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Role of heme oxygenases in cardiovascular syndromes and co-morbidities.
CONCLUSIONS: Each of the six major categories of CVD exhibit features of pathogenesis that hold potential as future therapeutic targets, for modulated heme oxygenase activity. PMID: 30051777 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - July 26, 2018 Category: Drugs & Pharmacology Authors: Haines DD, Tosaki A Tags: Curr Pharm Des Source Type: research

Adiponectin, lipids and atherosclerosis
Purpose of review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. Recent findings: This narrative review discusses the associations of adiponectin with obesity-...
Source: Current Opinion in Lipidology - July 14, 2017 Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research

A Review on Cellular and Molecular Mechanisms Linked to the Development of Diabetes Complications.
Abstract Modern lifestyle, changing eating habits and reduced physical work have been known to culminate into making diabetes a global pandemic. Hyperglycemia during the course of diabetes is an important causative factor for the development of both microvascular (retinopathy, nephropathy and neuropathy) and macrovascular (coronary artery disease, stroke and peripheral artery disease) complications. In this article, we summarize several mechanisms accountable for the development of both microvascular and macrovascular complications of diabetes. Several metabolic and cellular events are linked to the augmentation o...
Source: Current Diabetes Reviews - November 3, 2020 Category: Endocrinology Authors: Babel RA, Dandekar MP Tags: Curr Diabetes Rev Source Type: research

The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective
Diabetes has reached worldwide epidemic proportions, and threatens to be a significant economic burden to both patients and healthcare systems, and an important driver of cardiovascular mortality and morbidity. Improvement in lifestyle interventions (which includes increase in physical activity via exercise) can reduce diabetes and cardiovascular disease mortality and morbidity. Encouraging a population to increase physical activity and exercise is not a simple feat particularly in individuals with co-morbidities (obesity, heart disease, stroke, peripheral vascular disease, and those with cognitive and physical limitations...
Source: Frontiers in Physiology - February 23, 2021 Category: Physiology Source Type: research

Olive Oil Intake and Cardiovascular Disease Prevention: “Seek and You Shall Find”
AbstractPurpose of ReviewThe present narrative review focuses on the up-to-date clinical data on the correlations between olive oil consumption and cardiovascular (CV) diseases (i.e., CHD, stroke, and peripheral artery disease).Recent FindingsOlive oil contains monounsaturated fats, several antioxidant phenols, and other micronutrients that mediate CV-protective effects via improvements in oxidative stress, endothelial dysfunction, inflammation, thrombosis, blood pressure, and lipid and carbohydrate metabolism. High consumption of olive oil, and in particular the extra-virgin, which is rich in phenolic antioxidants, has be...
Source: Current Cardiology Reports - May 7, 2021 Category: Cardiology Source Type: research

Research Progress on Catalpol as Treatment for Atherosclerosis
Coronary atherosclerotic heart disease, cerebrovascular disease, and peripheral artery disease are common diseases with high morbidity and mortality rates and must be addressed. Their most frequent complications, including myocardial infarction and stroke, are caused by spontaneous thrombotic occlusion and are the most frequent cause of death worldwide. Atherosclerosis (AS) is the most widespread underlying pathological change for the above diseases. Therefore, drugs that interfere with this pathophysiological process must be incorporated in the treatment. Chinese traditional and herbal drugs can effectively treat AS. With...
Source: Frontiers in Pharmacology - July 13, 2021 Category: Drugs & Pharmacology Source Type: research

Therapeutic Effects of Resveratrol on Ischemia-Reperfusion Injury in the Nervous System
Neurochem Res. 2021 Aug 7. doi: 10.1007/s11064-021-03412-z. Online ahead of print.ABSTRACTResveratrol is a phenol compound produced by some plants in response to pathogens, infection, or physical injury. It is well-known that resveratrol has antioxidant and protective roles in damages potentially caused by cancer or other serious disorders. Thus, it is considered as a candidate agent for the prevention and treatment of human diseases. Evidence has confirmed other bioactive impacts of resveratrol, including cardioprotective, anti-tumorigenic, anti-inflammatory, phytoestrogenic, and neuroprotective effects. Ischemia-reperfus...
Source: Neurochemical Research - August 8, 2021 Category: Neuroscience Authors: Alireza Sarkaki Mojtaba Rashidi Mina Ranjbaran Aram Asareh Zadegan Dezfuli Zahra Shabaninejad Ebrahim Behzad Maryam Adelipour Source Type: research

Low serum albumin: A neglected predictor in patients with cardiovascular disease
Eur J Intern Med. 2022 May 7:S0953-6205(22)00181-9. doi: 10.1016/j.ejim.2022.05.004. Online ahead of print.ABSTRACTAlbumin, the most abundant circulating protein in blood, is an essential protein which binds and transports various drugs and substances, maintains the oncotic pressure of blood and influences the physiological function of the circulatory system. Albumin also has anti-inflammatory, antioxidant, and antithrombotic properties. Evidence supports albumin's role as a strong predictor of cardiovascular (CV) risk in several patient groups. Its protective role extends to those with coronary artery disease, heart failu...
Source: Atherosclerosis - May 10, 2022 Category: Cardiology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Dimitri P Mikhailidis Antonis S Manolis Source Type: research

Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease
Int J Mol Sci. 2023 Jun 9;24(12):9955. doi: 10.3390/ijms24129955.ABSTRACTPeripheral artery disease (PAD) affects more than 230 million people worldwide. PAD patients suffer from reduced quality of life and are at increased risk of vascular complications and all-cause mortality. Despite its prevalence, impact on quality of life and poor long-term clinical outcomes, PAD remains underdiagnosed and undertreated compared to myocardial infarction and stroke. PAD is due to a combination of macrovascular atherosclerosis and calcification, combined with microvascular rarefaction, leading to chronic peripheral ischemia. Novel therap...
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Cl émence Bechelli Diane Macabrey Sebastien Deglise Florent Allagnat Source Type: research