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Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
In conclusion, our results showed that the pathophysiological factors in type 2 diabetes, including AGEs, were able to induce centrosome amplification. It is suggested that secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway which is upstream of ROCK1 and 14-3-3σ, which is the cell signaling pathway underlying the diabetes-associated centrosome amplification. PMID: 31618077 [PubMed - as supplied by publisher]
Source: Am J Physiol Cell Ph... - October 15, 2019 Category: Cytology Authors: He QJ, Wang P, Liu Q, Wu Q, Li YF, Wang J, Lee SC Tags: Am J Physiol Cell Physiol Source Type: research

IQGAP1 mediates podocyte injury in diabetic kidney disease by regulating nephrin endocytosis.
Abstract Diabetic kidney disease (DKD) is a complication associated with diabetes and is a major public health problem in modern society. Podocyte injury is the central target of the development of DKD, and the loss or dysregulation of nephrin, a key structural and signalling molecule located in the podocyte slit diaphragm (SD), initiates potentially catastrophic downstream events within podocytes. IQGAP1, a scaffold protein containing multiple protein-binding domains that regulates endocytosis, can interact with nephrin in podocytes. It is hypothesized that IQGAP1 contributes to nephrin endocytosis and may partic...
Source: Cellular Signalling - March 7, 2019 Category: Cytology Authors: Liu Y, Su H, Ma C, Ji D, Zheng X, Wang P, Zheng S, Wang L, Wang Z, Xu D Tags: Cell Signal Source Type: research

Tripterygium glycoside protects diabetic kidney disease mouse serum-induced podocyte injury by upregulating autophagy and downregulating β-arrestin-1.
CONCLUSIONS: This study demonstrated that tripterygium glycoside provided protection against podocyte injury induced by high-glucose serum, and that this effect was mediated by the concomitant activation of autophagy and downregulation of β-arrestin-1. PMID: 30839094 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - March 7, 2019 Category: Cytology Tags: Histol Histopathol Source Type: research

STIM promotes the epithelial-mesenchymal transition of podocytes through regulation of Fc γRII activity in diabetic nephropathy.
CONCLUSION: Our study suggests that STIM and FcγRII play an essential role in the regulation of DKD-induced podocyte EMT. STIM is an essential component of FcγR activation and inhibition of STIM-mediated signaling pathway might be a new strategy to treat IgG-dependent renal diseases. PMID: 30475382 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - November 28, 2018 Category: Cytology Tags: Histol Histopathol Source Type: research

The TRPC6-AMPK Pathway is Involved in Insulin-Dependent Cytoskeleton Reorganization and Glucose Uptake in Cultured Rat Podocytes
Conclusion: These results suggest a potentially important new mechanism that regulates glucose transport in podocytes and that could be injurious during diabetes.Cell Physiol Biochem 2018;51:393 –410
Source: Cellular Physiology and Biochemistry - November 19, 2018 Category: Cytology Source Type: research

Gp91 < sup > phox < /sup > (NOX < sub > 2 < /sub > ) in Activated Microglia Exacerbates Neuronal Damage Induced by Oxygen Glucose Deprivation and Hyperglycemia in an in Vitro Model
Conclusion: Knockdown of gp91phoxsiRNA significantly reduced oxidative stress and the inflammatory response, and alleviated neuronal damage after HG and OGD treatment in a rat neuronal-microglial co-culture model.Cell Physiol Biochem 2018;50:783 –797
Source: Cellular Physiology and Biochemistry - October 12, 2018 Category: Cytology Source Type: research

MicroRNA-141 Inhibits the Proliferation of Penile Cavernous Smooth Muscle Cells Associated with Down-Regulation of the Rhoa/Rho Kinase Signaling Pathway
Conclusion: Decreased expression of miR-141 is associated with up-regulation of RhoA and ROCK2 in the RhoA/ROCK signaling pathway in rats with diabetic erectile dysfunction. miR-141 inhibits the growth of penile cavernous smooth muscle cells associated with down-regulation of the RhoA/ROCK signaling pathwayin vitro.Cell Physiol Biochem 2018;48:348 –360
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research

Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF- κB/MAPK/ PI3K Signaling Systems
Conclusion: Collectively, our results show that palmitate induces CCL4 expression via activation of the TLR4-MyD88/NF-kB/MAPK/ PI3K signaling cascade. Thus, our findings suggest that the palmitate-induced CCL4 production might be an underlying mechanism of metabolic inflammation.Cell Physiol Biochem 2018;46:953 –964
Source: Cellular Physiology and Biochemistry - April 18, 2018 Category: Cytology Source Type: research

MiR-155 targets PTCH1 to mediate endothelial progenitor cell dysfunction caused by high glucose.
Abstract Endothelial progenitor cells (EPCs) are involved in diabetes-associated complications, including diabetic foot ulcer (DFU). Recent reports showed that miR-155 downregulation promotes wound healing in diabetic rats and ameliorates endothelial injury induced by high glucose, but its role in DFU is unknown. We found that miR-155 was overexpressed in EPCs from patients with DFU and in high glucose-induced EPCs from healthy people. Reductions in cell viability, migration, tube formation and nitric oxide production, as well as increases in lactated hydrogenase, cell apoptosis, and reactive oxygen species induce...
Source: Experimental Cell Research - March 12, 2018 Category: Cytology Authors: Gao J, Zhao G, Li W, Zhang J, Che Y, Song M, Gao S, Bin Zeng, Wang Y Tags: Exp Cell Res Source Type: research

Mdia1 is Crucial for Advanced Glycation End Product-Induced Endothelial Hyperpermeability
Conclusion: Our study revealed that mDia1 plays a critical role in AGE-induced microvascular hyperpermeability through binding to RAGE.Cell Physiol Biochem 2018;45:1717 –1730
Source: Cellular Physiology and Biochemistry - February 28, 2018 Category: Cytology Source Type: research

MicroRNA-27a Suppresses Detrusor Fibrosis in Streptozotocin-Induced Diabetic Rats by Targeting PRKAA2 Through the TGF- β1/Smad3 Signaling Pathway
Conclusion: These results indicate that miR-27a may contribute to detrusor fibrosis in STZ-induced diabetic rats by targeting PRKAA2 via the TGF- β1/Smad3 signaling pathway.Cell Physiol Biochem 2018;45:1333 –1349
Source: Cellular Physiology and Biochemistry - February 20, 2018 Category: Cytology Source Type: research

Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research

Cysteinyl leukotriene receptor 1 regulates glucose-stimulated insulin secretion (GSIS).
Abstract Insulin resistance is an important pathological hallmark of type 2 diabetes mellitus. Glucose-stimulated insulin secretion (GSIS) plays a key role in maintaining blood glucose levels within normal range. Impaired GSIS has been associated with type 2 diabetes, however, the underlying molecular mechanisms remain largely unknown. Cysteinyl leukotriene receptor 1 (cysLT1R) is an important G protein-coupled receptor mediating the biological functions of cysteinyl leukotrienes (cys-LTs). Little is known about the effects of cysLT1R in insulin secretion and pathogenesis of T2DM. In the present study, we aimed to...
Source: Cellular Signalling - February 2, 2018 Category: Cytology Authors: Guo R, Jiang J, Jing Z, Chen Y, Shi Z, Deng B Tags: Cell Signal Source Type: research

Protective Effects of Oxymatrine on Vascular Endothelial Cells from High-Glucose-Induced Cytotoxicity by Inhibiting the Expression of A < sub > 2B < /sub > Receptor
Conclusion: OMT may protect the HUVECs from high glucose-induced cytotoxicity through inhibitting the expression of A2B receptor and inflammatory factors as well as decreasing the phosphorylation of p38 and ERK1/2.Cell Physiol Biochem 2018;45:558 –571
Source: Cellular Physiology and Biochemistry - January 31, 2018 Category: Cytology Source Type: research

Synergistic effect of HIF ‐1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - October 14, 2017 Category: Cytology Authors: Ya ‐Fang Chen, Sudhir Pandey, Cecilia Hsuan Day, Yu‐Feng Chen, Ai‐Zhi Jiang, Tsung‐Jung Ho, Ray‐Jade Chen, Vijaya PadmaViswanadha, Wei‐Wen Kuo, Chih‐Yang Huang Tags: ORIGINAL RESEARCH ARTICLE Source Type: research

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