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Condition: Diabetes
Nutrition: Vitamins

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Total 20 results found since Jan 2013.

Vitamin D and its receptor regulate lipopolysaccharide‐induced transforming growth factor‐β, angiotensinogen expression and podocytes apoptosis via the nuclear factor‐κB pathway
ConclusionsVitamin D and its receptor may be involved in the progression of diabetic nephropathy by regulating transforming growth factor‐β, angiotensinogen expression and apoptosis of podocytes. The processes are mediated via the signaling of nuclear factor ‐κB pathway.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - January 1, 2016 Category: Endocrinology Authors: Lijuan Xu, Pengyuan Zhang, Hongyu Guan, Zhimin Huang, Xiaoying He, Xuesi Wan, Haipeng Xiao, Yanbing Li Tags: Original Article Source Type: research

Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran
AbstractIn 2018, patisiran was the first-ever RNA interference (RNAi)-based drug approved by the US Food and Drug Administration. Now pharmacology textbooks may include a new drug class that  results in the effect first described by Fire and Mello 2 decades ago: post-transcriptional gene silencing by a small-interfering RNA (siRNA). Patients with hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) present with mutations in the transthyretin (TTR) gene that lead to the formation of amyloid deposits in peripheral nerves and heart. The disease may also affect the eye and central nervous system. The formulatio...
Source: Molecular Diagnosis and Therapy - November 6, 2019 Category: Molecular Biology Source Type: research

Vitamin D and its receptor regulate lipopolysaccharide ‐induced transforming growth factor‐β, angiotensinogen expression and podocytes apoptosis through the nuclear factor‐κB pathway
ConclusionsVitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor‐β, angiotensinogen expression and apoptosis of podocytes. The processes are mediated through the signaling of nuclear factor‐κB pathway. Vitamin D and its receptor may be involved in the progression of diabetic nephropathy by regulating transforming growth factor‐β and angiotensinogen expression, and as well as the apoptosis of podocytes. The processes are mediated via the signaling of nuclear factor ‐κB pathway.
Source: Journal of Diabetes Investigation - March 31, 2016 Category: Endocrinology Authors: Lijuan Xu, Pengyuan Zhang, Hongyu Guan, Zhimin Huang, Xiaoying He, Xuesi Wan, Haipeng Xiao, Yanbing Li Tags: Original Article Source Type: research

Tanshinone IIA attenuates high glucose-induced epithelial-to-mesenchymal transition in HK-2 cells through VDR/Wnt/ β-catenin signaling pathway
CONCLUSIONS: TSIIA was able to attenuate high glucose-induced EMT in HK2 cells by up-regulating VDR levels, which might be related to the inhibitory effect of VDR on the Wnt pathway.PMID:34852178 | DOI:10.5603/FHC.a2021.0025
Source: Folia Histochemica et Cytobiologica - December 1, 2021 Category: Cytology Authors: Jingyi Zeng Xiaorong Bao Source Type: research

The Role of Maternal Gestational Diabetes in Inducing Fetal Endothelial Dysfunction
This study examines the effect of maternal diabetes on fetal endothelial function and gene expression under physiological glucose conditions (5mM). Human umbilical vein endothelial cell (HUVEC) isolated from diabetic mothers (d.HUVEC) grew more slowly than HUVEC isolated from healthy mothers (c.HUVEC) and had delayed doubling time despite increased levels of total vascular endothelial growth factor (VEGF) expression and protein production as determined by real time PCR and ELISA respectively. Using western blot, the levels of antiproliferative VEGF165b isoform were increased in d.HUVEC relative to c.HUVEC. Successful VEGF1...
Source: Journal of Cellular Physiology - March 24, 2015 Category: Cytology Authors: Samar A Sultan, Wanting Liu, Yonghong Peng, W. Roberts, Donald Whitelaw, Anne M Graham Tags: Original Research Article Source Type: research

Cystathionine-{gamma}-lyase Activity in Type 1 Diabetes Molecular Bases of Disease
This study investigated the activities of cystathionine-γ-lyase (CSE, the enzyme that catalyzes H2S formation) in livers of type 1 diabetic (T1D) animals and in peripheral blood mononuclear cells (PBMC) isolated from T1D patients. T1D is associated with both hyperketonemia (acetoacetate and β-hydroxybutyrate) and hyperglycemia. This study also examined the role of hyperglycemia and hyperketonemia per se in decreased CSE activity using U937 monocytes and PBMC isolated from healthy subjects. Livers from streptozotocin-treated T1D rats demonstrated a significantly higher reactive oxygen species production, lower CSE protein...
Source: Journal of Biological Chemistry - April 25, 2014 Category: Chemistry Authors: Manna, P., Gungor, N., McVie, R., Jain, S. K. Tags: Metabolism Source Type: research

Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats
This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration. We find that the expressions of TREM-1 and CD68 protein are higher in DN rats compared with rats in the normal control group and that these changes are decreased in the DN + VD group. In vitro, the capacity for macrophage adhesion and migration and the expression of TREM-1 are increased under high-glucose conditions, but VD inhibits this progress....
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Vitamin D protects glomerular mesangial cells from high glucose-induced injury by repressing JAK/STAT signaling
ConclusionVitamin D (VD) treatment inhibits the function of HG on fibronectin production through regulating JAK/STAT pathway. These results provide direct evidences that VD protects glomerular mesangial cells from high glucose-induced injury through repressing JAK/STAT signaling, which has the potential for clinical DN treatment.
Source: International Urology and Nephrology - May 3, 2021 Category: Urology & Nephrology Source Type: research