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Condition: Ischemic Stroke
Nutrition: Antidoxidants

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Total 671 results found since Jan 2013.

The effects of the superoxide dismutase mimetic, MnTMPyP, post hypoxia and oxygen glucose deprivation, in isolated rat hippocampal slices
We report a novel modulatory effect of MnTMPyP on synaptic transmission post hypoxia and OGD, an effect specific to the CA1 region of the hippocampus. This reduction of the fEPSP by MnTMPyP post hypoxia in the CA1 was attenuated through the co-application of the adenosine A1 receptor antagonist, DPCPX (200nM), and the NMDA receptor antagonists, AP-5 (10µM) and DCKA (5µM). These effects were not observed in the OGD model. Our organotypic data demonstrated a protective role for MnTMPyP, where slices had significantly less cell death in the CA1 region post hypoxia and OGD, compared to controls. Taken together, our results s...
Source: Brain Research - October 2, 2022 Category: Neurology Authors: Niamh Moreton Martina Puzio John J O'Connor Source Type: research

Molecules, Vol. 27, Pages 6449: Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury
In conclusion, TPE and TPB exert neuroprotective effects by stimulating the Nrf2 signaling pathway, thereby inhibiting apoptosis.
Source: Molecules - September 30, 2022 Category: Chemistry Authors: Kuan Lin Mei Zhou Changlong Leng Xiaoqing Tao Rong Zhou Youwei Li Binlian Sun Xiji Shu Wei Liu Tags: Article Source Type: research

Crafting ɣ-L-Glutamyl-l-Cysteine layered Human Serum Albumin-nanoconstructs for brain targeted delivery of ropinirole to attenuate cerebral ischemia/reperfusion injury via "3A approach"
Biomaterials. 2022 Sep 15;289:121805. doi: 10.1016/j.biomaterials.2022.121805. Online ahead of print.ABSTRACTTreatment of Ischemic Stroke is inordinately challenging due to its complex aetiology and constraints in shuttling therapeutics across blood-brain barrier. Ropinirole hydrochloride (Rp), a propitious neuroprotectant with anti-oxidant, anti-inflammatory, and anti-apoptotic properties (3A) is repurposed for remedying ischemic stroke and reperfusion (I/R) injury. The drug's low bioavailability in brain however, limits its therapeutic efficacy. The current research work has reported sub-100 nm gamma-L-Glutamyl-L-Cystein...
Source: Biomaterials - September 26, 2022 Category: Materials Science Authors: Saman Fatima Mubashshir Ali Syed Naved Quadri Sarwar Beg M Samim Suhel Parvez Malik Zainul Abdin Prashant Mishra Farhan Jalees Ahmad Source Type: research

Short-term exposure to JUUL electronic cigarettes can worsen ischemic stroke outcome
ConclusionsThese results suggest that JUUL exposure could negatively impact the cerebrovascular system, although to a lesser extent than TS exposure.
Source: Fluids and Barriers of the CNS - September 9, 2022 Category: Neuroscience Source Type: research

Association of Paraoxonase-2 (C1053G) Gene Polymorphism with the Expression of Paraoxonase-2 Gene in Patients of Ischemic Stroke & #8211; A Pilot Study in Indian Population
Conclusion: Down-regulated Paraoxonase-2 gene expression, as evidenced by low mRNA levels in GG genotype may be one of the contributory factors in the progression of ischemic stroke.
Source: Neurology India - August 30, 2022 Category: Neurology Authors: Seema Kumari Ritu Singh Sudhir Chandra Mohit Mehndiratta Ekta Debnath Rajinder K Dhamija Source Type: research

Discovery of 1,2,4-triazole derivatives as novel neuroprotectants against cerebral ischemic injury by activating antioxidant response element
Bioorg Chem. 2022 Aug 13;128:106096. doi: 10.1016/j.bioorg.2022.106096. Online ahead of print.ABSTRACTAcute ischemic stroke is an important cause of death and long-term disability worldwide. In this work, we have synthesized a series of derivatives with 3,5‑diaryl substituent triazole scaffolds. The derivatives showed favorable protective effective in SNP-induced oxidative stress model, of which compound 5 was the most active. In vivo experiments showed that compound 5 could ameliorate neurological deficits, attenuate infarction sizes, reduce malonaldehyde (MDA) level and increase superoxide dismutase (SOD) level in midd...
Source: Bioorganic Chemistry - August 19, 2022 Category: Chemistry Authors: Yaoqiang Lao Ping Huang Jianwen Chen Yang Wang Ruiqi Su Weiyan Shao Wenhao Hu Jingxia Zhang Source Type: research

Chlorogenic acid promotes angiogenesis and attenuates apoptosis following cerebral ischaemia-reperfusion injury by regulating the PI3K-Akt signalling
CONCLUSIONS: CGA effectively repressed apoptosis and promoted angiogenesis in OGD/R-treated HBMECs and MCAO-treated mice by modulating PI3K-Akt signalling. Our research provides a theoretical basis for the use of CGA in the treatment of ischaemic stroke.PMID:35981220 | DOI:10.1080/13880209.2022.2110599
Source: Pharmaceutical Biology - August 18, 2022 Category: Drugs & Pharmacology Authors: Yong Fan Yongkun Li Yongkai Yang Kunzhe Lin Qingqiang Lin Shenghui Luo Xiaohui Zhou Qun Lin Fan Zhang Source Type: research

Molecules, Vol. 27, Pages 5100: Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models
nov Feng Wang Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive role of THC on vascular dysfunction and the development of hypertension by exploring the effects of THC on hemodynamic status, aortic elasticity, and oxidative stress in vasculature in different animal models. We review the protective effects of THC against hypertension induced by heavy metals (cadmium and iron), as well as its impact on arterial stiffness and vascular r...
Source: Molecules - August 10, 2022 Category: Chemistry Authors: Li Zhang Changhu Li Sicheng Wang Dimiter Avtanski Nikola Hadzi-Petrushev Vadim Mitrokhin Mitko Mladenov Feng Wang Tags: Review Source Type: research

Crocins for Ischemic Stroke: A Review of Current Evidence
Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and wel...
Source: Frontiers in Pharmacology - August 5, 2022 Category: Drugs & Pharmacology Source Type: research

Treatment of ischemic stroke with modified mesenchymal stem cells
Int J Med Sci. 2022 Jun 27;19(7):1155-1162. doi: 10.7150/ijms.74161. eCollection 2022.ABSTRACTIschemic stroke is one of the leading causes of death and disability. Ischemia triggers a cascade of events leading to cell death and cerebral infarction. Mesenchymal stem cell (MSC) therapy is a promising treatment modality to promote the development of nerve and blood vessels and improve nerve function. However, MSCs have a limited therapeutic effect in the harsh microenvironment of ischemic brain tissue. Modified MSC therapy shows better therapeutic effect under different pathological conditions, and is expected to be translate...
Source: International Journal of Medical Sciences - August 3, 2022 Category: Biomedical Science Authors: Hao Chen Liangfu Zhou Source Type: research