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Specialty: Biochemistry
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Total 384 results found since Jan 2013.

Stroke in women: Risk factors and clinical biomarkers
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Source: Journal of Cellular Biochemistry - May 12, 2017 Category: Biochemistry Authors: Hamed Mirzaei Tags: Article Source Type: research

Association of LDLc to HDLc ratio with carotid plaques in a community-based population with a high stroke risk: a cross-sectional study in China.
CONCLUSION: Higher LDLc/HDLc was significantly associated with the presence of carotid plaques in the Chinese population with a high risk of stroke. PMID: 33242435 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - November 23, 2020 Category: Biochemistry Authors: Geng Y, Liu Y, Chen Y, Zhang Z, Wang L, Li X, Xia B, Song B, Zhang H Tags: Clin Biochem Source Type: research

Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice.
In conclusion, we found no correlation between acute neuroprotection (occurring in both T2D and normal mice) and increased NSC proliferation (occurring only in T2D mice). However, our results show that linagliptin evokes a differential response on NSC proliferation after stroke in normal and T2D mice suggesting that DPP-4 inhibition effect in the CNS might go beyond the well known increase of GLP-1. PMID: 24821550 [PubMed - as supplied by publisher]
Source: Regulatory Peptides - May 9, 2014 Category: Biochemistry Authors: Darsalia V, Olverling A, Larsson M, Mansouri S, Nathanson D, Nyström T, Klein T, Sjöholm A, Patrone C Tags: Regul Pept Source Type: research

Down regulation of brain cellular prion protein in an animal model of insulin resistance: Possible implication in increased prevalence of stroke in pre-diabetics/diabetics.
Abstract The risk of stroke is drastically increased in diabetic and pre-diabetic patients. The worldwide spread of obesity and insulin resistance increases the incidence of stroke. The direct effect of insulin resistance, as it pertains to stroke, on the central nervous system is not well understood. Since one of the physiological functions of the cellular prion protein (PrP(C)) is neuroprotection, we studied effects of brain insulin resistance on the expression of PrP(C) in fructose-fed rats as an animal model of prediabetes. Compared with control chow-fed animals, rats fed a high-fructose diet (FF), exhibited c...
Source: Biochemical and Biophysical Research communications - April 26, 2014 Category: Biochemistry Authors: Pham N, Khalaj S, Dhar A, Desai K, Taghibiglou C Tags: Biochem Biophys Res Commun Source Type: research

Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents
Fitoterapia. 2022 Dec 20:105398. doi: 10.1016/j.fitote.2022.105398. Online ahead of print.ABSTRACTPiper longum has a specific aroma and spicy taste. In addition to edible value, current studies have shown that piper longum also has pharmacological activities such as anti-platelet aggregation, anti-inflammation, anti-cancer, anti-diabetes and anti-depression. Piperlongumine is an alkaloid isolated from Piper longum. Based on our previous studies, four Piperlongumine analogs were synthesized, and their anti-platelet aggregation activities were evaluated. Among them, compound 8 has the strongest anti-platelet aggregation acti...
Source: Fitoterapia - December 23, 2022 Category: Biochemistry Authors: Tan Lijuan Cao Xiaolu Wan Xin He Yuying Lan Xi Yang Xiliang Wang Ting Min Zhenli Zou Yu Source Type: research

Diets enriched in whey or casein improve energy balance, prevent morbidity and renal damage in salt-loaded and high-fat fed spontaneously hypertensive stroke-prone rats
High-fat diets induce obesity and increase risks of diabetes, cardiovascular and renal disorders. Whey or casein enriched diets decrease food intake and weight gain; however, their cardiovascular and renal benefits are unclear. We determined whether whey and casein enriched diets improve energy balance and are protective against renal damage and morbidity associated with stroke in an obesogenic and hypertensive experimental setting. We also assessed whether the hypophagic effects of these diets were due to reduced diet preference.
Source: The Journal of Nutritional Biochemistry - August 12, 2016 Category: Biochemistry Authors: Arashdeep Singh, Adel Pezeshki, Rizaldy C. Zapata, Nicholas J. Yee, Cameron G. Knight, Ursula I. Tuor, Prasanth K. Chelikani Source Type: research

Association of vaspin gene expression and its serum level on the risk of ischemic stroke in type 2 diabetic Egyptian patients: Prospective case ‐control study
In conclusion, the higher levels of serum vaspin and vaspin expression levels in T2DM emphasizes the pivotal role of vaspin serum level and expression in the progression of metabolic and glucose abnormalities, thus, they could be used as biomarkers of IS.
Source: Biotechnology and Applied Biochemistry - January 13, 2021 Category: Biochemistry Authors: Nearmeen M. Rashad, Hanan S. Ahmed, Waleed M. Reda Ashour, Mohammed S. Yousef Tags: Original Article Source Type: research

Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 May 20:159182. doi: 10.1016/j.bbalip.2022.159182. Online ahead of print.ABSTRACTHDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 and apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In add...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: F M Sacks J D Furtado M K Jensen Source Type: research

Neuroprotective Effect of Ischemic Preconditioning via Modulating the Expression of Adropin and Oxidative Markers against Transient Cerebral Ischemia in Diabetic Rats
Conclusion The study results supported the neuroprotective effects of ischemic preconditioning in MCA infarcts correlated with the level of oxidative damage markers and adropin.
Source: Peptides - March 25, 2016 Category: Biochemistry Source Type: research

Physiological and therapeutic effects of carnosine on cardiometabolic risk and disease.
Abstract Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnosine (β-alanyl-L-histidine) is a dipeptide with anti-inflammatory, antioxidant, anti-glycation, anti-ischaemic and chelating roles and is available as an over-the-counter food supplement. Animal evidence suggests that carnosine may offer many promising therapeutic benefits for multiple chroni...
Source: Amino Acids - March 16, 2016 Category: Biochemistry Authors: Baye E, Ukropcova B, Ukropec J, Hipkiss A, Aldini G, de Courten B Tags: Amino Acids Source Type: research

Utility of high density lipoprotein particle concentration in predicting future major adverse cardiovascular events among patients undergoing angiography.
CONCLUSION: In this study of patients undergoing angiography, HDL-P was a strong, independent predictor of future MACE, with the smaller HDL-P accounting for this association. PMID: 27616009 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - September 7, 2016 Category: Biochemistry Authors: May HT, Anderson JL, Winegar DA, Rollo J, Connelly MA, Otvos JD, Muhlestein JB Tags: Clin Biochem Source Type: research