The effects of PTPN2 loss on cell signalling and clinical outcome in relation to breast cancer subtype

ConclusionWe confirm previous studies showing that the PTPN2 protein is lost in half of the breast cancer cases and gene deletion occurs in 15 –18% of the cases. Furthermore, the results suggest that the role of PTPN2 is subtype-related and should be further investigated to assess how this could affect breast cancer prognosis and treatment response.

http://link.springer.com/10.1007/s00432-019-02918-y

Source: Journal of Cancer Research and Clinical Oncology - June 15, 2019 Category: Cancer & Oncology Source Type: research