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Total 26 results found since Jan 2013.

Inflammation-Related circRNA Polymorphism and Ischemic Stroke Prognosis
AbstractCircRNAs belong to a novel class of noncoding RNAs that are generated by exons of genes by alternative mRNA splicing and involved in pathophysiological processes of ischemic stroke by regulating neuro-inflammation. A total of 982 patients were enrolled in our study for stroke recovery analysis. The aim of our study was to first explore the association between the inflammation-related circRNA polymorphism and functional outcome 3  months after ischemic stroke by using multivariate logistic regression model. Next, we further investigated the role of circRNA polymorphism in predicting stroke recurrence by using Cox p...
Source: Journal of Molecular Neuroscience - July 17, 2021 Category: Neuroscience Source Type: research

An itch you just can’t scratch
Everyone knows the best way to suppress an itch is to scratch it, but for people who suffer from skin diseases like eczema, no amount of scratching can bring relief. Fortunately, help may be on the way. Scientists from the Buck Institute for Research on Aging and the University of California, Berkeley have identified a pair of proteins responsible for chronic itching. The study, published in Neuron and partially funded by the NIH’s National Institute of Neurological Disorders and Stroke (NINDS), may lead to treatments that can stop an itch at its source.
Source: NINDS Press Releases and News: National Institute of Neurological Disorders and Stroke - October 27, 2015 Category: Neurology Source Type: news

What You Should Know Before You Schedule Your Next Doctor Appointment
Before we were able to Google our every itch and twinge and ache, we had very different relationships with our doctors. “In the early years of my career, information was something the doctor had and the patient didn’t,” Dr. Michael L. LeFevre, a professor and physician at the University of Missouri, tells The Huffington Post. Today, he says, patients bring their information to him for his input. “They want my opinion about how good the information is and what it means and how to interpret it for them in their lives.” Of course, the Internet is rife with misinformation, and sometimes a well-meaning patient will ...
Source: Healthy Living - The Huffington Post - February 10, 2015 Category: Consumer Health News Source Type: news

Every Little Anniversary
One of the things they tell you after they’ve informed you that you have cancer or that you’ve had a stroke—after they tell you about the resections and the radiation—after they tell you about the aspirin and the clopidogrel—after you’re stable medically but still more than a little unstable emotionally—is to look for a support group. I had the kind of cancer that you learn about in medical school and then never see. I was decades younger than most of my physicians’ patients with stroke. The local support groups didn’t seem to fit me. I looked online at first, but then—even though I found a few people w...
Source: JAMA - December 1, 2015 Category: Journals (General) Source Type: research

7 Foot Problems That Can Be Serious
If you want to know the state of your health, try looking down. “There’s no question it’s extremely important that people pay attention to their feet,” says Terry Philbin, D.O., spokesperson for the American Academy of Orthopedic Surgeons (AAOS) and a foot and ankle specialist at the Orthopedic Foot and Ankle Center in Westerville, Ohio. The condition of your feet can give you clues to a host of medical issues, such as diabetes, arthritis, and even heart disease. Read on to find out what to look for and what it may mean. 1. Pain “There’s no pain that should be ignored,” says Jane ...
Source: Healthy Living - The Huffington Post - November 12, 2016 Category: Consumer Health News Source Type: news

Blame These Bumps on Mosquitoes?
Multiple itchy red bumps on a man’s ankles; relative contraindications to lumbar puncture; stroke in an addict. . . 5 more questions for you to test the breadth of your clinical knowledge.
Source: Consultant Live - September 26, 2013 Category: Primary Care Source Type: news

Lab Notes: Red Wine Good for Cancer, Too?
(MedPage Today) -- The red wine compound resveratrol, once inside cells, appears to slow their division. Also this week, electrical stimulation for stroke recovery and scratching the eczema itch.
Source: MedPage Today State Required CME - October 5, 2013 Category: Consumer Health News Source Type: news

The neurology of itch
Research over the past 15 years has helped to clarify the anatomy and physiology of itch, the clinical features of neuropathic itch syndromes and the scientific underpinning of effective treatments. Two itch-sensitive pathways exist: a histamine-stimulated pathway that uses mechanically insensitive C-fibres, and a cowhage-stimulated pathway primarily involving polymodal C-fibres. Interactions with pain continue to be central to explaining various aspects of itch. Certain spinal interneurons (Bhlhb5) inhibit itch pathways within the dorsal horn; they may represent mediators between noxious and pruritic pathways, and allow s...
Source: Brain - February 5, 2014 Category: Neurology Authors: Dhand, A., Aminoff, M. J. Tags: Review Article Source Type: research

Top medicine articles for April 2014
A collection of some interesting medical articles published recently:A Big Bet on Gluten-Free: 11% of households reporting purchases of gluten-free foods in 2013 (doubled in 3 yrs). 30% of the public says it would like to cut back on the amount of gluten it’s eating. "There is a growing population of people who have somehow heard that gluten-free is healthier or think of it as fashionable, and when they remove gluten from their diet, they’re inadvertently taking out a lot of processed foods and are really feeling the benefits of eating healthier foods.” http://buff.ly/1mt9phmNew nomenclature and classifications are p...
Source: Clinical Cases and Images - April 23, 2014 Category: Journals (General) Tags: Health News of the Day Source Type: news

Cutaneous sensory disorder.
Authors: Gupta MA, Gupta AK Abstract Cutaneous sensory disorder (CSD) represents a heterogeneous clinical situation where the patient presents with either disagreeable skin sensations (ie, itching, burning, stinging) or pain (ie, allodynia) and/or negative sensory symptoms (ie, numbness, hypoaesthesia). These patients have no apparent diagnosable dermatologic or medical condition that explains the cutaneous symptom, and typically have negative findings upon medical workup. Skin regions that normally have a greater density of epidermal innervation tend to be more susceptible to the development of CSD. CSDs can affec...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research

Two Tests to Predict How Long You Might Live
In this study of over 6,500 adults (at least 52 years of age), participants were asked that question. Over 8 years of follow-up, people who felt at least 3 years younger than their actual age were less likely to die than those who felt their actual age or older. There are lots of reasons why this might make sense. If you feel older than your age, you probably already have some underlying health conditions. Or you might be depressed which we know leads to increased mortality. If you don't feel "right," you need to listen to your body, and realize it is telling you that you need to get it checked. And the lesson here would b...
Source: Healthy Living - The Huffington Post - July 16, 2015 Category: Consumer Health News Source Type: news

Don’t shrug off shingles
If you had chickenpox as a kid, there is a good chance you may develop shingles later in life. “In fact, one in three is predicted to get shingles during their lifetime,” says Dr. Anne Louise Oaklander, director of the Nerve Unit at Harvard-affiliated Massachusetts General Hospital. The same varicella-zoster virus that causes chickenpox also causes shingles. After the telltale spots of chickenpox vanish, the virus lies dormant in your nerve cells near the spinal cord and brain. When your immunity weakens from normal aging or from illnesses or medications, the virus can re-emerge. It then travels along a nerve to trigge...
Source: New Harvard Health Information - February 18, 2016 Category: Consumer Health News Authors: Matthew Solan Tags: Healthy Aging Infectious diseases Vaccines Source Type: news

How To Find Your Calling (From 5 People Who Found Theirs)
Why does our culture perpetuate the belief that “finding oneself” is an age-specific phase, reserved only for angst-ridden teenagers and wanderlust-stricken 20-somethings? The notion of finding a passion is all-too-frequently aligned with youth and impulsivity, but truthfully, we’re all quietly seeking our next challenge, our next calling. We’re of the belief that it’s never too late to course correct your life, and given the job-hopping numbers, we’re probably not the only ones. Though the U.S. Bureau of Labor Statistics does not regularly track career changes, in a recent study of late...
Source: Healthy Living - The Huffington Post - August 18, 2016 Category: Consumer Health News Source Type: news

Neurologic Itch Management.
Authors: Şavk E Abstract Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range from localized entrapment of a peripheral nerve to generalized degeneration of small nerve fibers. Antipruritic medications commonly used for other types of itch such as antihistamines and corticosteroids lack efficacy in neuropathic itch. Currently there are no therapeutic options that offer relief in all types of neuropathic pruritus, and treatment strategies vary according to etiology. It is...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research

Clinical presentation, management, and pathophysiology of neuropathic itch
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Martin Steinhoff, Martin Schmelz, Imre Lőrinc Szabó, Anne Louise OaklanderSummaryUnlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral nervous system disorders that cause neuropathic pain, such as sensory polyneuropathy, radiculopathy, herpes zoster, stroke, or multiple sclerosis, and lesion location affects symptoms more than aetiology. The causes of neuropathic itch are h...
Source: The Lancet Neurology - July 18, 2018 Category: Neurology Source Type: research