Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.

In conclusion, our results showed that the pathophysiological factors in type 2 diabetes, including AGEs, were able to induce centrosome amplification. It is suggested that secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway which is upstream of ROCK1 and 14-3-3σ, which is the cell signaling pathway underlying the diabetes-associated centrosome amplification. PMID: 31618077 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31618077?dopt=Abstract

Source: Am J Physiol Cell Ph... - October 15, 2019 Category: Cytology Authors: He QJ, Wang P, Liu Q, Wu Q, Li YF, Wang J, Lee SC Tags: Am J Physiol Cell Physiol Source Type: research