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Drug: Estradiol

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Total 380 results found since Jan 2013.

Effects of exposure to the explosive and environmental pollutant 2,4,6-trinitrotoluene on ovarian follicle development in rats
Environ Sci Pollut Res Int. 2023 Aug 12. doi: 10.1007/s11356-023-29161-w. Online ahead of print.ABSTRACTAlthough 2,4,6-trinitrotoluene (TNT) is a dangerous carcinogen in environmental pollution, information on the reproductive effects of TNT explosive contamination is limited. To explore the possible ovarian effects, TNT explosive-exposed rat models were established, and Wistar female rats were exposed to low and high TNT (40 g and 80 g, air and internal) explosives. After a month of exposure, the estrous cycle, ovarian histopathology, and follicle counting were conducted. Serum hormones follicle-stimulating hormone (FSH),...
Source: Environmental Science and Pollution Research International - August 11, 2023 Category: Environmental Health Authors: Dai Lin Yiqin Chen Lisheng Liang Zuxiong Huang Yiwei Guo Ping Cai Wenxiang Wang Source Type: research

Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition
This study suggests that immediate HRT after menopause, along with appropriate iron chelation, might provide benefits from AS.PMID:37561022 | PMC:PMC10414966 | DOI:10.7554/eLife.80494
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: Tianze Xu Jing Cai Lei Wang Li Xu Hongting Zhao Fudi Wang Esther G Meyron-Holtz Fanis Missirlis Tong Qiao Kuanyu Li Source Type: research

Cyhexatin causes developmental toxic effects by disrupting endocrine system and inducing behavioral inhibition, apoptosis and DNA hypomethylation in zebrafish (Danio rerio) larvae
In this study, zebrafish embryos were firstly exposed to CYT (0.06, 0.12, and 0.20 ng/mL, referred to as CYTL, CYTM, and CYTH, respectively) from 2 hpf (hours post fertilization) to 30 dpf (days post fertilization). No developmental toxicity was observed in the CYTL and CYTM groups, except for induced deformed phenotypes in the CYTM group at 120 hpf. However, exposure to CYTH resulted in significant reductions in spontaneous movement (24 hpf), heart rate (48 hpf), hatching rate (48 and 72 hpf), body weight (30 dpf), whole body length (30 dpf), and locomotion (30 dpf). Additionally, CYTH exposure induced morphological malfo...
Source: Chemosphere - August 10, 2023 Category: Chemistry Authors: Fang Jiao Yang Zhao Samwel Mchele Limbu Lingfu Kong Daitao Zhang Xianghe Liu Sha Yang Wenjun Gui Hua Rong Source Type: research

Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo. « Back to Top Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/ It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice
In this study, 1 mg/kg of cadmium chloride (CdCl2) was injected intraperitoneally every other day in 8-week-old C57BL/6 J male mice to study the effects on their female offspring. Our results showed an increase in body weight, water intake and food intake in F1 female mice from the Cd-exposed group. The development of secondary follicles and antral follicles in the ovaries of Cd-treated was inhibited. Serum estradiol (E2) was found to be decreased. Further analysis revealed significant downregulation of StAR, P450scc, 17β-HSD, CYP17A1 and CYP19A1, which are related to E2 synthesis. Serum total cholesterol was increased an...
Source: Ecotoxicology and Environmental Safety - July 23, 2023 Category: Environmental Health Authors: Yanwei Zhang Jinzhao Zhou Ling Zeng Yifan Xiong Xiaofei Wang Wenpei Xiang Ping Su Source Type: research

Organophosphate Esters Disrupt Steroidogenesis in KGN Human Ovarian Granulosa Cells
Endocrinology. 2023 Jun 8:bqad089. doi: 10.1210/endocr/bqad089. Online ahead of print.ABSTRACTOrganophosphate esters (OPEs) are used extensively as flame retardants and plasticizers and are found ubiquitously in the environment and human matrices. Previous studies suggested that exposure to some of these chemicals may disrupt the homeostasis of female sex hormones and have detrimental effects on female fertility. Here, we determined the effects of OPEs on the function of KGN ovarian granulosa cells. We hypothesized that OPEs alter the steroidogenic ability of these cells by dysregulating the expression of transcripts invol...
Source: Endocrinology - June 8, 2023 Category: Endocrinology Authors: Xiaotong Wang Elaine Lee Barbara F Hales Bernard Robaire Source Type: research

Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies
Nutr Cancer. 2023 May 31:1-21. doi: 10.1080/01635581.2023.2219027. Online ahead of print.ABSTRACTAmong luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening found pelargonidin (PG) can inhibit ER-signaling with potent bioactivity and satisfactory toxicological features. The present study explored the anti-tumoral prospect of PG against DMBA-induced ER + murine mammary carcinogenesis. The female BALB/c mice were divided into control...
Source: Nutrition and Cancer - May 31, 2023 Category: Cancer & Oncology Authors: Yahyea Baktiar Laskar Kasturi Bhattacharjee Moumita Nath Yashmin Choudhury Pranab Behari Mazumder Anupam Das Talukdar Source Type: research