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Condition: Cirrhosis

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Total 302 results found since Jan 2013.

Smoking Causes More Kinds Of Deaths Than We Ever Thought
Breast cancer, prostate cancer, and even routine infections. A new report ties these and other maladies to smoking and says an additional 60,000 to 120,000 deaths each year in the United States are probably due to tobacco use. The study by the American Cancer Society and several universities, published in Thursday's New England Journal of Medicine, looks beyond lung cancer, heart disease and other conditions already tied to smoking, and the 480,000 U.S. deaths attributed to them each year. "Smokers die, on average, more than a decade before nonsmokers," and in the U.S., smoking accounts for one of every five deaths, Dr. ...
Source: Science - The Huffington Post - February 12, 2015 Category: Science Source Type: news

FloTrac® Monitoring System: What Are Its Uses in Critically Ill Medical Patients?
Abstract: The FloTrac®/Vigileo device uses arterial pressure waveform analysis to calculate stroke volume and cardiac output; it does not require calibration against an independent measurement of cardiac output. Consequently, it provides a method to determine hemodynamic status, changes in the clinical course and responses to therapeutic interventions in patients who have arterial catheters in place. These devices perform relatively well in stable patients undergoing surgery and having an acceptable percentage error in differences between the FloTrac® device and invasive monitoring using pulmonary catheters. However, in ...
Source: The American Journal of the Medical Sciences - March 31, 2015 Category: Journals (General) Tags: Review Article Source Type: research

Hypoglycemia in Emergency Department
Conclusions When hypoglycemic patients present in the emergency department, physicians should pay attention to the presence of infection, malignancy, liver diseases (liver cirrhosis and biliary tract infection), and acute renal failure.
Source: Journal of Acute Disease - April 22, 2015 Category: Emergency Medicine Source Type: research

Point-of-Care Echocardiography Improves Assessment of Volume Status in Cirrhosis and Hepatorenal Syndrome.
Abstract The management of cirrhotic patients with acute kidney injury is complex and depends in large part on accurate assessment of intravascular volume status. Assessments of intravascular volume status by point-of-care echocardiography often rely solely on inferior vena cava size/variability evaluation; however, this parameter should be intrepretated with an understanding of right ventricular function integrated with stroke volume/flow. Attempts to optimize intra-abdominal hemodynamics favorably are clearly problematic when physical examination findings or rudimentary assessments of central venous pressure or ...
Source: The American Journal of the Medical Sciences - April 17, 2015 Category: Journals (General) Authors: Huggins JT, Doelken P, Walters C, Rockey DC Tags: Am J Med Sci Source Type: research

Impact of Renal Impairment on Cardiovascular Disease Mortality After Liver Transplantation for Nonalcoholic Steatohepatitis Cirrhosis
ConclusionNASH recipients have an increased risk of CVD mortality after liver transplantation explained by a high prevalence of co‐morbid cardiometabolic risk factors that in aggregate identify those at highest risk of post‐transplant CVD mortality.This article is protected by copyright. All rights reserved.
Source: Liver International - May 15, 2015 Category: Gastroenterology Authors: Lisa B. VanWagner, Brittany Lapin, Anton I. Skaro, Donald M. Lloyd‐Jones, Mary E. Rinella Tags: Original Article Source Type: research

Medicinal uses, phytochemistry and pharmacology of the genus Uncaria
Conclusion Preliminary investigations on pharmacological properties of the Uncaria species have enlightened their efficacious remedy for hypertension, asthma, cancer, diabetes, rheumatism and neurodegenerative diseases. To ensure the safety and effectiveness in clinical application, research on bioactive compounds, pharmacological mechanisms and toxicity of the genus Uncaria as well as the stereo-chemistry and structure-activity relationships of indole alkaloids seem very important. Graphical abstract
Source: Journal of Ethnopharmacology - July 26, 2015 Category: Drugs & Pharmacology Source Type: research

Preexisting Diabetes and Risks of Morbidity and Mortality After Gastrectomy for Gastric Cancer: A Nationwide Database Study
Abstract: The purpose of this study was to determine the risk of surgical mortality and morbidity in patients with diabetes mellitus (DM) undergoing a gastrectomy for gastric cancer (GC). Using the Taiwan National Health Insurance Research Database, we identified 6284 patients who underwent gastrectomy for GC from 1999 to 2010. In addition, we created a non-DM control cohort consisting of 6268 patients who received gastrectomy during the same period. Compared with the non-DM cohort, the DM cohort exhibited a higher prevalence of preoperative coexisting medical conditions, namely hypertension, hyperlipidemia, coronary arter...
Source: Medicine - September 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Diabetes mellitus related biomarker: the predictive role of growth-differentiation factor-15
Publication date: Available online 9 October 2015 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Alexander E. Berezin Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine, which belongs to super family of the transforming growth factor beta. GDF-15 is widely presented in the various cells (macrophages, vascular smooth muscle cells, adipocytes, cardiomyocytes, endothelial cells, fibroblasts), tissues (adipose tissue, vessels, tissues of central and peripheral nervous system) and organs (heart, brain, liver, placenta) and it plays an important role in the ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - October 10, 2015 Category: Endocrinology Source Type: research

Cerebral air embolism during CT-guided lung biopsy
A patient with cirrhosis and hepatocellular carcinoma, on the waiting list for liver transplantation, presented with lung nodule during initial evaluation. A CT-guided core needle lung biopsy under general anaesthesia was performed. Pneumothorax (figure 1) and a large amount of gas within the left ventricle (figure 2) were identified during the procedure. Neurological focal signs (drowsiness, conjugate eye deviation and right hemiparesis) were observed in the anaesthesia-recovery period. A brain CT scan was immediately obtained, showing cerebral air embolism (figure 3). Initial resuscitation and hyperbaric oxygen therapy w...
Source: Thorax - October 14, 2015 Category: Respiratory Medicine Authors: Rocha, R. D., Azevedo, A. A., Falsarella, P. M., Rahal, A., Garcia, R. G. Tags: Images in Thorax, Journalology, Screening (oncology), Venous thromboembolism, Pulmonary embolism, Transplantation, Ethics Chest clinic Source Type: research

Prescription patterns of traditional Chinese medicine for peptic ulcer disease in Taiwan: A nationwide population-based study
Conclusions Our study identified the core prescription patterns of TCM for patients with peptic ulcer disease in Taiwan. Further basic and clinical studies are necessary to elucidate the efficacy and mechanisms. Graphical abstract
Source: Journal of Ethnopharmacology - November 18, 2015 Category: Drugs & Pharmacology Source Type: research

Donor risk factors in orthotopic liver transplant: analysis of the OPTN/UNOS registry.
This study of the United Network for Organ Sharing registry data analyzed reputed donor factors using the post-MELD data and evaluated them further in HCV positive and HCV negative recipients with hepatic cirrhosis to develop a modified DRI (mDRI). We found that HCV negative cirrhotic recipients have generally higher tolerance against inferior qualities of donors than HCV positive cirrhotic patients. In addition, the results revealed the post-MELD prognostic factors that should be considered in the donor procurement processes. The group of "all recipients" and the subset of HCV positive cirrhotic recipients showed a simila...
Source: Clinical Transplants - November 20, 2015 Category: Transplant Surgery Tags: Clin Transpl Source Type: research

Frequency of Cardiovascular Events and Effect on Survival in Liver Transplant Recipients for Cirrhosis Due to Alcoholic or Nonalcoholic Steatohepatitis.
CONCLUSIONS: Cardiovascular events occurred with similar frequency in transplant recipients for nonalcoholic steatohepatitis or alcoholic cirrhosis. Patient survival was affected in both groups, but male patients with concomitant hepatitis C virus infection remained at higher risk for a cardiovascular event after liver transplant. Development of a cardiac evaluation protocol for liver transplant recipients could help monitor these patients. PMID: 26581602 [PubMed - as supplied by publisher]
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - November 17, 2015 Category: Transplant Surgery Authors: Piazza NA, Singal AK Tags: Exp Clin Transplant Source Type: research

Relation Between Hepatitis C Virus Exposure and Risk of Osteoporosis: A Nationwide Population-Based Study
Abstract: The effect of hepatitis C virus (HCV) exposure on bone mineral density without advanced liver disease remains debated. Thus, we assessed the relation between HCV exposure and the risk of osteoporosis. From 2000 to 2011, patients aged>20 years with HCV exposure were identified from the Longitudinal Health Insurance Database 2000. Of the 51,535 sampled patients, 41,228 and 10,307 patients were categorized as the comparison and the HCV exposure cohorts, respectively. The overall incidence of osteoporosis in the HCV exposure cohort was higher than in the comparison cohort (8.27 vs 6.19 per 1000 person-years; crude ha...
Source: Medicine - November 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The role of copeptin in patients with subarachnoid haemorrage.
CONCLUSION: Patients with a gradual increase of copeptin values showed to have bad prognosis of the disease. Four with extremely high copeptin values passed away, while patients with a gradual decrease or a normal amount of copeptin values had good prognosis. It is supported that copeptin values are a reliable prognostic factor in monitoring patients with intracranial haemorrhage. PMID: 26665233 [PubMed - as supplied by publisher]
Source: Hellenic Journal of Nuclear Medicine - December 17, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research

Biomarker value and pitfalls of serum S100B in the follow‐up of high‐risk melanoma patients
ConclusionsSerum S100B is a useful quantitative biomarker in routine follow‐up of high‐risk melanoma patients. While false‐negative results are frequent in patients with low tumor load, false‐positive results are associated with several comorbid diseases and warrant careful reevaluation.
Source: JDDG - January 27, 2016 Category: Dermatology Authors: Christoffer Gebhardt, Ramtin Lichtenberger, Jochen Utikal Tags: Original Article Source Type: research