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Munich atopy prediction study (MAPS): protocol for a prospective birth cohort addressing clinical and molecular risk factors for atopic dermatitis in early childhood
This study aims to comprehensively evaluate individual microbiome and immune responses in the context of environmental determinants related the risk of developing AD in the first 4 years of a child’s life. Methods and analyses The ‘Munich Atopic Prediction Study’ is a comprehensive clinical and biological investigation of a prospective birth cohort from Munich, Germany. Information on pregnancy, child development, environmental factors, parental exposures to potential allergens and acute or chronic diseases of children and parents are collected by questionnaires together with a meticulous clinical examin...
Source: BMJ Open - September 8, 2022 Category: General Medicine Authors: Preis, S., Schmidt, L., Tizek, L., Schielein, M., Lang, V., Bleuel, R., Duswald, A., Sitaru, S., Blasini, A., Gasteiger, C., Merdha, L., Kurgyis, Z., Kuschel, B., Hauenstein, E., Sander, M., Niedermeier, S., Argiriu, D., Engel, S., Skabytska, Y., Silva, R Tags: Open access, Dermatology Source Type: research

Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Infant formulas containing hydrolysed protein for prevention of allergic disease.
CONCLUSIONS: We found no evidence to support short-term or prolonged feeding with a hydrolysed formula compared with exclusive breast feeding for prevention of allergic disease. Very low-quality evidence indicates that short-term use of an EHF compared with a CMF may prevent infant CMA. Further trials are recommended before implementation of this practice.We found no evidence to support prolonged feeding with a hydrolysed formula compared with a CMF for prevention of allergic disease in infants unable to be exclusively breast fed. PMID: 30338526 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 19, 2018 Category: General Medicine Authors: Osborn DA, Sinn JK, Jones LJ Tags: Cochrane Database Syst Rev Source Type: research

Immunologic, microbial, and epithelial interactions in atopic dermatitis.
CONCLUSION: Recent clinical investigation has significantly expanded our knowledge on disease pathogenesis in atopic dermatitis, and current and future clinical trials will most likely further help to elucidate this complex, heterogeneous skin disease. PMID: 29126710 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - November 7, 2017 Category: Allergy & Immunology Authors: Brunner PM, Leung DYM, Guttman-Yassky E Tags: Ann Allergy Asthma Immunol Source Type: research

Atopic and vernal keratoconjunctivitis: differences and similarities
SummaryVernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) represents two severe forms of ocular allergies. In children both are rare diseases and may lead to visual impairment. VKC is a disease that affects primarily boys and children from 3 to 16 years old. Usually VKC disappears at adolescence. Photophobia and tearing are highly specific symptoms other than those usually observed in common ocular allergy as itching and grittiness. Two forms of the disease occur tarsal and limbal vernal keratoconjunctivitis. Tarsal form is marked by cobblestone papillae on the superior tarsal conjunctiva. Limbal form...
Source: Acta Ophthalmologica - September 13, 2016 Category: Opthalmology Authors: D. Bremond ‐Gignac Tags: Abstracts from the 2016 European Association for Vision and Eye Research Conference Source Type: research

WCD: Methotrexate found safer but less effective than cyclosporine in atopic dermatitis
VANCOUVER, B.C. – In the first head-to-head trial in atopic dermatitis, cyclosporine was about five times more effective in terms of SCORAD 50 but was associated with more adverse events, Dr. Catherine Goujon-Henry reported at the World Congress of Dermatology. Based on the findings,...googletag.display('div-gpt-ad-cta');
Source: Skin and Allergy News - June 27, 2015 Category: Dermatology Tags: SAN Conference News IMN Conferences SAN Atopic Dermatitis SAN Clinical News SAN News IMN News IMN Dermatology Source Type: news

Air Quality and Climate Change: A Delicate Balance
Background image: © Elenamiv/Shutterstock John H. Tibbetts, based in Charleston, SC, is former editor of Coastal Heritage, the magazine of the South Carolina Sea Grant Consortium. About This Article open Citation: Tibbetts JH. 2015. Air quality and climate change: a delicate balance. Environ Health Perspect 123:A148–A153; http://dx.doi.org/10.1289/ehp.123-A148 News Topics: Air Pollution, Allergies, Asthma, Cardiovascular Health, Climate Change, Combustion Emissions, Dust, Natural Disasters, Ozone, Particulate Matter (PM), Pollen, Mold and Mycotoxins, Respiratory Health, Temperature, Weather Processes Published: 1 Jun...
Source: EHP Research - June 1, 2015 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News Air Pollution Allergies Asthma Cardiovascular Health Climate Change Combustion Emissions Dust June 2015 Mold and Mycotoxins Natural Disasters Ozone Particulate Matter (PM) Pollen Respiratory Health Tem Source Type: research

Review of the 94th Annual Meeting of the British Association of Dermatologists, Glasgow 2014
Summary This is a review of the 94th Annual Meeting of the British Association of Dermatologists, held in Glasgow from 1 to 3 July 2014. The conference covered some of the latest developments in the treatment of atopic dermatitis, psoriasis and cancer, a follow‐up on the methylisothiazolinone contact allergy epidemic, advances in genetically inherited disorders and somatic mutations underlying birth marks. In addition, there was an international perspective on vitiligo, leprosy and HIV, and a session discussing the regulatory process behind pharmaceutical development.
Source: British Journal of Dermatology - May 11, 2015 Category: Dermatology Authors: R.M. Porter, S.M.C. George Tags: Meeting Report Source Type: research

Contact allergen of 2015: Formaldehyde
SAN FRANCISCO – Formaldehyde has been named the American Contact Dermatitis Society Contact Allergen of the Year for 2015, Dr. David E. Cohen said in the hot topics session at the annual meeting of the American Academy of Dermatology. Formaldehyde has been a factor in contact dermatitis for a...
Source: Skin and Allergy News - March 21, 2015 Category: Dermatology Tags: SAN Conference News SAN Clinical News SAN News SAN Atopic Dermatitis IMN News IMN Allergy & Immunology IMN Dermatology FPN News Source Type: news