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Condition: Anaphylactic Shock

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A regional approach to unmet needs in anaphylaxis.
Authors: Minale P, Bignardi D, Troise C, Voltolini S, Dignetti P Abstract Allergic diseases are under-diagnosed and undertreated despite their wide prevalence, and particularly anaphylaxis is often under-estimated. Evidence-based anaphylaxis guidelines developed by principal allergy organizations agree on increased prevalence of anaphylaxis, especially in patients younger than 18 years (18-27,30): this trend highlights the need for actions on anaphylaxis management and prevention (3,4). Lack of prompt connection between emergency department and allergy unit after discharge, and of a dedicated ICD-9th identification...
Source: European Annals of Allergy and Clinical Immunology - May 8, 2016 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Anaphylaxis in the Pediatric Emergency Department: Analysis of 133 Cases After an Allergy Workup
Conclusions The incidence of anaphylaxis is higher in children than previously reported in adults from the same center, and food is the trigger in most cases. To prevent erroneous diagnoses, the etiology of anaphylaxis should be established after an appropriate workup.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 25, 2017 Category: Allergy & Immunology Source Type: research

Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis
Purpose of review: Animal models published within the past 18 months on asthma, food allergy and anaphylaxis, all conditions of rising public health concern, were reviewed. Recent findings: While domestic animals spontaneously develop asthma, food allergy and anaphylaxis, in animal models, divergent sensitization and challenge routes, dosages, intervals and antigens are used to induce asthmatic, food allergic or anaphylactic phenotypes. This must be considered in the interpretation of results. Instead of model antigens, gradually relevant allergens such as house dust mite in asthma, and food allergens like peanut, apple a...
Source: Current Opinion in Allergy and Clinical Immunology - April 27, 2017 Category: Allergy & Immunology Tags: OUTCOME MEASURES: Edited by Henry Milgrom and R. Maximiliano Gomez Source Type: research

Spontaneous food allergy in Was −/− mice occurs independent of FcεRI‐mediated mast cell activation
ConclusionsWas−/− mice provide a model of food allergy with the advantage of mimicking polysensitization and low food‐antigen IgE titers as observed in humans with clinical food allergy. This model will facilitate studies on aberrant immune responses during spontaneous disease development. Our results imply that therapeutic targeting of the IgE/FcεRI activation cascade will not affect sensitization to food.
Source: Allergy - July 14, 2017 Category: Allergy & Immunology Authors: W. S. Lexmond, J. A. Goettel, B. F. Sallis, K. McCann, E. H. H. M. Rings, E. Jensen ‐Jarolim, S. Nurko, S. B. Snapper, E. Fiebiger Tags: ORIGINAL ARTICLE Source Type: research

Cocaine Allergy in Drug-Dependent Patients and Allergic People
Conclusions Cocaine may be an important allergen. Drug abusers and patients sensitized to local anesthesia and tobacco are at risk. Both prick tests and specific IgE against coca leaf extract detected sensitization to cocaine. The highest levels were related to severe clinical profiles.
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 30, 2017 Category: Allergy & Immunology Source Type: research

Twenty years ’ experience with anaphylaxis-like reactions to local anesthetics: genuine allergy is rare
Conclusions Skin testing and provocative LA challenge are useful to exclude LA allergy, and this testing procedure seems to be appropriate to identify the extremely rare cases with IgE-mediated LA allergy.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 13, 2018 Category: Allergy & Immunology Source Type: research

A regional approach to unmet needs in anaphylaxis.
Authors: Minale P, Bignardi D, Troise C, Voltolini S, Dignetti P Abstract Allergic diseases are under-diagnosed and undertreated despite their wide prevalence, and particularly anaphylaxis is often under-estimated. Evidence-based anaphylaxis guidelines developed by principal allergy organizations agree on increased prevalence of anaphylaxis, especially in patients younger than 18 years (18-27,30): this trend highlights the need for actions on anaphylaxis management and prevention (3,4). Lack of prompt connection between emergency department and allergy unit after discharge, and of a dedicated ICD-9th identification...
Source: European Annals of Allergy and Clinical Immunology - September 15, 2018 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

A Multicenter Evaluation of Diagnosis and Management of Omega-5 Gliadin Allergy (Also Known as Wheat-Dependent Exercise-Induced Anaphylaxis) in 132 Adults
ConclusionOmega-5 gliadin allergy is a rare wheat allergy that presents with severe anaphylaxis. The diagnosis is frequently delayed, and therefore we recommend that all adult patients presenting with anaphylaxis of unclear cause should have omega-5 gliadin specific IgE tested. A gluten-free diet or avoidance of wheat-based meals in combination with exercise (if the cofactor is exercise) helps to significantly decrease the risk of future allergic reactions. However, antihistamines and an epinephrine autoinjector must always be prescribed because one-third of patients continue to have allergic reactions despite dietary advice.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 2, 2018 Category: Allergy & Immunology Source Type: research

Chlorhexidine Allergy: On the Rise and Often Overlooked
AbstractPurpose of ReviewIn recent years, the risk of allergy to chlorhexidine is increasingly recognised. In this review, we discuss why the allergy is so easily overlooked and point out several preventative initiatives that can minimise the risk of both chlorhexidine sensitisation and allergy development and accidental re-exposure in patients with chlorhexidine allergy. Testing for chlorhexidine allergy is also discussed.Recent FindingsNumerous reports have been published from many different specialties. Symptoms range from mild skin symptoms to life-threatening anaphylaxis. Testing for chlorhexidine allergy is based on ...
Source: Current Allergy and Asthma Reports - March 13, 2019 Category: Allergy & Immunology Source Type: research

Prevalence and Characteristics of Shellfish Allergy in the Pediatric Population of the United States
ConclusionThe epidemiology of SA in the US pediatric population shows crustacean allergy is more common than mollusk allergy. A disparity in SA children and epinephrine auto-injector carriage exists. Results from this study will lead to increased awareness of the need for detailed histories, specific diagnostic tests, and rescue epinephrine for anaphylaxis in US children with SA.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 7, 2020 Category: Allergy & Immunology Source Type: research

Change in Allergy Practice during the COVID-19 Pandemic
Conclusions: Allergists in Turkey have been using telemedicine at a high rate during the COVID-19 pandemic for asthma and rhinitis. The continuation rate of SCIT was low while the discontinuation rate of biologicals and systemic steroid use in asthma was high in Turkey.Our study results and learning from the experiences of other countries and specialties may help to optimize allergy practice and compatibility with international guidelines.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - October 15, 2020 Category: Allergy & Immunology Source Type: research

Single-step direct drug provocation testing is safe for de-labelling selected "non-low-risk" penicillin allergy labels
CONCLUSION: In our cohort, direct single-step DPT was safe with only 6 patients with "non-low risk" allergy experiencing benign reactions. We hope further study can be performed into single-step direct DPT for interrogating "non-low risk" penicillin allergy labels.PMID:33865989 | DOI:10.1016/j.anai.2021.04.008
Source: Annals of Allergy, Asthma and Immunology - April 18, 2021 Category: Allergy & Immunology Authors: Jamma Li Vera Cvetanovski B Nursing Suran Fernando Source Type: research