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Condition: Ischemic Stroke
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Total 149 results found since Jan 2013.

Nrf2/antioxidant defense pathway is involved in the neuroprotective effects of Sirt1 against focal cerebral ischemia in rats after hyperbaric oxygen preconditioning.
Abstract Sirtuin 1 (Sirt1) is a class III histone deacetylase involved in neuroprotection induced by hyperbaric oxygen preconditioning (HBO-PC) in animal models of ischemia. However, the underlying mechanisms remain to be illustrated. In the present study, rats exposed to middle cerebral artery occlusion (MCAO) were used to establish an ischemic stroke model. The infarct volume ratio, neurobehavioral score, and expressions of Sirt1, nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and superoxide dismutase 1 (SOD1) were evaluated at 7days after reperfusion, and the level of malondialdehy...
Source: Behavioural Brain Research - April 26, 2016 Category: Neurology Authors: Xue F, Huang JW, Ding PY, Zang HG, Kou ZJ, Li T, Fan J, Peng ZW, Yan WJ Tags: Behav Brain Res Source Type: research

A Single-Nucleotide Polymorphism in 3'-Untranslated Region of Endothelin-1 Reduces Risk of Dementia After Ischemic Stroke.
CONCLUSIONS Our study demonstrated the pathogenesis mechanism during the development of dementia after ischemic stroke by investigating the relationship between miR-125a and its target ET-1, promising a potential pathological solution for post-stroke dementia in the future. PMID: 27106952 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - April 25, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Drp‐1, a potential therapeutic target for brain ischaemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 increases the resistance of neurons of hippocampal CA3 affected by global ischaemia and contributes to the tolerance conferred by IPC highlight Drp‐1 as a potential therapeutic target for brain ischaemic stroke.
Source: British Journal of Pharmacology - April 6, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

GPER expressed on microglia mediates the anti‐inflammatory effect of estradiol in ischemic stroke
ConclusionsOur studies have suggested that GPER expressed on microglia mediated the anti‐inflammatory effect of estradiol after ischemic stroke. Our studies could potentially help to develop more specific drugs to manage inflammation postischemic stroke. GPER was highly expressed in activated microglia after ischemia and estradiol. The specific GPER agonist G1 could inhibit the secretion of proinflammatory cytokines including IL‐1β and TNF‐α, which the anti‐inflammatory effect of G1 and E2 were both abolished by the specific GPER antagonist G15.
Source: Brain and Behavior - March 21, 2016 Category: Neurology Authors: Tian‐Zhi Zhao, Qian Ding, Jun Hu, Shi‐Ming He, Fei Shi, Lian‐Ting Ma Tags: Original Research Source Type: research

Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3
Abstract Leukemia inhibitory factor (LIF) has been shown to protect oligodendrocytes from ischemia by upregulating endogenous antioxidants. The goal of this study was to determine whether LIF protects neurons during stroke by upregulating superoxide dismutase 3 (SOD3). Animals were administered phosphate-buffered saline (PBS) or 125 μg/kg LIF at 6, 24, and 48 h after middle cerebral artery occlusion or sham surgery. Neurons were isolated from rat pups on embryonic day 18 and used between 7 and 15 days in culture. Cells were treated with LIF and/or 10 μM Akt inhibitor IV with PBS and 0.1 % DMSO acting as veh...
Source: Molecular Neurobiology - January 9, 2016 Category: Neurology Source Type: research

Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.
In conclusion, andrographolide increased Nrf2-HO-1 expression through p38 MAPK regulation, confirming that it provides protection against MCAO-induced brain injury. These findings provide strong evidence that andrographolide could be a therapeutic agent for treating ischemic stroke or neurodegenerative diseases. PMID: 26746802 [PubMed - as supplied by publisher]
Source: Translational Research : the journal of laboratory and clinical medicine - December 17, 2015 Category: Laboratory Medicine Authors: Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR Tags: Transl Res Source Type: research

siRNA mediated down-regulation of Sprouty2/4 diminishes ischemic brain injury
In this study, siRNAs directed against Sprouty2 and -4 were stereotactically injected along with the vasoconstrictive peptide endothelin-1 to create cortical infarcts in the adult rat brain. A single injection of Sprouty2/4 siRNAs (25μM each) significantly decreased Spry2 and Spry4 mRNA levels two days later and diminished the size of the injury area in the subchronic phase following vasoconstriction. Reducing Spry2/4 genetically in mice is neuroprotective and stimulates injury-induced astrogliosis which limits neuronal cell death and lesion size. The present results are consistent with the established functions of negati...
Source: Neuroscience Letters - December 4, 2015 Category: Neuroscience Source Type: research

Increases in intracellular calcium perturb blood–brain barrier via protein kinase C-alpha and apoptosis
This study reveals successive increases in intracellular calcium levels and protein kinase C-α activity are key mechanisms in OGD±R-mediated impairment of BBB. Furthermore inhibition of protein kinase C-α may be therapeutic in restoring BBB function by reducing the rate of cytoskeletal reorganisation, oxidative stress and apoptosis. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 25, 2015 Category: Molecular Biology Source Type: research

Micro‐RNA‐30a regulates ischemia‐induced cell death by targeting heat shock protein HSPA5 in primary cultured cortical neurons and mouse brain after stroke
Micro‐RNAs (miRs) have emerged as key gene regulators in many diseases, including stroke. We recently reported that miR‐30a protects N2A cells against ischemic injury, in part through enhancing beclin 1‐mediated autophagy. The present study explores further the involvement of miR‐30a in ischemia‐induced apoptosis and its possible mechanisms in primary cortical neurons and stroked mouse brain. We demonstrate that miR‐30a level is significantly decreased in cortical neurons after 1‐hr oxygen–glucose deprivation (OGD)/24‐hr reoxygenation. Overexpression of miR‐30a aggravated the OGD‐induced neuronal cell...
Source: Journal of Neuroscience Research - August 24, 2015 Category: Neuroscience Authors: Peng Wang, Nan Zhang, Jia Liang, Jiefei Li, Song Han, Junfa Li Tags: Research Article Source Type: research

Autophagy protects Human Brain Microvascular Endothelial Cells against Methylglyoxal‐induced Injuries: in parallel with Cerebral Ischemic Model in Diabetic Rats
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - August 1, 2015 Category: Neurology Authors: Lili Fang, Xue Li, Yinbo Zhong, Jing Yu, Lina Yu, Haibin Dai, Min Yan Tags: Original Article Source Type: research

Osteopontin Mediates Hyperbaric Oxygen Preconditioning-Induced Neuroprotection Against Ischemic Stroke
Abstract Neurosurgical operations may result in surgical injury which would lead to postoperative neurological deficits. Hyperbaric oxygen preconditioning (HBO-PC) may be beneficial for such people. However, the exact mechanism underlying HBO-PC is not well known yet. The aim of this study is to explore the role of osteopontin (OPN) in HBO-PC-induced neuroprotection. The study consisted of two experiments. In experiment 1, Sprague Dawley (SD) rats were divided into four groups: sham group, HBO-PC sham group, stroke group, and HBO-PC group (HBO-PC + stroke). The animals in the second experiment were randomly a...
Source: Molecular Neurobiology - July 21, 2015 Category: Neurology Source Type: research

Silencing of Id2 attenuates hypoxia/ischemia-induced neuronal injury via inhibition of neuronal apoptosis.
This study was aimed to investigate whether knockdown of Id2 in neuronal cells could protect them from hypoxic and ischemic injury both in vitro and in vivo. Flow cytometric analysis was employed to assess neuronal apoptosis in CoCl2-treated neuroblastoma B35 cells engineered to overexpress or knockdown Id2 expression. In vivo knockdown of Id2 was performed in Sprague-Dawley rats by a single intracerebroventricular injection of Cy3-labeled and cholesterol-modified Id2-siRNA. We found that knockdown of Id2 attenuated H/I-induced neuronal apoptosis in vitro while overexpression of Id2 produced an opposite effect. In a rat mo...
Source: Behavioural Brain Research - July 14, 2015 Category: Neurology Authors: Guo L, Yang X, Lin X, Lin Y, Shen L, Nie Q, Ren L, Guo Q, Que S, Qiu Y Tags: Behav Brain Res Source Type: research

PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription
Abstract Peroxisome proliferator-activated receptor-gamma (PPAR-γ), a stress-induced transcription factor, protects neurons against ischemic stroke insult by reducing oxidative stress. NADPH oxidase (NOX) activation, a major driving force in ROS generation in the setting of reoxygenation/reperfusion, constitutes an important pathogenetic mechanism of ischemic brain damage. In the present study, both transient in vitro oxygen-glucose deprivation and in vivo middle cerebral artery (MCA) occlusion-reperfusion experimental paradigms of ischemic neuronal death were used to investigate the interaction between PPAR-γ a...
Source: Molecular Neurobiology - June 24, 2015 Category: Neurology Source Type: research

Neuroprotection of Sanhua Decoction against Focal Cerebral Ischemia/Reperfusion Injury in Rats through a Mechanism Targeting Aquaporin 4.
In conclusion, SHD exerted neuroprotection against focal cerebral I/R injury in rats mainly through a mechanism targeting AQP4. PMID: 26089944 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - June 21, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research