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Condition: Heart Valve Disease
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Total 330 results found since Jan 2013.

Quality of Care and Outcomes for In-Hospital Ischemic Stroke: Findings From the National Get With The Guidelines-Stroke Clinical Sciences
Conclusions— Compared with community-onset ischemic stroke, patients with in-hospital stroke experienced more severe strokes, received lower adherence to process-based quality measures, and had worse outcomes. These findings suggest there is an important opportunity for targeted quality improvement efforts for patients with in-hospital stroke.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Cumbler, E., Wald, H., Bhatt, D. L., Cox, M., Xian, Y., Reeves, M., Smith, E. E., Schwamm, L., Fonarow, G. C. Tags: Health policy and outcome research, Emergency treatment of Stroke, Risk Factors for Stroke, Thrombolysis Clinical Sciences Source Type: research

Analysis of Risk Factors for In-Hospital Stroke Mortality and Stroke Readmission in Hospital Risoleta Tolentino Neves (HRTN) - Belo Horizonte, Brazil (P1.213)
Conclusions: This study identified previous history of AF, cardiopathy and diabetes as risk-factors for increased stroke in-hospital mortality. We also identified that cardioembolic stroke, previous Chagas' disease and prosthetic heart valve increased the risk of readmission.Disclosure: Dr. Meira has nothing to disclose. Dr. Dorim has nothing to disclose. Dr. Andrade has nothing to disclose. Dr. Santos has nothing to disclose. Dr. Magalhães has nothing to disclose. Dr. Ladeia has nothing to disclose. Dr. Tavares has nothing to disclose. Dr. Xavier has nothing to disclose. Dr. Tanure has nothing to disclose. Dr. Sant...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Meira, F., Dorim, D., Andrade, A. C., Santos, T., Magalhaes, D., Ladeia, L., Tavares, R., Xavier, R., Tanure, M., Santanna, R. Tags: Re-admission and Stroke Outcomes Source Type: research

Knowledge Regarding Oral Anticoagulation Therapy among Patients with Stroke and Those at High Risk of Thromboembolic Events
Apart from atrial fibrillation, indications for oral anticoagulation common in our clinical practice include rheumatic heart disease and mechanical heart valve replacement. Evaluation of current patient knowledge regarding oral anticoagulation therapy (OAT) is the first step in improving the quality of anticoagulation therapy and patient care. The aim of the present study was to assess the knowledge regarding OAT among patients with stroke and those at high risk of thromboembolic events in a tertiary care hospital in India.
Source: Journal of Stroke and Cerebrovascular Diseases - January 7, 2015 Category: Neurology Authors: Annu Alphonsa, Kamlesh K. Sharma, Gautam Sharma, Rohit Bhatia Source Type: research

TAVI: Study finds low stroke rates with Medtronic’s CoreValve
A clinical study of nearly 1,000 patients implanted with Medtronic‘s (NYSE:MDT) CoreValve replacement heart valve found a low rate of stroke out to 2 years. The study, published last month in the Journal of the American College of Cardiology, evaluated patients for neurological events over 3 periods after the procedure to implant the CoreValve transcatheter aortic valve implant: Periprocedural (0 to 1 days); early (2 to 30 days); and late (31 to 730 days). Results from the 996-patient trial, “The Incidence and Predictors of Early- and Mid-Term Clinically Relevant Neurological Events After Transcatheter Aortic ...
Source: Mass Device - August 3, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Clinical Trials Regulatory/Compliance CoreValve Inc. medtronic Source Type: news

Predictors of stroke in patients undergoing cardiac surgery
Conclusion: The study identified the following risk predictors for stroke after cardiac surgery: age, urgent and emergency surgery, aortic valve disease, history of atrial fibrillation, peripheral artery disease, history of cerebrovascular disease and cardiopulmonary bypass time > 110 minutes. OBJETIVOS: Determinar os preditores de risco relacionados ao desenvolvimento de acidente vascular cerebral em pacientes que realizaram cirurgia cardíaca. Métodos: Estudo de coorte histórico. Incluímos 4626 pacientes com idade > 18 anos submetidos à cirurgia de revascularização do miocárdio, cirurgia cardíaca valvar is...
Source: Revista Brasileira de Cirurgia Cardiovascular - August 20, 2014 Category: Cardiovascular & Thoracic Surgery Source Type: research

Propensity Score Matched Analysis of Mechanical vs. Bioprosthetic Valve Replacement in Patients With Previous Stroke.
CONCLUSIONS: In patients with previous stroke, bioprosthetic valves had a lower incidence of complications connected to major bleeding than did the mechanical valves. Survival and stroke recurrence rates, however, did not differ between the 2 groups. We recommend bioprosthetic valves for patients >60 years or who have a history of GI bleeding. PMID: 29794401 [PubMed - as supplied by publisher]
Source: Circulation Journal - May 24, 2018 Category: Cardiology Authors: Chen SW, Wu VC, Lin YS, Chen CC, Chen DY, Chang CH, Chu PH, Ting PC, Chou AH, Chen TH Tags: Circ J Source Type: research

Efficacy of nafamostat mesilate as anticoagulation during cardiopulmonary bypass for early surgery in patients with active infective endocarditis complicated by stroke.
CONCLUSION: Nafamostat mesilate, administered in conjunction with low-dose heparinization, served as an effective anticoagulant for early surgery in patients with AIE complicated by stroke, and caused no further deterioration of the cerebral lesions. PMID: 25790622 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 21, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Abbott Wins Approval for CATALYST Trial for At-Risk Stroke Patients
This study is an extremely important step in assessing the Amplatzer Amulet as an effective non-prescription drug alternative for patients with AFib who are at an increased risk for ischemic stroke." In an email sent to MD+DI, Abbott wrote, “We already have an Amulet IDE trial underway that is intended to support our submission for approval in the U.S. for Amplatzer Amulet. The newly announced CATALYST trial will support our submission for an expanded indication for Amulet as a safe and effective alternative to NOAC drugs for patients with atrial fibrillation and at risk of stroke.” Abbo...
Source: MDDI - February 3, 2020 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Regulatory and Compliance Source Type: news

Stroke prevention in valvular heart disease: from the procedure to long-term management.
Authors: Giustino G, Dangas GD Abstract Stroke in patients with valvular heart disease undergoing transcatheter intervention is relatively rare but associated with significant morbidity and mortality. Risks vary according to the underlying valve disease and proposed procedure. While major improvements have been made in developing and understanding the technical factors associated with intra- and peri-procedural stroke, uncertainty exists regarding the optimal antithrombotic management strategy after transcatheter heart valve intervention and the utility of routine cerebral embolic protection. Further clinical studi...
Source: EuroIntervention - September 20, 2015 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Current and emerging pharmacotherapy for ischemic stroke prevention in patients with atrial fibrillation.
Authors: Székely O, Miyazawa K, Lip GYH Abstract INTRODUCTION: Atrial fibrillation (AF) is associated with high morbidity and mortality rates due to thromboembolic complications, and anticoagulation is central to the management of this common arrhythmia to prevent acute thromboembolic events. The traditional anticoagulants: heparin, fondaparinux, and vitamin K antagonists (VKA, e.g. warfarin, acenocoumarol or phenprocoumin) have long served as pharmacotherapy for ischemic stroke prophylaxis. Areas covered: In this review article, the authors provide an overview on current and emerging pharmacotherapy for ischemic ...
Source: Expert Opinion on Pharmacotherapy - October 27, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Anticoagulation Resumption in a Patient With Mechanical Heart Valves, Antithrombin Deficiency, and Hemorrhagic Transformation Following Thrombectomy After Ischemic Stroke
This study is the first report of administering argatroban and titrating to its appropriate dose in the patient with valve thrombosis, antithrombin deficiency, and HT after mechanical thrombectomy for acute ischemic stroke. Notably, the fluctuations argatroban brings to the coagulation test results might not be interpreted as increased bleeding risk. This case also suggested that the reported timing (day 6 to day 14 after hemorrhage) of anticoagulant resumption in primary intracerebral hemorrhage with mechanical valves might be late for some patients with HT.
Source: Frontiers in Pharmacology - December 16, 2020 Category: Drugs & Pharmacology Source Type: research

Stroke is not a treatment dilemma for early valve surgery in active infective endocarditis.
CONCLUSION: Surgery for AIE with cerebral septic embolisms can be performed safely, with good early and mid-term follow-up results. When urgent or emergent surgery for AIE is needed, neurologic complications should not be a reason for delay. PMID: 25799711 [PubMed - in process]
Source: Journal of Heart Valve Disease - March 25, 2015 Category: Cardiology Tags: J Heart Valve Dis Source Type: research

Knowledge Regarding Oral Anticoagulation Therapy among Patients with Stroke and Those at High Risk of Thromboembolic Events (P6.241)
Conclusion- Patient’s knowledge about OAT was suboptimal. The findings support the need for educational interventions to improve the knowledge regarding oral anticoagulation therapy, and thereby achieve an appropriate and safe secondary prevention of stroke.Disclosure: Dr. Bhatia has nothing to disclose. Dr. Alphonsa has nothing to disclose. Dr. Sharma has nothing to disclose. Dr. Sharma has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Bhatia, R., Alphonsa, A., Sharma, K., Sharma, G. Tags: Cerebrovascular Disease and Interventional Neurology: Thrombolysis Complications Source Type: research

Low mortality, stroke seen with newest Edwards TAVR system: study
(Reuters) - Researchers on Sunday presented trial data showing very low mortality and stroke rates using the third generation version of Edwards Lifesciences Corp's non-invasive heart valve replacement system that could help support its U.S. approval.
Source: Reuters: Health - March 15, 2015 Category: Consumer Health News Tags: healthNews Source Type: news

Automatic extraction of forward stroke volume using dynamic PET/CT: a dual-tracer and dual-scanner validation in patients with heart valve disease
Background: The aim of this study was to develop and validate an automated method for extracting forward stroke volume (FSV) using indicator dilution theory directly from dynamic positron emission tomography (PET) studies for two different tracers and scanners. Methods: 35 subjects underwent a dynamic 11 C-acetate PET scan on a Siemens Biograph TruePoint-64 PET/CT (scanner I). In addition, 10 subjects underwent both dynamic 15 O-water PET and 11 C-acetate PET scans on a GE Discovery-ST PET/CT (scanner II). The left ventricular (LV)-aortic time-activity curve...
Source: Epidemiologic Perspectives and Innovations - October 26, 2015 Category: Epidemiology Authors: Hendrik HarmsLars TolbodNils HanssonTanja KeroLovisa OrndahlWon KimTomas BjernerKirsten BoucheloucheHenrik WiggersJørgen FrøkiærJens Sörensen Source Type: research