia-induced irreversible cellular degradation.
Source: Neuroscience - June 3, 2016 Category: Neuroscience Source Type: research

Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1
In this study, the neuroprotective effect of Guhong injection (GHI) on middle cerebral artery occlusion (MCAO)-induced reperfusion injury was assessed and the mechanism was explored by RNA-seq technology. GHI administered for 6 consecutive days significantly decreased body weight loss, infarction rate, neurological deficient scores, and neuron loss but improved rat survival percentage and regional cerebral blood flow after MCAO surgery. Furthermore, we identified inflammation as a vital process and C5AR1 as a vital target in GHI-mediated protection by using RNA-seq analysis. Further experiments confirmed that GHI decreased...
Source: Frontiers in Pharmacology - March 21, 2022 Category: Drugs & Pharmacology Source Type: research

Lauric acid provides neuroprotection against oxidative stress in mouse model of hyperglycaemic stroke
Eur J Pharmacol. 2023 Aug 10:175990. doi: 10.1016/j.ejphar.2023.175990. Online ahead of print.ABSTRACTDuring ischemic stroke, higher glucose level linked worse outcomes were reported even in patients without pre-existing diabetes. Evidence suggest that such worse stroke outcomes were mainly due to production of reactive, toxic glucose metabolites that expands oxidative damage inside the brain. As a consequence of high oxidative stress, microvasculature structures and tight junctions compromised their functionally, infarct volume expands and brain edema exacerbates. In a mouse model of ischemic stroke with induced acute hyp...
Source: European Journal of Pharmacology - August 12, 2023 Category: Drugs & Pharmacology Authors: Zaib Ali Shaheryar Mahtab Ahmad Khan Huma Hameed Syed Awais Ali Zaidi Irfan Anjum Muhammad Shafeeq Ur Rahman Source Type: research

Optimised lyophilisation-based method for different biomolecule single-extractions from the same rat brain sample: suitability for RNA and protein expression analyses after ischemic stroke
ConclusionsThe lyophilisation-based method for different biomolecule single-extractions from tissue powder aliquots, representing the same rat brain sample, is sample saving, contributes to the reduction principle in animal research, and allows coordinated analysis for accurate correlations between the transcriptome and proteome in stroke and other neuroscience research.
Source: Journal of Neuroscience Methods - August 22, 2019 Category: Neuroscience Source Type: research

An Unusual Cause Of Recurrent Ischemic Stroke: Trousseau's Syndrome From Gastric Cancer (P4.231)
CONCLUSIONS: Trousseau’s Syndrome must be considered in those presenting with recurrent strokes with an otherwise negative embolic work up especially in the elderly and those with cancer risk factors. It must prompt the clinician to look for an associated malignancy.Disclosure: Dr. JADEJA has nothing to disclose. Dr. Johnson has nothing to disclose. Dr. Soetanto has nothing to disclose. Dr. Nalleballe has nothing to disclose. Dr. DeNiro has nothing to disclose. Dr. Qureshi has nothing to disclose. Dr. Graber has received personal compensation for activities with Stemedica Inc., Novocure Inc., and Biogen Idec.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Jadeja, N., Johnson, J., Soetanto, A., Nalleballe, K., DeNiro, L., Qureshi, I., Graber, J. Tags: Neuro-oncology: Paraneoplastic Disorders Source Type: research

Neuroprotective effects of Danggui-Jakyak-San on rat stroke model through antioxidant/antiapoptotic pathway
Conclusion These suggest that DJ ameliorate the neurological dysfunction of cerebral ischemia through augmentation of antioxidant defense system and up-regulation of STAT3 and Pim-1. Graphical abstract
Source: Journal of Ethnopharmacology - May 16, 2016 Category: Drugs & Pharmacology Source Type: research

Paradoxical Consequence of Human Chorionic Gonadotropin Misuse
This report highlights the potential complications of hCG therapy, particularly when used for unapproved indications and without medical supervision.
Source: Journal of Stroke and Cerebrovascular Diseases - November 8, 2014 Category: Neurology Authors: Mehmet Yasir Pektezel, Demet Funda Bas, Mehmet Akif Topcuoglu, Ethem Murat Arsava Tags: Case Report Source Type: research

Elective ascending aortic aneurysm repair outcomes in a nationwide US cohort
Conclusions The overall rate of in-hospital death, stroke and MI is nearly 5% in patients undergoing elective ascending aortic aneurysm repair. Among several predictors, chronic weight loss is associated with the largest increase in the risk of poor outcomes. Higher hospital volume is associated with a lower in-hospital mortality, highlighting the importance to refer patients to high-volume centres while discussing the risks and benefits of proceeding with repair.
Source: Heart - June 26, 2023 Category: Cardiology Authors: Beyer, S. E., Secemsky, E. A., Khabbaz, K., Carroll, B. J. Tags: Aortic and vascular disease Source Type: research

Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study
CONCLUSION: Weight loss, especially when moving from normal to underweight, was associated with the increased risk of CVD mortality.PMID:34803086 | DOI:10.5551/jat.63191
Source: Journal of Atherosclerosis and Thrombosis - November 22, 2021 Category: Cardiology Authors: Ahmed Arafa Yoshihiro Kokubo Haytham A Sheerah Yukie Sakai Emi Watanabe Jiaqi Li Kyoko Honda-Kohmo Masayuki Teramoto Rena Kashima Masatoshi Koga Source Type: research

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