Chlorhexidine Allergy: On the Rise and Often Overlooked

AbstractPurpose of ReviewIn recent years, the risk of allergy to chlorhexidine is increasingly recognised. In this review, we discuss why the allergy is so easily overlooked and point out several preventative initiatives that can minimise the risk of both chlorhexidine sensitisation and allergy development and accidental re-exposure in patients with chlorhexidine allergy. Testing for chlorhexidine allergy is also discussed.Recent FindingsNumerous reports have been published from many different specialties. Symptoms range from mild skin symptoms to life-threatening anaphylaxis. Testing for chlorhexidine allergy is based on skin testing and in vitro testing. Recently, it was found that both skin prick testing and specific IgE have high sensitivities and specificities.SummaryThis review gives an overview of chlorhexidine allergy with a special focus on preventative initiatives and testing.
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research

Related Links:

This article was originally published on Undark. Read the original article.
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized allergies health onetime syndication Source Type: news
ConclusionsThis analysis confirms that treatment with intravenous reslizumab for>12 months is well tolerated in patients with asthma, with no evidence of rare safety events that were not detected in individual trials.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Drug-induced hypersensitivity reactions are of major medical concern. Approximately 45% of all the adverse drug reactions are manifested in the skin, which occur in 2%-3% hospitalized patients upon drug administration1. Drug hypersensitivity reactions can be categorized into immediate reactions and delayed reactions. Immediate reactions occur within minutes or hours of drug exposure 2. The manifestations of immediate-type reactions range from pruritus, urticaria, angioedema to anaphylaxis. The delayed-type reactions are primarily T cell-mediated type IV reactions that usually takes several days or even weeks to manifest after drug exposure.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Hypersensitivity reactions to fruit, particularly apples, stone fruits and bananas, are commonly reported.1 One fruit less frequently described in the literature causes adverse reactions in many patients: pineapple (Ananas comosus). Pineapple is best known in developed countries for its sweet and tangy coalesced berries, but its anti-inflammatory properties and enzymatic activity have been used for centuries.2 Despite its pleasant taste and putative salutary effects, pineapple has been implicated in an array of adverse reactions including uncomfortable mucosal irritation due to acidic pH and bromelain, oral allergy syndrom...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Tryptase is produced primarily by mast cells. Mast cell degranulation results in release of tryptase and anaphylaxis may result in elevated tryptase levels, with return to normal levels over a few hours.1 Persistent or episodic elevation of tryptase levels can be indicative of increased body mast cell burden or mast cell activation, typically seen in mastocytosis and mast cell activation disorder (MCAD).2 Elevated serum tryptase levels represent a significant risk factor for severe anaphylaxis to hymenoptera stings.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
CONCLUSIONS: Wheat, fruits with or without PFAS, and crustaceans are important and frequent causative allergens in Korean adult FA; these allergens differ from those found in childhood FA. It is notable that non-classic allergies, such as PFAS, FDEIA, and α-Gal allergy, are the important causes of anaphylaxis in Korean adult FA. PMID: 31332982 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Gelatin is an animal-derived proteinaceous substance found in foods, cosmetics, and medical supplies. It is generated by partial hydrolysis and treatment of collagen, commonly porcine or bovine. The result is a heterogenous mixture of water-soluble proteins with gel-forming properties that lends its texture to foods like marshmallows and jellies.1,2 This and other properties have been exploited for medical purposes such as in pill capsules, hemostatic agents, and vaccines.3 For people who are allergic to gelatin, the pervasive and sometimes hidden nature of this allergen in medical supplies presents a unique problem and a ...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research
PMID: 31351979 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Abstract Gluten-related disorders are very common in pediatric patients. Wheat allergy is triggered by an immunoglobulin E (IgE)-dependent mechanism; its prevalence varies according to the age and region, and in Europe has been estimated to be lower than 1%. Many studies investigated the potential role of several external factors that can influence the risk to developing wheat allergy, but results are still inconclusive. It can be responsible for several clinical manifestations depending on the route of allergen exposure: food-dependent exercise-induced anaphylaxis (FDEIA), occupational rhinitis or asthma (also kn...
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
sso M Abstract Blomia tropicalis mite is highly prevalent in tropical and subtropical regions and it is associated with allergic diseases such as rhinitis and asthma. By using an OVA-model of allergic lung disease, we have previously shown that sensitization in the presence of toll like receptors (TLRs) agonists attenuates subsequent OVA-induced allergic responses. Here, we evaluated the effect of CpG-ODN, a specific synthetic TLR-9 agonist, on the development of experimental asthma induced by Blomia tropicalis extract, a relevant source of aeroallergens. Among different protocols of Blomia tropicalis extract sens...
Source: Journal of Leukocyte Biology - Category: Hematology Authors: Tags: J Leukoc Biol Source Type: research
More News: Allergy | Allergy & Immunology | Anaphylactic Shock | Asthma | Chlorhexidine | Skin