Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats.

In conclusion, andrographolide increased Nrf2-HO-1 expression through p38 MAPK regulation, confirming that it provides protection against MCAO-induced brain injury. These findings provide strong evidence that andrographolide could be a therapeutic agent for treating ischemic stroke or neurodegenerative diseases. PMID: 26746802 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26746802?dopt=Abstract

Source: Translational Research : the journal of laboratory and clinical medicine - December 17, 2015 Category: Laboratory Medicine Authors: Yen TL, Chen RJ, Jayakumar T, Lu WJ, Hsieh CY, Hsu MJ, Yang CH, Chang CC, Lin YK, Lin KH, Sheu JR Tags: Transl Res Source Type: research