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Lactobacillus plantarum KLDS1.0318 Ameliorates Impaired Intestinal Immunity and Metabolic Disorders in Cyclophosphamide-Treated Mice
Conclusion In conclusion, the present study showed that the oral administration of L. plantarum KLDS1.0318 normalized the parameters altered by CTX-induced toxicities, strengthening intestinal health by regulating the Th1/Th2 balance, ameliorating the intestinal morphology and improving profiles of intestinal microbiota and metabolism. Therefore, our findings suggested that the administration of L. plantarum KLDS1.0318 could be of significant advantage in reducing intestinal immunity impairment caused by cyclophosphamide. Ethics Statement This study was carried out according to the Animal Care Review Committee, Northeas...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Local infiltration anaesthesia versus sciatic nerve and adductor canal block for fast-track knee arthroplasty: A randomised controlled clinical trial
BACKGROUND Local infiltration anaesthesia (LIA) was introduced as an innovative analgesic procedure for enhanced recovery after primary total knee arthroplasty (TKA). However, LIA has never been compared with analgesia based on an adductor canal catheter and a single-shot sciatic nerve block. OBJECTIVE To evaluate two analgesic regimens for TKA comparing mobility, postoperative pain and patient satisfaction. DESIGN Two-group randomised, controlled clinical trial. SETTING Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Germany between April and August 2017. PATIENTS Adults undergoing primary TKA u...
Source: European Journal of Anaesthesiology - March 4, 2019 Category: Anesthesiology Tags: Loco-regional anaesthesia Source Type: research

Epinephrine, auto-injectors and anaphylaxis: challenges of dose, depth and device.
CONCLUSION: EAIs should be available in the community with doses and needle depths that meet the needs of all patients. More research on epinephrine pharmacodynamics are needed in children and adults in anaphylaxis, in order to better delineate what optimal doses should be. Optimizing epinephrine dose and delivery has the potential to improve anaphylaxis outcomes and prevent adverse events. PMID: 29746901 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - May 7, 2018 Category: Allergy & Immunology Authors: Brown J Tags: Ann Allergy Asthma Immunol Source Type: research

Epinephrine auto-injector needle lengths can both subcutaneous and periosteal/intraosseous injection be avoided?
CONCLUSION: Common HPEAIs have a high risk of periosteal/intraosseous penetration in children and subcutaneous injections in overweight and obese adults. The LPEAIs have some risk of subcutaneous injection in adults. HPEAIs 0.1 mg epinephrine and shorter needle has no risk of periosteal/intraosseous injection but a high risk of subcutaneous deposit. For use in adult, over-weight/obese patients, HPEAIs and LPEAIs should have longer needles. Future studies should focus on the triggering pressures and the variations in needle length. PMID: 29499370 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - February 27, 2018 Category: Allergy & Immunology Authors: Dreborg S, Kim L, Tsai G, Kim H Tags: Ann Allergy Asthma Immunol Source Type: research

Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Conclusions: In the present study, we observed that early life exposure to PM2.5 may play an important role in the early life origins of COWO and may increase the risk of COWO in children of mothers who were overweight or obese before pregnancy beyond the risk that can be attributed to MPBMI alone. Our findings emphasize the clinical and public health policy relevance of early life PM2.5 exposure. https://doi.org/10.1289/EHP261 Received: 29 March 2016 Revised: 08 August 2016 Accepted: 23 August 2016 Published: 14 June 2017 Address correspondence to X. Wang, Center on the Early Life Origins of Disease, Department of P...
Source: EHP Research - June 14, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Magnetic resonance cholangiopancreatography uncovering massive gallbladder mucocele in a patient with ambiguous clinical and laboratory findings: a case report
Conclusion Magnetic resonance cholangiopancreatography should be considered as a complementary imaging modality to assess patients presenting with atypical biliary symptoms, particularly when ultrasound is equivocal or inconclusive, clinical and laboratory findings are non-specific, and computer tomography is contraindicated. Magnetic resonance cholangiopancreatography can also be considered in patients with acute cholecystitis not adherent to a specific severity grade.
Source: International Journal of Surgery Case Reports - May 20, 2017 Category: Surgery Source Type: research

Asthma-associated factors - Potential predictive markers for patients stratification, personalized treatments and prevention
Conclusion: Younger age, female gender; birth in January, April and July; appendectomy, tonsillectomy in anamnesis; allergy; obesity; physical and intellectual exertion, alcohol consumption, sauna, long stay in cold and damp room are relevant parameters, significantly associated with asthma, risk factors, affecting exacerbations.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Bubnov, R., Petrenko, L. Tags: 1.11 Clinical Problems - Asthma Source Type: research

Increased burden of inflammation over time is associated with the extent of atherosclerotic plaques in patients with psoriatic arthritis
Conclusions Exposure to an increased burden of inflammation is associated with more severe atherosclerosis in patients with PsA. This association may be mediated by traditional cardiovascular risk factors.
Source: Annals of the Rheumatic Diseases - September 9, 2015 Category: Rheumatology Authors: Eder, L., Thavaneswaran, A., Chandran, V., Cook, R., Gladman, D. D. Tags: Immunology (including allergy), Obesity (nutrition), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Excess subcutaneous tissue may preclude intramuscular delivery when using adrenaline autoinjectors in patients with anaphylaxis
Abstract Intramuscular adrenaline is the gold standard treatment for anaphylaxis. Intramuscular injection provides more rapid and higher plasma concentrations than subcutaneous routes. Given the increasing epidemic of obesity patients are at increased risk of subcutaneous delivery, we therefore assessed the depth of subcutaneous tissue in a population of patients with anaphylaxis. Patients already prescribed adrenaline autoinjectors (AAIs) for anaphylaxis were examined with ultrasound, and measurements of skin‐to‐muscle depth (STMD) at anterolateral thigh and anterior thigh were performed. Twenty‐eight patients (23 f...
Source: Allergy - March 29, 2015 Category: Allergy & Immunology Authors: J. Johnstone, S. Hobbins, D. Parekh, S. O'Hickey Tags: Brief Communication Source Type: research

Excess subcutaneous tissue may preclude intramuscular delivery when using epinephrine autoinjectors in patients with anaphylaxis
This article is protected by copyright. All rights reserved.
Source: Allergy - January 1, 2015 Category: Allergy & Immunology Authors: Jamie Johnstone, Stephanie Hobbins, Dhruv Parekh, Stephen O'Hickey Tags: Brief Communication Source Type: research