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Spatial CT perfusion data helpful in automatically locating vessel occlusions for acute ischemic stroke patients
ConclusionThe spatial layout of the hypoperfused region can help to automatically indicate the vessel occlusion location for acute ischemic stroke patients. However, variations in vessel architecture between patients seemed to limit the capacity of CTP data to distinguish between vessel occlusion locations more accurately.
Source: Frontiers in Neurology - March 29, 2023 Category: Neurology Source Type: research

E-081 Susceptibility - Weighted imaging findings in experimental acute ischemic stroke model
ConclusionIn the hyperacute stages of MCAO, SWI images display a consistent and significant signal drop relative to the unaffected side. This signal drop is suspected to result from the paramagnetic effect of deoxyhemoglobin and venodilation and thus an indirect means of visualizing tissue hypoxia.Disclosures N. Saadat: None. G. Christoforidis: 1; C; NIH. M. Niekrasz: None. S. Roth: 1; C; NIH. T. Carroll: 1; C; NIH.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Saadat, N., Christoforidis, G., Niekrasz, M., Roth, S., Carroll, T. Tags: Electronic poster abstracts Source Type: research

Prediction of long-term recurrent ischemic stroke: the added value of non-contrast CT, CT perfusion, and CT angiography
ConclusionData from CT imaging significantly improved the discriminatory performance and reclassification in predicting ischemic stroke recurrence beyond a model incorporating clinical risk factors only.
Source: Neuroradiology - March 17, 2021 Category: Radiology Source Type: research

Multimodal Optical Diagnostics of the Microhaemodynamics in Upper and Lower Limbs
Conclusion The use of optical non-invasive diagnostic methods has a great potential for the detection of concomitant microcirculation disorders in patients with rheumatic diseases and diabetes. In this review, it was shown that the use of laser Doppler flowmetry, optical tissue oximetry and fluorescence spectroscopy together or separately may have important diagnostic value for the detection of violations, assessment of their severity, as well as for the analysis of the effectiveness of the therapy. The joint application of the considered technologies with the methods of machine learning (discriminant analysis) can be use...
Source: Frontiers in Physiology - April 15, 2019 Category: Physiology Source Type: research

Postreperfusion Blood Pressure Variability After Endovascular Thrombectomy Affects Outcomes in Acute Ischemic Stroke Patients With Poor Collateral Circulation
Conclusion: Postreperfusion BP management by decreasing BPV may have influence on improving clinical outcome in cases of poor collateral circulation among patients achieving successful recanalization after ERT. Introduction Endovascular recanalization therapy (ERT) has been adopted as standard stroke care in patients with acute ischemic stroke (1–6). Time to recanalization and degree of recanalization are the most important predictors of clinical outcomes after ERT (7). Before recanalization, an effort to reduce the time from symptom onset to reperfusion is critical for penumbral salvage. After recanalization...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Wake-Up Stroke versus Stroke with Known Onset Time: Clinical and Multimodality CT Imaging Characteristics
Conclusions: There are only minor differences between clinical and imaging characteristics of WUS patients and patients who arrive in the hospital within the time criteria for intravenous or endovascular treatment. Therefore, CT imaging may help to identify WUS patients who would benefit from treatment and rule out those patients with severe ischemia and poor collaterals.Cerebrovasc Dis 2018;45:236 –244
Source: Cerebrovascular Diseases - May 17, 2018 Category: Neurology Source Type: research

Computed Tomography Perfusion Derived Blood-Brain Barrier Permeability Does Not Yet Improve Prediction of Hemorrhagic Transformation
Conclusion: BBBP predicts HT but does not improve prediction with age and admission NIHSS.Cerebrovasc Dis 2018;45:26 –32
Source: Cerebrovascular Diseases - January 8, 2018 Category: Neurology Source Type: research

Prediction of Clinical Outcome After Acute Ischemic Stroke Brief Report
Conclusions—Follow-up imaging after 3 days improves outcome prediction compared with prediction based on baseline variables alone. CTA recanalization and CTP reperfusion do not outperform noncontrast CT at this time point.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00880113.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Jan W. Dankbaar, Alexander D. Horsch, Andor F. van den Hoven, L. Jaap Kappelle, Irene C. van der Schaaf, Tom van Seeters, Birgitta K. Velthuis Tags: Computerized Tomography (CT), Prognosis, Ischemic Stroke Brief Reports Source Type: research

E-045 Nihss and its component subscores are suboptimal predictors with colinearity
Conclusions NIHSS composite score is a suboptimal predictor for assessed patient outcomes. Principal component analysis improves predictive value of assessment with a statistically significant effect for pre-intervention patient outcomes analysis. Statistically significant variables are heavily dependent of NIHSS subscores, and variation in the distribution of these subscore may represent a significant source of bias. References . OA Berkhemer, et al. MR CLEAN, a multicenter randomized clinical trial of endovascular treatment for acute ischemic stroke in the Netherlands: new england journal of med 372;1 nejm.org january 1...
Source: Journal of NeuroInterventional Surgery - July 23, 2017 Category: Neurosurgery Authors: Arndt, S., Albar, A., Bennett, G., Lavie, J., Gulotta, P., Milburn, J. Tags: Electronic Poster Abstracts Source Type: research