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Condition: Heatstroke

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Total 1318 results found since Jan 2013.

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.
CONCLUSIONS: Heat stroke-induced coagulopathy may be a driving mechanistic force in heat stroke pathology, especially when exacerbated by prior infection. Coagulation markers may serve as accessible biomarkers for heat stroke severity and therapeutic strategies. PMID: 32367690 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 3, 2020 Category: Hematology Authors: Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR Tags: J Thromb Haemost Source Type: research

Heat stroke during treatment with olanzapine, trihexyphenidyl, and trazodone in a patient with schizophrenia.
CONCLUSION: Heat stroke can occur during the maintenance treatment of olanzapine, trihexyphenidyl, and trazodone for schizophrenia. Clinicians should be proactive to reduce the risk of heat stroke in psychiatric patients. PMID: 26503496 [PubMed - in process]
Source: Acta Neuropsychiatrica - October 30, 2015 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Heat stroke
ConclusionThe effectiveness of cooling devices, drugs, and therapies in heat stroke remains inconclusive. Further large studies are required to continue to evaluate these treatment strategies.
Source: Journal of Intensive Care - May 22, 2018 Category: Intensive Care Source Type: research

Heat stroke: knowledge and practices of medical professionals in pediatric emergency medicine departments – a survey study
Conclusions: The present study exposes weaknesses in HCW knowledge, PED resources, and published PED policies for appropriate management of children following heat stroke. Our finding emphasizes the importance of both certificated PEM physicians attendance and simulation performance for implementing proper management of patients with heat stroke. A policy change should be performed among the Israeli PED community, with respect to establishing and implementing guidelines for treatment of exertional heat stroke. A future study, following an interventional simulation program is planned to be performed.
Source: Israel Journal of Health Policy Research - June 2, 2021 Category: International Medicine & Public Health Source Type: research

Lack of lymphocytes exacerbate heat stroke severity in male mice through enhanced inflammatory response
Int Immunopharmacol. 2021 Oct 6;101(Pt A):108206. doi: 10.1016/j.intimp.2021.108206. Online ahead of print.ABSTRACTThough it has long been thought that the immune system is implicated in the pathophysiology of heat stroke, the underlying mechanisms are still poorly understood. As it has been reported in the literature that lymphocyte disturbance occurs in heat stroke patients or animals, we attempted to seek experimental evidence to define the role of lymphocytes in the pathophysiology of heat stroke. In our study, we used male Balb/c mice to establish a passive heat stroke model. We found that lymphocyte-deficient Severe ...
Source: International Immunopharmacology - October 9, 2021 Category: Allergy & Immunology Authors: Yulong Tan Xiaoqian Liu Xueting Yu Tingting Shen Zeze Wang Zhen Luo Xue Luo Xuesen Yang Source Type: research

Lessons From Heat Stroke for Understanding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
We here provide an overview of the pathophysiological mechanisms during heat stroke and describe similar mechanisms found in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Both conditions are characterized by disturbed homeostasis in which inflammatory pathways play a central role. Splanchnic vasoconstriction, increased gut permeability, gut-related endotoxemia, systemic inflammatory response, central nervous system dysfunction, blood coagulation disorder, endothelial-cell injury, and mitochondrial dysfunction underlie heat stroke. These mechanisms have also been documented in ME/CFS. Moreover, initial transc...
Source: Frontiers in Neurology - December 13, 2021 Category: Neurology Source Type: research

On-Site Treatment of Exertional Heat Stroke
Conclusion: On-site treatment of athletes who develop exertional heat stroke appears to be both safe and effective. On-site treatment may decrease the local burden of critically ill patients to emergency departments during large athletic events.
Source: The American Journal of Sports Medicine - March 31, 2015 Category: Sports Medicine Authors: Sloan, B. K., Kraft, E. M., Clark, D., Schmeissing, S. W., Byrne, B. C., Rusyniak, D. E. Tags: Medical aspects of sports, Running General Sports Trauma Source Type: research

Heat Stroke.
This article provides a comprehensive review of recent advances in the identification of risk factors that predispose to heat stroke, the role of endotoxin and cytokines in mediation of multi-organ damage, the incidence of hypothermia and fever during heat stroke recovery, clinical biomarkers of organ damage severity, and protective cooling strategies. Risk factors include environmental factors, medications, drug use, compromised health status, and genetic conditions. The role of endotoxin and cytokines is discussed in the framework of research conducted over 30 years ago that requires reassessment to more clearly identify...
Source: Comprehensive Physiology - April 17, 2015 Category: Physiology Tags: Compr Physiol Source Type: research

Heat Stroke as a Cause of Liver Failure and Evaluation of Liver Transplant.
Abstract Heat stroke is a multiple organ dysfunction syndrome of poorly understood pathogenesis. Exertional heat stroke with acute liver failure is a rarely reported condition. Liver transplant has been recommended as treatment in cases of severe liver dysfunction; however, there are only 5 described cases of long-term survival after this procedure in patients with heat stroke. Here, we present 2 cases of young athletes who developed heat stroke. Both patients developed acute liver failure and were listed for liver transplant. Liver function tests of one patient improved, and he was discharged on postoperative day...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - August 17, 2018 Category: Transplant Surgery Authors: Martins PN, Brüggenwirth IMA, McDaid J, Hertl M, Kawai T, Elias N, Chung RT, Markmann JF Tags: Exp Clin Transplant Source Type: research

“His Entire Body Was Shutting Down”: New State Rankings Show Gaps in High School Athlete Safety
By mid-afternoon on August 1, 2017, the temperature in Stockton, Calif. was at least 105 degrees. Thirteen-year-old Jayden Galbert complained to his mother, Shynelle Jones, about the heat, but didn’t want to skip preseason football practice and hurt his chances of making the freshman football team. Instead, he showed up, pushed himself to participate, and then collapsed on the field. “He started vomiting and he was shaking,” Jones says. “He couldn’t see. He was trying to focus, but he couldn’t.” Jayden was eventually airlifted to UC Davis Medical Center, where he was diagnosed with...
Source: TIME: Health - August 22, 2018 Category: Consumer Health News Authors: Lisa Lewis Tags: Uncategorized health heat stroke high school sports Source Type: news

‘His Entire Body Was Shutting Down.’ New State Rankings Show Gaps in High School Athlete Safety
By mid-afternoon on August 1, 2017, the temperature in Stockton, Calif. was at least 105 degrees. Thirteen-year-old Jayden Galbert complained to his mother, Shynelle Jones, about the heat, but didn’t want to skip preseason football practice and hurt his chances of making the freshman football team. Instead, he showed up, pushed himself to participate, and then collapsed on the field. “He started vomiting and he was shaking,” Jones says. “He couldn’t see. He was trying to focus, but he couldn’t.” Jayden was eventually airlifted to UC Davis Medical Center, where he was diagnosed with...
Source: TIME: Health - August 22, 2018 Category: Consumer Health News Authors: Lisa Lewis Tags: Uncategorized health heat stroke high school sports Source Type: news

Differential Expression Pattern of Exosome Long Non-Coding RNAs (lncRNAs) and MicroRNAs (miRNAs) in Vascular Endothelial Cells Under Heat Stroke.
CONCLUSIONS These results indicate that the identified lncRNAs and miRNAs in endothelial cell exosomes might serve as non-invasive biomarkers for heat stroke. PMID: 30399613 [PubMed - in process]
Source: Medical Science Monitor - November 8, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Analysis of Clinical Symptoms of Guillain –Barré Syndrome Induced by Heat Stroke: Three Case Reports and Literature Review
ConclusionsThe number of the cases of GBS induced by HS reported in this study has been the most in the recent 5 years. Clinicians should pay attention to patients with heat stroke with sustained coma and the sudden quadriplegia. Early, exact and timely diagnosis and treatment of GBS need to be performed, to accelerate recovery and improve prognosis.
Source: Frontiers in Neurology - June 17, 2022 Category: Neurology Source Type: research

The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats.
Abstract Heat stroke is a life-threatening illness characterized by an elevated core body temperature. Despite adequate lowering of the body temperature and support treatment of multiple organ-system function, heat stroke is often fatal. 3-(5'-Hydoxymethyl-2'-furyl)-1-benzyl-indazol (YC-1) been identified as an activator of soluble guanylate cyclase. To evaluate whether YC-1 protects multiple organ dysfunctions and improves survival during heat stroke and its mechanism. Male Sprague-Dawley rats untreated or treated with either YC-1 or quercetin (heat shock protein (Hsp) 70 inhibitor) were exposures to heat as a mo...
Source: European Journal of Pharmacology - December 5, 2012 Category: Drugs & Pharmacology Authors: Lam KK, Cheng PY, Lee YM, Liu YP, Cheng Ding J, Liu WH, Yen MH Tags: Eur J Pharmacol Source Type: research