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Total 407 results found since Jan 2013.

Complications of Cushing's syndrome: state of the art
Publication date: Available online 10 May 2016 Source:The Lancet Diabetes & Endocrinology Author(s): Rosario Pivonello, Andrea M Isidori, Maria Cristina De Martino, John Newell-Price, Beverly M K Biller, Annamaria Colao Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities. These clinical complications include metabolic syndrome, consisting of systemic arterial hypertension, visceral obesity, impairment of glucose metaboli...
Source: The Lancet Diabetes and Endocrinology - May 11, 2016 Category: Endocrinology Source Type: research

Bipolar disorder, ischemic stroke, mitral valve vegetation and recurrent venous thrombosis due to antiphospholipid syndrome despite rivaroxaban
Antiphospholipid syndrome(APS) is an autoimmune disorder. The diagnostic criteria comprise clinical criteria - vascular thrombosis or pregnancy morbidity - together with laboratory criterion: lupus anticoagulant, anticardiolipin(aCL) antibody of immunoglobulin(Ig)G/IgM isotype or anti-β2-glycoprotein-I antibody of IgG/M isotype [1].
Source: International Journal of Cardiology - June 22, 2016 Category: Cardiology Authors: Jennifer Rokos, Maria Heger, Claudia Stöllberger, Josef Finsterer, Günther Laufer, Dominik Wiedemann Source Type: research

Post-stroke emotional incontinence or bipolar disorder?
Source: Neuropsychiatric Disease and Treatment - July 28, 2016 Category: Psychiatry Tags: Neuropsychiatric Disease and Treatment Source Type: research

Mental Illness Affects Presidents, Too
Perhaps it isn’t surprising, given the intense rhetoric of this year’s presidential election, that politicians have started throwing around accusations of insanity.    In early August, California Rep. Karen Bass, a Democrat, launched the hashtag #DiagnoseTrump and started a change.org petition claiming the Republican nominee, Donald Trump, meets the diagnostic criteria for Narcissistic Personality Disorder. Not long after, Trump called Hillary Clinton “unstable,” and at a rally in New Hampshire said, “She’s got problems.” The candidates’ verbal volley highlights a p...
Source: Healthy Living - The Huffington Post - August 17, 2016 Category: Consumer Health News Source Type: news

MRI scan may help diagnose chronic traumatic encephalopathy, UCLA researchers report
UCLA doctors have found what may be an earlier and easier way to diagnose chronic traumatic encephalopathy, or CTE, a disorder that is thought to affect some former football players and others with a history of repetitive brain trauma. Using a new software tool for analyzing MRI scans, the researchers detected the shrinkage of several key brain regions in a former football player with cognitive problems. The same pattern of brain changes is commonly seen in CTE cases that have been confirmed by autopsies after a person’s death. While the findings from this single case report are preliminary, they raise the possibility th...
Source: UCLA Newsroom: Health Sciences - August 24, 2016 Category: Universities & Medical Training Source Type: news

Hillary Clinton's New Platform Is A Blow To Mental Health Stigma
Democratic presidential nominee Hillary Clinton released a wide-ranging mental health plan on Monday, saying that her office would support Americans living with mental health issues through better legislation. “The next generation must grow up knowing that mental health is a key component of overall health and there is no shame, stigma or barriers to seeking out care,” Clinton’s campaign stressed in an announcement. Of course, candidate platforms rarely remain intact if they actually become policy after election day, but Clinton’s focus on normalizing mental health treatment reflects growi...
Source: Science - The Huffington Post - August 30, 2016 Category: Science Source Type: news

'Non-criteria' neurologic manifestations of antiphospholipid syndrome: A hidden kingdom to be discovered.
Abstract Neurological manifestations or disorders associated with central nervous system (CNS) are one of the most common as well as important clinical characteristics of antiphospholipid syndrome (APS). Although in the last updated (2006) classification criteria of APS its neurological manifestations encompassed only transient ischemic attack (TIA) and stroke, diverse 'non-criteria' neurological disorders or manifestations (headache, migraine, bipolar disorder, transverse myelitis, dementia, chorea, epileptic seizures, multiple sclerosis, psychosis, cognitive impairment, Tourette's syndrome, parkinsonism, dystoni...
Source: CNS and Neurological Disorders Drug Targets - September 19, 2016 Category: Drugs & Pharmacology Authors: Islam MA, Alam F, Kamal MA, Wong KK, Sasongko TH, Gan SH Tags: CNS Neurol Disord Drug Targets Source Type: research

Increased risk of Parkinson disease with diabetes mellitus in a population-based study
Abstract: This nationwide population-based study investigated the risk of Parkinson disease (PD) in relation to diabetes mellitus (DM) through the National Health Insurance Research Database in Taiwan. A retrospective study was conducted, consisting of 36,294 patients who were newly diagnosed with DM between January 1, 2000 and December 31, 2006 and 108,882 individuals without DM as healthy controls from insurance claims data from Taiwan's National Health Research Institutes Dataset. The subjects were followed up until December 31, 2011 or until the first manifestation of PD. The hazard ratio (HR) of DM for PD incidence w...
Source: Medicine - January 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Clinical Reasoning: A young woman with respiratory failure, hearing loss, and paraplegia
A 35-year-old woman with bipolar disorder presented to the emergency room (ER) obtunded with hypercapnic respiratory failure. Neurology was consulted because the patient had acute hearing loss and paraparesis. She was last seen normal the prior night by her ex-husband. Paramedics found her on the couch, obtunded, bradypneic, and hypoxic to 82% SpO2, blood pressure 116/79 mm Hg, heart rate 98 beats per minute, and normothermic. She awakened after 0.4 mg of naloxone administration. Home medications included oxycodone/acetaminophen for chronic pain and venlafaxine, alprazolam, and lamotrigine for bipolar disorder. O...
Source: Neurology - March 5, 2017 Category: Neurology Authors: Ntranos, A., Shoirah, H., Dhamoon, M. S., Hahn, D., Naidich, T. P., Shin, S. Tags: Stroke in young adults, MRI, Spinal cord infarction, Opiates, Infarction RESIDENT AND FELLOW SECTION Source Type: research

Statin prescribing for people with severe mental illnesses: a staggered cohort study of 'real-world impacts
Conclusions We found that statin prescribing to people with SMI in UK primary care was effective for lipid modification but not CVD events. The latter finding may reflect insufficient power to detect a smaller effect size than that observed in randomised controlled trials of statins in people without SMI.
Source: BMJ Open - March 6, 2017 Category: Journals (General) Authors: Blackburn, R., Osborn, D., Walters, K., Falcaro, M., Nazareth, I., Petersen, I. Tags: Open access, Cardiovascular medicine, Epidemiology, General practice / Family practice, Mental health Research Source Type: research

CNS Summit 2016 Abstracts of Poster Presentations
Conclusion: Subjects with acutely exacerbated schizophrenia who were eligible for discharge from the inpatient setting and who completed the study demonstrated high rates of adherence using the mobile AI application. Subjects were able to easily use the technology. Use of the platform did not appear to increase the dropout rate. This study demonstrates the feasibility of using AI platforms to ensure high adherence, provide reliable adherence data, and rapidly detect nonadherence in CNS trials. Disclosures/funding: Adam Hanina and Laura Shafner are employees of AiCure, New York, New York, and consultants to Takeda. Xinxin D...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Devices Drug Development Evaluations Genetics Medical Issues Neurology Patient Assessment Proceedings Psychiatry Psychopharmacology Scales Supplements Technology Trial M Source Type: research

Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.
Abstract People with severe mental illness (SMI) - schizophrenia, bipolar disorder and major depressive disorder - appear at risk for cardiovascular disease (CVD), but a comprehensive meta-analysis is lacking. We conducted a large-scale meta-analysis assessing the prevalence and incidence of CVD; coronary heart disease; stroke, transient ischemic attack or cerebrovascular disease; congestive heart failure; peripheral vascular disease; and CVD-related death in SMI patients (N=3,211,768) versus controls (N=113,383,368) (92 studies). The pooled CVD prevalence in SMI patients (mean age 50 years) was 9.9% (95% CI: 7.4-...
Source: World Psychiatry - May 13, 2017 Category: Psychiatry Authors: Correll CU, Solmi M, Veronese N, Bortolato B, Rosson S, Santonastaso P, Thapa-Chhetri N, Fornaro M, Gallicchio D, Collantoni E, Pigato G, Favaro A, Monaco F, Kohler C, Vancampfort D, Ward PB, Gaughran F, Carvalho AF, Stubbs B Tags: World Psychiatry Source Type: research

Chris Cornell: When Suicide Doesn't Make Sense
By Julie A. Fast Sometimes, people commit suicide and it does make some sense. It’s scary and upsets our world, but on a basic level we think we understand. The suicide of Robin Williams comes to mind. He had a history of depression and his health was failing. Oh how we all wish he could have found more help, but I don’t think it was as much surprising as it was devastating and sad for the millions who loved him when he died. Then there are suicides that make no sense. They don’t fit in the current life of the person or fit what the person is actually saying about life in public. The partner or other love...
Source: Healthy Living - The Huffington Post - May 18, 2017 Category: Consumer Health News Source Type: news

Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature
AbstractThis was a study of a 33-year-old man with bipolar disorder treated with lithium who developed cerebellar atrophy after an event of extreme hyperthermia. Unlike previously reported cases of acute cerebellar atrophy after heat stroke, neuroleptic syndrome or lithium toxicity, this case was characterized by a chronic cerebellar atrophy that developed after sepsis-induced hyperthermia in the setting of non-toxic lithium levels. Unique to this case also was the early finding of cerebellar atrophy on MRI 2  weeks after the episode of hyperthermia, long-term neurotoxicity after the novo lithium therapy, and longest foll...
Source: The Cerebellum - June 8, 2017 Category: Neurology Source Type: research