STIM promotes the epithelial-mesenchymal transition of podocytes through regulation of Fc γRII activity in diabetic nephropathy.

CONCLUSION: Our study suggests that STIM and FcγRII play an essential role in the regulation of DKD-induced podocyte EMT. STIM is an essential component of FcγR activation and inhibition of STIM-mediated signaling pathway might be a new strategy to treat IgG-dependent renal diseases. PMID: 30475382 [PubMed - as supplied by publisher]
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research