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Condition: Reflex Sympathetic Dystrophy
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Total 132 results found since Jan 2013.
Hypoxia-Inducible Factor-1 α (HIF-1α) Inhibition Impairs Retinoic Acid-Induced Differentiation in SH-SY5Y Neuroblastoma Cells, Leading to Reduced Neurite Length and Diminished Gene Expression Related to Cell Differentiation
Neurochem Res. 2021 Sep 23. doi: 10.1007/s11064-021-03454-3. Online ahead of print.ABSTRACTNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia-a common feature of the tumoural environment-is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aim...
Source: Neurochemical Research - September 24, 2021 Category: Neuroscience Authors: Pedro Ozorio Brum Guilherme Danielski Viola Carolina Saibro-Girardi Camila Tiefensee-Ribeiro Matheus Ozorio Brum Juciano Gasparotto Rachel Krolow Jos é Cláudio Fonseca Moreira Daniel Pens Gelain Source Type: research
Fine Tuning of Phosphorothioate Inclusion in 2 ′-O-Methyl Oligonucleotides Contributes to Specific Cell Targeting for Splice-Switching Modulation
Splice-switching antisense oligonucleotide- (SSO-) mediated correction of framedisrupting mutation-containing premessenger RNA (mRNA) transcripts using exon skipping is a highly promising treatment method for muscular diseases such as Duchenne muscular dystrophy (DMD). Phosphorothioate (PS) chemistry, a commonly used oligonucleotide modification, has been shown to increase the stability of and improve the pharmacokinetics of SSOs. However, the effect of PS inclusion in 2′-O-methyl SSOs (2OMe) on cellular uptake and splice switching is less well-understood. At present, we demonstrate that the modification of PS facilitate...
Source: Frontiers in Physiology - October 13, 2021 Category: Physiology Source Type: research
Sympathectomy decreases pain behaviors and nerve regeneration by downregulating monocyte chemokine CCL2 in dorsal root ganglia in the rat tibial nerve crush model
In this study, we examined the effect of a localized “microsympathectomy,” ie, cutting the gray rami containing sympathetic postganglionic axons where they enter the L4 and L5 spinal nerves, which is more analogous to clinically used sympathetic blockade compared with chemical or surgical sympathectomy. We also examined manipulations of CCL2 (monocyte chemoattractant protein 1), a key player in both regeneration and pain. We used rat tibial nerve crush as a neuropathic pain model in which peripheral nerve regeneration can occur successfully. CCL2 in the sensory ganglia was increased by tibial nerve crush and reduced by...
Source: Pain - December 27, 2021 Category: Anesthesiology Tags: Research Paper Source Type: research
Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition
In this study, we hypothesized that CAP regulates monocyte accessibility by influencing their adhesion to endothelial cells. Using RNA-seq analysis, we identified that α1,3-Fucosyltransferase 7 (FucT-VII), the enzyme required for processing selectin ligands, was significantly downregulated by α7nAChR agonist among other cell-cell adhesion genes. The α7nAChR agonist inhibited monocytic cell line U-937 binding to P-selectin and adhesion to endothelial cells. Furthermore, α7nAChR agonist selectivity was confirmed by α7nAChR knockdown assays, showing that FUT7 inhibition and adhesion attenuation by the agonist was abolish...
Source: Biochemical and Biophysical Research communications - January 1, 2022 Category: Biochemistry Authors: Chia-Hsien Wu Tsuyoshi Inoue Yasuna Nakamura Rie Uni Sho Hasegawa Hiroshi Maekawa Mai Sugahara Youichiro Wada Tetsuhiro Tanaka Masaomi Nangaku Reiko Inagi Source Type: research
Adeno-associated virus-mediated in vivo suppression of expression of EPHX2 gene modulates the activity of paraventricular nucleus neurons in spontaneously hypertensive rats
CONCLUSIONS: The elevation of EET levels by EPHX2 downregulation reduced presympathetic neuronal activity in the PVN of SHRs, leading to a reduced sympathetic outflow in hypertension rats. The ATP/SR/D-serine pathway of astrocytes is involved in EET-mediated neuroprotection.PMID:35344709 | DOI:10.1016/j.bbrc.2022.03.084
Source: Cell Research - March 28, 2022 Category: Cytology Authors: Xiaoming Zhu Kuibao Li Yuanfeng Gao Source Type: research
mTORC1 is a key regulator that mediates OGD- and TGF β1-induced myofibroblast transformation and chondroitin-4-sulfate expression in cardiac fibroblasts
Exp Ther Med. 2022 Jun;23(6):413. doi: 10.3892/etm.2022.11340. Epub 2022 Apr 27.ABSTRACTIschemia-reperfusion infarct-derived chondroitin sulfate proteoglycans (CSPGs) are important for sustaining denervation of the infarct. Sympathetic denervation within the heart after myocardial infarction (MI) predicts the probability of a higher risk for serious ventricular arrhythmias. Chondroitin-4-sulfate (C4S) is the predominant chondroitin sulfate component in the heart. However, the mechanisms that induce CSPG expression in fibroblasts following MI remain to be elucidated. The present study found that oxygen-glucose deprivation (...
Source: Experimental and Therapeutic Medicine - May 23, 2022 Category: General Medicine Authors: Chao Li Zheng Zhang Yu Peng Yanying Zhang Wanrong Kang Yingdong Li Yang Hai Source Type: research
SIRT1 exerts anti-hypertensive effect via FOXO1 activation in the rostral ventrolateral medulla
Free Radic Biol Med. 2022 Jun 7:S0891-5849(22)00223-4. doi: 10.1016/j.freeradbiomed.2022.06.003. Online ahead of print.ABSTRACTThe rostral ventrolateral medulla (RVLM) is a pivotal region in the central regulation of blood pressure (BP). It has been documented that silent information regulator 2 homolog 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent multifunctional transcription regulatory factor, has many cardiovascular protective effects. However, the role and significance of SIRT1 in the central regulation of cardiovascular activity, especially in RVLM, remains unknown. Therefore, the aim of this study ...
Source: Free Radical Biology and Medicine - June 10, 2022 Category: Biology Authors: Chang-Zhen Ren Zhao-Tang Wu Wen Wang Xing Tan Ya-Hong Yang Yang-Kai Wang Miao-Ling Li Wei-Zhong Wang Source Type: research
Post-Ganglionic Sympathetic Neurons can Directly Sense Raised Extracellular Na+ via SCN7a/Nax
The relationship between dietary NaCl intake and high blood pressure is well-established, and occurs primarily through activation of the sympathetic nervous system. Nax, a Na+-sensitive Na+ channel, plays a pivotal role in driving sympathetic excitability, which is thought to originate from central regions controlling neural outflow. We investigated whether post-ganglionic sympathetic neurons from different ganglia innervating cardiac and vasculature tissue can also directly sense extracellular Na+. Using whole-cell patch clamp recordings we demonstrate that sympathetic neurons from three sympathetic ganglia (superior cerv...
Source: Frontiers in Physiology - June 17, 2022 Category: Physiology Source Type: research
GSE161899 The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma siRNA_RRM2
In this study, we identified and functionally evaluated the ‘ribonucleotide reductase regulatory subunit 2’ (RRM2) as a top-ranked 2p putative co-driver and therapeutic target in high-risk neuroblastoma enforcing replicative stress resistance. RRM2 dependency was shown in vitro through knockdown in neuroblastoma cells, with transcriptome analysis reveali ng downregulation of pediatric tumor markers. Transgenic zebrafish lines expressing RRM2 in immature sympathoblasts were crossed with a dh-MYCN transgenic zebrafish line, with RRM2 overexpression dramatically increasing tumor penetrance from 20% to nearly 100%, acce...
Source: GEO: Gene Expression Omnibus - August 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
