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Effects of GLP-1 receptor agonists on neurological complications of diabetes
Rev Endocr Metab Disord. 2023 May 26. doi: 10.1007/s11154-023-09807-3. Online ahead of print.ABSTRACTEmerging evidence suggests that treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) could be an interesting treatment strategy to reduce neurological complications such as stroke, cognitive impairment, and peripheral neuropathy. We performed a systematic review to examine the evidence concerning the effects of GLP-1 RAs on neurological complications of diabetes. The databases used were Pubmed, Scopus and Cochrane. We selected clinical trials which analysed the effect of GLP-1 RAs on stroke, cognitive impair...
Source: ENDOCR REV - May 25, 2023 Category: Endocrinology Authors: Natalia Garc ía-Casares Guillermo Gonz ález-González Carlos de la Cruz-Cosme Francisco J Garz ón-Maldonado Carmen de Rojas-Leal Mar ía J Ariza Manuel Narv áez Miguel Ángel Barbancho Juan Antonio Garc ía-Arnés Francisco J Tinahones Source Type: research

Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: analysis of ALTITUDE trial
Conclusions/interpretationWe identified three questions from the MNSI that provide additional prognostic information for individuals with type 2 diabetes and CKD and/or CVD. If externally validated, these questions may be integrated into the clinical history to augment prediction of CV events in high-risk individuals with type 2 diabetes.
Source: Diabetologia - November 3, 2017 Category: Endocrinology Source Type: research

Associations between complications and health‐related quality of life in individuals with diabetes
ConclusionsQuality of life in patients with diabetes is affected mainly by presence of complications, and not diabetes per se. Peripheral neuropathy was associated with the greatest reduction in quality of life. Improved management to prevent or delay onset of complications may reduce the effect on quality of life in patients with diabetes.
Source: Clinical Endocrinology - March 25, 2013 Category: Endocrinology Authors: K. Venkataraman, H. L. Wee, M. K. S. Leow, E. S. Tai, J. Lee, S. C. Lim, S. Tavintharan, T. Y. Wong, S. Ma, D. Heng, J. Thumboo Tags: Original Article Source Type: research

Differences between western and Asian type 2 diabetes patients in the incidence of vascular complications and mortality: A systematic review of randomized controlled trials on lowering blood glucose
ConclusionsCDVCs and mortality rates differ in western and Asian patients with advanced type 2 diabetes, differences mainly owing to ethnicity‐specific factors. Knowledge of these disparities may allow more effective monitoring and management of individual patients based on ethnic differences.
Source: Journal of Diabetes - December 11, 2015 Category: Endocrinology Authors: Jing Li, Yajie Dong, Taixiang Wu, Nanwei Tong Tags: Original Article Source Type: research

Microvascular disease and risk of cardiovascular events among individuals with type 2 diabetes: a population-level cohort study
Publication date: Available online 20 May 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Jack R W Brownrigg, Cian O Hughes, David Burleigh, Alan Karthikesalingam, Benjamin O Patterson, Peter J Holt, Matthew M Thompson, Simon de Lusignan, Kausik K Ray, Robert J Hinchliffe Background Diabetes confers a two times excess risk of cardiovascular disease, yet predicting individual risk remains challenging. The effect of total microvascular disease burden on cardiovascular disease risk among individuals with diabetes is unknown. Methods A population-based cohort of patients with type 2 diabetes fro...
Source: The Lancet Diabetes and Endocrinology - May 20, 2016 Category: Endocrinology Source Type: research

Absence of Peripheral Pulses and Risk of Major Vascular Outcomes in Patients With Type 2 Diabetes
CONCLUSIONS Absent dorsalis pedis and/or posterior tibial pulses are independent predictors of major vascular outcomes in patients with type 2 diabetes. These simple clinical indicators should be used to improve risk stratification and treatment of these patients.
Source: Diabetes Care - November 21, 2016 Category: Endocrinology Authors: Mohammedi, K.; Woodward, M.; Zoungas, S.; Li, Q.; Harrap, S.; Patel, A.; Marre, M.; Chalmers, J.; on behalf of the ADVANCE Collaborative Group Tags: Pathophysiology/Complications Source Type: research

Peripheral neuropathy as a complication of diabetic ketoacidosis in a child with newly diagnosed diabetes type 1 - case report.
CONCLUSIONS: Acute neuropathy after ketoacidosis is rare complication and its pathomechanism is not clear. Patients with DKA require careful monitoring of neurological functions even after normalization of glycemic parameters. PMID: 29217500 [PubMed - as supplied by publisher]
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - December 10, 2017 Category: Endocrinology Tags: J Clin Res Pediatr Endocrinol Source Type: research

Evaluation of health utility values for diabetic complications, treatment regimens, glycemic control and other subjective symptoms in diabetic patients using the EQ-5D-5L
ConclusionsThe utility decrement related to each diabetic complication varied with its severity and accompanying symptoms. Complex treatment regimens were independently associated with lower utility values. The utility decrement associated with diabetic complication and complex treatment regimens would be overestimated in the analysis without adjustment for glycemic control or other subjective symptoms.
Source: Acta Diabetologica - October 23, 2018 Category: Endocrinology Source Type: research

Prevalence of diabetic nephropathy among Chinese patients with type 2 diabetes mellitus and different categories of their estimated glomerular filtration rate based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation in primary care in Hong Kong: a cross-sectional study
ConclusionsDiabetic nephropathy was common among Chinese patients with type 2 diabetes in primary care in Hong Kong. Early identification and control of the modifiable risk factors are of upmost importance in preventing the complication.
Source: Journal of Diabetes and Metabolic Disorders - November 14, 2019 Category: Endocrinology Source Type: research

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