Chlorogenic acid promotes angiogenesis and attenuates apoptosis following cerebral ischaemia-reperfusion injury by regulating the PI3K-Akt signalling

CONCLUSIONS: CGA effectively repressed apoptosis and promoted angiogenesis in OGD/R-treated HBMECs and MCAO-treated mice by modulating PI3K-Akt signalling. Our research provides a theoretical basis for the use of CGA in the treatment of ischaemic stroke.PMID:35981220 | DOI:10.1080/13880209.2022.2110599

Source: Pharmaceutical Biology - August 18, 2022 Category: Drugs & Pharmacology Authors: Yong Fan Yongkun Li Yongkai Yang Kunzhe Lin Qingqiang Lin Shenghui Luo Xiaohui Zhou Qun Lin Fan Zhang Source Type: research