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Total 29 results found since Jan 2013.

Metformin reverses oxidative stress ‑induced mitochondrial dysfunction in pre‑osteoblasts via the EGFR/GSK‑3β/calcium pathway
Int J Mol Med. 2023 Apr;51(4):36. doi: 10.3892/ijmm.2023.5239. Epub 2023 Mar 31.ABSTRACTOxidative stress is one of the main causes of osteoblast apoptosis induced by post‑menopausal osteoporosis. The authors previously found that metformin can reverse the loss of bone mass in post‑menopausal osteoporosis. The present study aimed to further clarify the effects and mechanisms of action of metformin in post‑menopausal osteoporosis under conditions of oxidative stress. Combined with an in‑depth investigation using the transcriptome database, the association between oxidative stress and mitochondrial dysfunction in post...
Source: International Journal of Molecular Medicine - March 31, 2023 Category: Molecular Biology Authors: Fangming Cao Keda Yang Shui Qiu Jie Li Wen Jiang Lin Tao Yue Zhu Source Type: research

MiR-196a-5p facilitates progression of estrogen-dependent endometrial cancer by regulating FOXO1
CONCLUSIONS: Our findings suggested potential diagnostic and therapeutic applications for miR-196a-5p and its FOXO1 target in patients suffering from estrogen-dependent endometrial cancer.PMID:36573636 | DOI:10.14670/HH-18-572
Source: Histology and Histopathology - December 27, 2022 Category: Cytology Authors: Yuzhang Zhu Yanfei Tang Yaohua Fan Dongjuan Wu Source Type: research

Liuwei Dihuang soft capsules inhibits the phenotypic conversion of VSMC to prevent the menopausal atherosclerosis by up-regulating the expression of myocardin
ConclusionsLWDH could inhibit the phenotypic conversion of VSMCs in vitro and in vivo by increasing the activity of myocardin through up-regulating the expression of ERα and promoting the interaction between ERα and SRC3. Our research reveals the under mechanism of how LWDH inhibits the phenotypic conversion of VSMCs.Graphical abstract
Source: Journal of Ethnopharmacology - August 31, 2019 Category: Drugs & Pharmacology Source Type: research

The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype.
CONCLUSION: We confirm previous studies showing that the PTPN2 protein is lost in half of the breast cancer cases and gene deletion occurs in 15-18% of the cases. Furthermore, the results suggest that the role of PTPN2 is subtype-related and should be further investigated to assess how this could affect breast cancer prognosis and treatment response. PMID: 31025094 [PubMed - indexed for MEDLINE]
Source: Clinical Breast Cancer - June 30, 2019 Category: Cancer & Oncology Authors: Veenstra C, Karlsson E, Mirwani SM, Nordenskjöld B, Fornander T, Pérez-Tenorio G, Stål O Tags: J Cancer Res Clin Oncol Source Type: research

The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype
ConclusionWe confirm previous studies showing that the PTPN2 protein is lost in half of the breast cancer cases and gene deletion occurs in 15 –18% of the cases. Furthermore, the results suggest that the role of PTPN2 is subtype-related and should be further investigated to assess how this could affect breast cancer prognosis and treatment response.
Source: Journal of Cancer Research and Clinical Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research

Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin
Conclusion: Our results provide novel evidence that HDGF interacts with DDX5 and promotes the progression of EC through the induction of β-catenin. Introduction Endometrial cancer (EC) comprises the most common malignancy involving the female genital tract and the fourth most common malignancy in women after breast, lung, and colorectal cancers (1). In 2012, approximately 320,000 new cases of EC were diagnosed worldwide and the incidence is increasing (2). Currently, endometrial carcinogenesis is thought to be a multi-step process involving the coordinated interaction of hormonal regulation, gene mutation, ad...
Source: Frontiers in Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

Activation of Estrogen Receptor Alpha Induces Beiging of Adipocytes
ConclusionOur results demonstrate for the first time that selective-activation of ERα in adipocytes increases markers of beiging and this is likely through induction of AMPK and ATGL-mediated lipolysis providing FFAs as a fuel to activate UCP-1.
Source: Molecular Metabolism - September 16, 2018 Category: Endocrinology Source Type: research