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Condition: Anaphylactic Shock
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Total 7645 results found since Jan 2013.
Single-step direct drug provocation testing is safe for de-labelling selected "non-low-risk" penicillin allergy labels
CONCLUSION: In our cohort, direct single-step DPT was safe with only 6 patients with "non-low risk" allergy experiencing benign reactions. We hope further study can be performed into single-step direct DPT for interrogating "non-low risk" penicillin allergy labels.PMID:33865989 | DOI:10.1016/j.anai.2021.04.008
Source: Annals of Allergy, Asthma and Immunology - April 18, 2021 Category: Allergy & Immunology Authors: Jamma Li Vera Cvetanovski B Nursing Suran Fernando Source Type: research
Allergy to lipid transfer proteins (LTP) in a pediatric population
Eur Ann Allergy Clin Immunol. 2021 Jul 23. doi: 10.23822/EurAnnACI.1764-1489.229. Online ahead of print.ABSTRACTLipid transfer proteins (LTP) are considered important plant-food allergens in the Mediterranean area, but little is known about LTP allergy in pediatric age. Our aim was to characterize LTP allergy in children.We reviewed the clinical data from all children evaluated in our department with LTP allergy. From the 76 patients with LTP allergy, 26 children were included, 50% female, median age 10 years (1-17). Symptoms included urticaria in 58% (n = 15), 168 anaphylaxes in 46% (n = 12) and OAS in 42% (n = 11). Multi...
Source: European Annals of Allergy and Clinical Immunology - July 23, 2021 Category: Allergy & Immunology Authors: J Barradas Lopes C Santa C Valente A R Presa M Jo ão Sousa A Reis Ferreira Source Type: research
Combining Anti-IgE Monoclonal Antibodies and Oral Immunotherapy for the Treatment of Food Allergy
AbstractImmunoglobulin E (IgE)-mediated food allergy is a real public health problem worldwide. The prevalence of food allergy is particularly high in children. Patients with food allergy experience high morbidity with a change in quality of life due to the risk of severe anaphylaxis. Current treatment options are poor. Allergen avoidance is widely recommended but exposes patients to accidental ingestion. Oral immunotherapy is also used in patients with food allergies to the most common allergens. Oral immunotherapy consists of a daily administration of small, gradually increasing amounts of allergens to induce desensitisa...
Source: Clinical Reviews in Allergy and Immunology - September 22, 2021 Category: Allergy & Immunology Source Type: research
Safe De-Labeling of Patients at Low Risk of Penicillin Allergy in Denmark
Conclusion: The risk stratification criteria for identifying low-risk patients for the oral drug provocation test without prior skin testing were safe in terms of avoiding anaphylaxis or severe delayed hypersensitivity. Benign delayed skin reactions still occurred, and access to allergy advice and follow-up is necessary.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - February 2, 2022 Category: Allergy & Immunology Source Type: research
Do No Harm: Risk vs. Benefit of the Approach to Childhood Food Allergy
Opinion statementThe prevalence of food allergy is rising across much of the world, but the rate of fatal food anaphylaxis appears generally stable. Given the negligible impact on overall mortality risk from fatal food anaphylaxis in children, probable overdiagnosis of food allergy, and the large psychosocial burden caused by this disease, we aim to reassure patients, families, and allergists regarding risk and propose solutions to improve the current approach to childhood food allergy. Data suggests that children labelled food allergic and their parents frequently overestimate their food allergy risk, leading to excessive...
Source: Current Treatment Options in Allergy - October 26, 2022 Category: Allergy & Immunology Source Type: research
Analysis of the Safety of Drug Allergy Workups in a Spanish University Hospital: Drug Characteristics, Type of Reaction, and Patients ’ Age at the Initial Assessment
Conclusion: We conclude that clinical practice in the diagnosis of drug allergy in our Allergy Department is safe, without over-diagnosis.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 12, 2023 Category: Allergy & Immunology Source Type: research
Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report
Allergy immunotherapy (AIT) is an effective treatment for allergic asthma and rhinitis, as well as venom-induced anaphylaxis. In addition to reducing symptoms, AIT can change the course of allergic disease and induce allergen-specific immune tolerance. In current clinical practice immunotherapy is delivered either subcutaneously or sublingually; some allergens, such as grass pollen, can be delivered through either route, whereas others, such as venoms, are only delivered subcutaneously. Both subcutaneous and sublingual immunotherapy appear to have a duration of efficacy of up to 12 years, and both can prevent the developme...
Source: Journal of Allergy and Clinical Immunology - March 15, 2013 Category: Allergy & Immunology Authors: A. Wesley Burks, Moises A. Calderon, Thomas Casale, Linda Cox, Pascal Demoly, Marek Jutel, Harold Nelson, Cezmi A. Akdis Tags: PRACTALL consensus report Source Type: research
Role of specific IgE in predicting the clinical course of lentil allergy in children
ConclusionsOur results suggest that sIgE levels may be important for predicting clinical reactivity and persistence of lentil allergy.
Source: Pediatric Allergy and Immunology - May 21, 2013 Category: Allergy & Immunology Authors: Suleyman T. Yavuz, Umit M. Sahiner, Betul Buyuktiryaki, Ayfer Tuncer, Ebru A. Yilmaz, Ozlem Cavkaytar, Erdem Karabulut, Cansin Sackesen Tags: Original Article Source Type: research
A UK national survey of investigations for beta‐lactam hypersensitivity – heterogeneity in practice and a need for national guidelines – on behalf of British Society for Allergy and Clinical Immunology (BSACI)
Conclusion and clinical relevanceThis survey revealed variation in the investigation and management of BL hypersensitivity in the UK with some centres reporting procedures that could potentially put patients at risk of anaphylaxis if allergy was falsely excluded. This survey highlights an urgent need for evidence based national guidelines and standardisation of practice.
Source: Clinical and Experimental Allergy - July 29, 2013 Category: Allergy & Immunology Authors: A. G. Richter, S. M. Nasser, M. T. Krishna Tags: Original Article Source Type: research
Serum basal tryptase may be a good marker for predicting the risk of anaphylaxis in children with food allergy
In this study, children with food allergy (FA; n = 167) were analyzed in two groups according to the presence (FA+/A+; n = 79) or absence of anaphylaxis (FA+/A−; n = 88) and were compared with a control group (n = 113). Median sBT values in FA+/A+, FA+/A−, and control groups were 4.0 ng/ml (2.8–5.8), 3.6 (2.3–4.5), and 3.3 (2.4–4.4), respectively (P = 0.022). sBT measurements higher than the cutoff values of 5.7 and 14.5 were associated with 50% and 90% predicted probabilities, respectively, of moderate to severe anaphylaxis. Children with tree nuts/peanut allergies had significantly higher levels of s...
Source: Allergy - November 20, 2013 Category: Allergy & Immunology Authors: U. M. Sahiner, S. T. Yavuz, B. Buyuktiryaki, O. Cavkaytar, E. A. Yilmaz, A. Tuncer, C. Sackesen Tags: Brief Communication Source Type: research
Treatment of allergic reactions and quality of life among caregivers of food-allergic children.
CONCLUSION: The effect of epinephrine use on caregiver QoL is conditional and depends on reaction severity. Having multiple FAIs and FAIs with multiple food allergies was associated with worsening QoL. Further studies are needed to better understand the effects of treating an allergic reaction on caregiver QoL.
PMID: 25660416 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - February 5, 2015 Category: Allergy & Immunology Authors: Ward CE, Greenhawt MJ Tags: Ann Allergy Asthma Immunol Source Type: research
Clinical and immunochemical profiles of food challenge proven or anaphylactic shrimp allergy in tropical Singapore
Conclusions and Clinical RelevanceThis study highlights the predominance of oral symptoms in shrimp allergy in tropical Asia and that a high provocation dose may be necessary to reveal shrimp allergy. Furthermore, specific IgE diagnostic tests and immunoblots were of limited use in this population.
Source: Clinical and Experimental Allergy - February 25, 2015 Category: Allergy & Immunology Authors: M. Thalayasingam, I. F. A. Gerez, G. C. Yap, G. V. Llanora, I. P. Chia, L. Chua, C. J. A. O. Lee, L. D. H. Ta, Y. K. Cheng, B. Y. H. Thong, C. Y. Tang, H. P. S. Van Bever, L. P. Shek, M. A. Curotto de Lafaille, B. W. Lee Tags: Original Article Source Type: research
