Abbott Wins Approval for CATALYST Trial for At-Risk Stroke Patients
This study is an extremely important step in assessing the Amplatzer Amulet as an effective non-prescription drug alternative for patients with AFib who are at an increased risk for ischemic stroke." In an email sent to MD+DI, Abbott wrote, âWe already have an Amulet IDE trial underway that is intended to support our submission for approval in the U.S. for Amplatzer Amulet. The newly announced CATALYST trial will support our submission for an expanded indication for Amulet as a safe and effective alternative to NOAC drugs for patients with atrial fibrillation and at risk of stroke.â Abbott added, âIn the U.S. alone, AFib prevalence is projected to increase from 5.2 million in 2010 to 12.1 million cases in 2030. With our Amplatzer Amulet device, we hope to provide physicians with an alternative option for their patients with AFib and potentially eliminate the need for blood thinners long-term.â Abbott inherited the Amplatzer through the $25 billion acquisition of St. Jude Medical. The Amplatzer Amulet device received CE Mark approval in 2013. The Amplatzer Amulet (LAA) occlusion device has been shown at one year to reduce stroke by 57% as compared to the predicted stroke risk. The data also showed it was able to make this reduction without the need for lifetime blood thinners. Abbott released this data at EuroPCR, the annual meeting of the European Association of Percutaneous Cardiovascular Interventi...
Publication date: Available online 28 March 2020Source: Materials Today: ProceedingsAuthor(s): S. Godwin Barnabas, S. Valai Ganesh, V. Sivakumar, P. Muthukumar, A. Dhinesh Raja, K. Hariharan
Publication date: Available online 29 March 2020Source: CytotherapyAuthor(s): Helena Debiazi Zomer, Talita da Silva Jeremias, Buddy Ratner, Andrea Goncalves Trentin
Publication date: Available online 28 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Naoki Akazawa, Yasushi Takagi, Shinji Nagahiro
Authors: Miura M, Fujinami N, Shimizu Y, Mizuno S, Saito K, Suzuki T, Konishi M, Takahashi S, Gotohda N, Suto K, Yoshida T, Nakatsura T Abstract Predicting the risk of hepatocellular carcinoma (HCC) recurrence before treatment is necessary for developing subsequent treatment policies. Several tumor markers found in blood, such as alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II), are presently used to determine the occurrence and recurrence of HCC and to predict patient prognosis. However, these markers are insufficient for these purposes as certain patients have HCC recur...
Authors: Ma Y, Chen P, Drisko JA, Khabele D, Godwin AK, Chen Q Abstract The promise of poly(ADP-ribose) polymerase inhibitors (PARPis) in the management of epithelial ovarian cancer (EOC) is hampered by the limited clinical activity against BRCA wild-type or homologous recombination-proficient EOC. In order to decrease the resistance and increase the efficacy of PARPis, combination treatments of pharmacological ascorbate and PARPis in preclinical BRCA wild-type EOC models were investigated. The cytotoxicity of pharmacological ascorbate, olaparib and veliparib in a panel of BRCA1/2 wild-type EOC cell lines were meas...
Publication date: Available online 28 March 2020Source: The Annals of Thoracic SurgeryAuthor(s): Stevan S. Pupovac, Jonathan M. Hemli, Karthik Seetharam, Ashley T. Giammarino, S Jacob Scheinerman, Alan R. Hartman, Derek R. Brinster
Publication date: Available online 26 March 2020Source: The Annals of Thoracic SurgeryAuthor(s): Murat Kadan, Kubilay Karabacak, Cengiz Bolcal
Publication date: Available online 29 March 2020Source: Food HydrocolloidsAuthor(s): Hualu Zhou, Yunbing Tan, Shanshan Lv, Jinning Liu, Jorge L. Muriel Mundo, Long Bai, Orlando J. Rojas, David Julian McClements
Authors: Kim SY, Jeon SW, Lim WJ, Oh KS, Shin DW, Cho SJ, Park JH, Shin YC Abstract OBJECTIVE: The aim of study is to investigate the relationship between serum vitamin D, c-reactive protein (CRP) levels, and anxiety symptoms. METHODS: Serum vitamin D and CRP levels of 51,003 Korean adult participants were collected retrospectively. Anxiety symptoms were assessed using the Korean version of Beck Anxiety Inventory. Logistic regression was used to estimate the odds ratio (ORs) of anxiety symptoms by serum vitamin D and CRP levels. The regression was adjusted for covariates, and each model was adjusted mutually fo...
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